Fathers-to-be should avoid alcohol six months before conception
Parental alcohol consumption linked to raised risk of congenital heart disease
October 3, 2019
Science Daily/European Society of Cardiology
Aspiring parents should both avoid drinking alcohol prior to conception to protect against congenital heart defects, according to research published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).
Drinking alcohol three months before pregnancy or during the first trimester was associated with a 44% raised risk of congenital heart disease for fathers and 16% for mothers, compared to not drinking. Binge drinking, defined as five or more drinks per sitting, was related to a 52% higher likelihood of these birth defects for men and 16% for women.
'Binge drinking by would-be parents is a high risk and dangerous behaviour that not only may increase the chance of their baby being born with a heart defect, but also greatly damages their own health,' said study author Dr Jiabi Qin, of Xiangya School of Public Health, Central South University, Changsha, China.
Dr Qin said the results suggest that when couples are trying for a baby, men should not consume alcohol for at least six months before fertilisation while women should stop alcohol one year before and avoid it while pregnant.
Congenital heart diseases are the most common birth defects, with approximately 1.35 million babies affected every year. These conditions can increase the likelihood of cardiovascular disease later life, even after surgical treatment, and are the main cause of perinatal death. Alcohol is a known teratogen and has been connected with fetal alcohol spectrum disorder (FASD). Around one in four children with FASD have congenital heart disease, indicating that alcohol might also be implicated in these disorders.
Previous studies investigating the link between alcohol and congenital heart disease have focused on prospective mothers, with inconclusive results. This is the first meta-analysis to examine the role of paternal alcohol drinking.
The researchers compiled the best data published between 1991 and 2019, which amounted to 55 studies including 41,747 babies with congenital heart disease and 297,587 without. The analysis showed a nonlinear dose-response relationship between parental alcohol drinking and congenital heart diseases.
Dr Qin said: 'We observed a gradually rising risk of congenital heart diseases as parental alcohol consumption increased. The relationship was not statistically significant at the lower quantities.'
Regarding specific defects, the study found that compared to abstinence, maternal drinking was correlated to a 20% greater risk of tetralogy of Fallot, a combination of four abnormalities in the heart's structure.
The authors noted that this was an observational study and does not prove a causal effect, nor does it prove that paternal drinking is more harmful to the fetal heart than maternal drinking. The data cannot be used to define a cut-off of alcohol consumption that might be considered safe.
Dr Qin said: 'The underlying mechanisms connecting parental alcohol and congenital heart diseases are uncertain and warrant further research. Although our analysis has limitations -- for example the type of alcohol was not recorded -- it does indicate that men and women planning a family should give up alcohol.'
https://www.sciencedaily.com/releases/2019/10/191003074846.htm
One in 10 older American adults currently binge drinks
Men, cannabis users more likely to engage in this risky behavior
July 31, 2019
Science Daily/New York University
More than a tenth of U.S. adults age 65 and older currently binge drink, putting them at risk for a range of health problems, according to a study by researchers at NYU School of Medicine and the Center for Drug Use and HIV/HCV Research (CDUHR) at NYU College of Global Public Health.
The study, published in the Journal of the American Geriatrics Society, also finds certain factors -- including using cannabis and being male -- are associated with an increase in binge drinking.
Binge drinking is a risky behavior, particularly for older adults due to aging-related physical changes (for instance, an increased risk of falling) and the likelihood of having chronic health issues. Despite the potential for harm, little research has focused on binge drinking among older adults.
"Binge drinking, even episodically or infrequently, may negatively affect other health conditions by exacerbating disease, interacting with prescribed medications, and complicating disease management," said Benjamin Han, MD, MPH, the study's lead author and an assistant professor in the Department of Medicine's Division of Geriatric Medicine and Palliative Care, and the Department of Population Health at NYU Langone Health.
In this study, Han and his colleagues used the most recent national data to determine the current prevalence and factors that may increase the risk of binge drinking among adults. The researchers examined data from 10,927 U.S. adults age 65 and older who participated in the National Survey on Drug Use and Health between 2015 and 2017. They looked at the prevalence of current (past-month) binge alcohol use, defined by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) as five drinks or more on the same occasion for men and four drinks or more for women. They also compared demographic and health factors of past-month binge drinkers with people who drank within the past month, but below the binge drinking threshold.
