Binge drinking in adolescence may increase risk for anxiety later in life
March 11, 2019
Science Daily/University of Illinois at Chicago
Researchers have found that adolescent binge drinking, even if discontinued, increases the risk for anxiety later in life due to abnormal epigenetic programming.
A growing body of evidence supports the idea that alcohol exposure early in life has lasting effects on the brain and increases the risk of psychological problems in adulthood. Now, researchers at the University of Illinois at Chicago have found that adolescent binge drinking, even if discontinued, increases the risk for anxiety later in life due to abnormal epigenetic programming. The findings of the study, which was conducted in animals, was published in the journal Biological Psychiatry.
"Binge drinking early in life modifies the brain and changes connectivity in the brain, especially in the amygdala, which is involved in emotional regulation and anxiety, in ways we don't totally understand yet," said Subhash Pandey, professor of psychiatry in the UIC College of Medicine, director of the UIC Center for Alcohol Research in Epigenetics and lead author of the study. "But what we do know is that epigenetic changes are lasting, and increase susceptibility to psychological issues later in life, even if drinking that took place early in life is stopped."
"Epigenetics" refers to chemical changes to DNA, RNA, or specific proteins associated with chromosomes that change the activity of genes without changing the genes themselves. Epigenetic alterations are required for the normal development of the brain, but they can be modified in response to environmental or even social factors, such as alcohol and stress. These kinds of epigenetic alterations have been linked to changes in behavior and disease.
Adolescent rats were exposed to ethanol (a type of alcohol) for two days on and two days off or to the same protocol using saline for 14 days. All rats underwent an assessment for anxiety.
Pandey and his colleagues exposed adolescent rats to a regimen designed to mimic binge drinking. Those rats exhibited anxious behavior later in life, even if the binge drinking regimen stopped in late adolescence and the rats were allowed to mature to adulthood without any further exposure to alcohol.
These rats also had lower levels of a protein called Arc in the amygdala. Arc is important for the normal development of synaptic connections in the brain. Rats with less Arc also had about 40 percent fewer neuronal connections in the amygdala compared with rats that weren't exposed to alcohol.
"We believe that the decrease in Arc levels is caused by epigenetic changes that alter the expression of Arc, and an enhancer RNA, which modifies the expression of Arc. These changes are caused by adolescent alcohol exposure," said Pandey.
"Exposure to alcohol causes epigenetic reprogramming to occur, leading to molecular changes in the amygdala, which are long-lasting, even in the absence of more alcohol," said Pandey, who is also a senior research career scientist at the Jesse Brown VA Medical Center. "If the amygdala has deficits in its wiring or connectivity, and these modifications are long-lasting, the individual is at risk for psychological issues based on difficulties in regulating emotions, such as anxiety or depression and the development of alcohol use disorder later in life."
https://www.sciencedaily.com/releases/2019/03/190311125156.htm
Dealing with Stress as a Treatment for Alcohol Abuse
October 28, 2007
Science Daily/University at Buffalo
An addictions researcher is initiating a study of "mindfulness-based stress reduction," a technique often used in behavioral medicine for stress reduction but not before as an adjunct in the treatment of alcohol use disorders.
A researcher at the University at Buffalo's Research Institute on Addictions (RIA) is initiating a study of "mindfulness-based stress reduction," a technique often used in behavioral medicine for stress reduction but not before as an adjunct in the treatment of alcohol use disorders.
"By adapting and applying mindfulness-based stress reduction or MBSR in alcoholism treatment, we hope to develop an increased ability to cope with stress and enhanced psychological well-being among alcohol-dependent individuals," said Gerard J. Connors, Ph.D. "For people who often deal with stress in their lives by turning to alcohol, this could be a very positive alternative."
Connors is a clinical psychologist and principal investigator on the study as well as the director of RIA. He also is a professor in the Department of Psychology in the UB College of Arts and Sciences and research professor in the Department of Psychiatry in the UB School of Medicine and Biomedical Sciences.
The four-year investigation on MBSR will be conducted with support from a $1.9 million grant from the National Institute on Alcohol Abuse and Alcoholism.
The MBSR intervention provides intensive training in mindfulness practices and their applications for daily living and coping with stress. MBSR emphasizes self-observation and self-responsibility, which is expected to facilitate the alcohol-dependent individual's management of the stressors that place the person at increased risk for drinking.
The project will be conducted in two phases, with the first component to include development of an eight-session treatment manual for conducting group-based MBSR with alcohol-dependent men and women. In phase two, a pilot clinical trial will be conducted to examine the effects of adding MBSR to outpatient treatment.
The long-term goal is to decrease relapse to drinking following treatment, thereby providing significant health benefits to people being treated for alcohol dependence, with corresponding benefits for their families and the community-at-large.
http://www.sciencedaily.com/releases/2007/10/071026162329.htm
Stress drives alcoholics' children to drink
September 24, 2011
Science Daily/University of Gothenburg
If either of your parents has a drink problem, there is a greater risk that you will consume more alcohol after stressful situations, new research from Sweden suggests.
It has long been known that alcoholics' children are 50% more likely to have a drink problem in the future, and new research from the Sahlgrenska Academy is shedding new light on this link. Carried out by researcher Anna Söderpalm Gordh, the study has been published in the most recent issue of the journal Pharmacology Biochemistry and Behaviour.
"The results show that people with parents who have a history of alcohol abuse drink more than others when exposed to stress," says Söderpalm Gordh.
This behaviour can have negative consequences in the long term. It is no secret that people who consume large quantities of alcohol every time they drink run a higher risk of developing a dependency in the future.
"If alcohol relaxes you when you're stressed, then you should try to find other ways of calming yourself down -- relaxation exercises, for example," says Söderpalm Gordh.
About Alcoholism
Alcoholism is usually divided into two categories: type I and type II. Type I is largely dependent on our genes' interaction with the environment, for example the people we socialise with or the crises in our lives, while type II involves a considerable genetic risk of developing a drink problem, irrespective of our environment.
http://www.sciencedaily.com/releases/2011/09/110920075518.htm
Drinking makes you older at the cellular level
June 26, 2017
Science Daily/Research Society on Alcoholism
The more alcohol that people drink, the more their cells appear to age. Researchers found that alcoholic patients had shortened telomere lengths, placing them at greater risk for age-related illnesses, such as cardiovascular disease, diabetes, cancer and dementia..
"Telomeres, the protein caps on the ends of human chromosomes, are markers of aging and overall health," said Naruhisa Yamaki, M.D., a clinical fellow at the Kobe University Graduate School of Medicine. Yamaki explained that every time a cell replicates, a tiny bit of telomere is lost, so they get shorter with age. But some groups may have shorter telomeres for reasons other than aging.
"Our study showed that alcoholic patients have a shortened telomere length, which means that heavy drinking causes biological aging at a cellular level," he said. "It is alcohol rather than acetaldehyde that is associated with a shortened telomere length." Yamaki will present this research at the RSA meeting on June 25.
Yamaki and his co-authors recruited 255 study participants from alcoholism treatment services at Kurihama National Hospital in Yokosuka, Japan: 134 alcoholic patients and 121 age-matched controls or non-alcoholics, ranging in age from 41 to 85 years old. DNA samples, as well as drinking histories and habits, were collected from all participants.
"We also found an association between telomere shortening and thiamine deficiency (TD)," said Yamaki. "TD is known to cause neuron impairments such as Wernicke-Korsakoff Syndrome. Although how exactly TD can cause neural impairments is unclear, it is well known that oxidation stress cause telomere shortening and, thus, it is possible that oxidation stress may also cause neuron death."
Yamaki added that it's important for the public to understand that heavy drinking causes telomere shortening because "awareness of this fact provides important information necessary for people to live healthier."
https://www.sciencedaily.com/releases/2017/06/170626105322.htm