The authors estimate that more than one in 10 (10.6 percent) older adults have binge drank in the past month -- an increase compared to earlier studies. In the decade leading up to the data used in this study (2005-2014), binge drinking among adults 65 and older was between 7.7 and 9 percent.
Binge drinkers were more likely to be male, current tobacco and/or cannabis users, African American, and have less than a high school education. They were also more likely to visit the emergency room in the past year. Similar to previous studies, the study did not find associations between binge drinking and other mental health disorders.
"The association of binge drinking with cannabis use has important health implications. Using both may lead to higher impairment effects. This is particularly important as cannabis use is becoming more prevalent among older adults, and older adults may not be aware of the possible dangers of using cannabis with alcohol," said CDUHR researcher Joseph Palamar, PhD, MPH, the study's senior author and an associate professor in the Department of Population Health at NYU Langone Health.
The researchers also examined chronic disease profiles of older binge drinkers, and noted that binge drinkers had a lower prevalence of two or more chronic diseases compared to non-binge drinkers. The most common chronic disease among binge drinkers was hypertension (41.4 percent), followed by cardiovascular disease (23.1 percent) and diabetes (17.7 percent).
"Binge drinkers were less likely to have most chronic diseases compared to alcohol users who did not binge drink. This may be because some people stop or decrease their drinking when they have an illness or alcohol-related disease," said Han, who is also a CDUHR researcher. "Clinicians must be aware that some older adults with chronic disease still engage in binge drinking behaviors, which can worsen their health issues. This may explain why binge drinkers were more likely to report visits to the emergency room."
The researchers note that while the study uses the NIAAA's recommended threshold for binge drinking, the same organization also suggests lower drinking limits for adults over 65: no more than three drinks a day. Since the current analysis used the higher cutoff for binge drinking, the study may underestimate the prevalence of binge drinking among older adults.
"Our results underscore the importance of educating, screening, and intervening to prevent alcohol-related harms in older adults, who may not be aware of their heightened risk for injuries and how alcohol can exacerbate chronic diseases," said Han.
https://www.sciencedaily.com/releases/2019/07/190731102212.htm
Binge drinking in adolescence may increase risk for anxiety later in life
March 11, 2019
Science Daily/University of Illinois at Chicago
Researchers have found that adolescent binge drinking, even if discontinued, increases the risk for anxiety later in life due to abnormal epigenetic programming.
A growing body of evidence supports the idea that alcohol exposure early in life has lasting effects on the brain and increases the risk of psychological problems in adulthood. Now, researchers at the University of Illinois at Chicago have found that adolescent binge drinking, even if discontinued, increases the risk for anxiety later in life due to abnormal epigenetic programming. The findings of the study, which was conducted in animals, was published in the journal Biological Psychiatry.
"Binge drinking early in life modifies the brain and changes connectivity in the brain, especially in the amygdala, which is involved in emotional regulation and anxiety, in ways we don't totally understand yet," said Subhash Pandey, professor of psychiatry in the UIC College of Medicine, director of the UIC Center for Alcohol Research in Epigenetics and lead author of the study. "But what we do know is that epigenetic changes are lasting, and increase susceptibility to psychological issues later in life, even if drinking that took place early in life is stopped."
"Epigenetics" refers to chemical changes to DNA, RNA, or specific proteins associated with chromosomes that change the activity of genes without changing the genes themselves. Epigenetic alterations are required for the normal development of the brain, but they can be modified in response to environmental or even social factors, such as alcohol and stress. These kinds of epigenetic alterations have been linked to changes in behavior and disease.
Adolescent rats were exposed to ethanol (a type of alcohol) for two days on and two days off or to the same protocol using saline for 14 days. All rats underwent an assessment for anxiety.
Pandey and his colleagues exposed adolescent rats to a regimen designed to mimic binge drinking. Those rats exhibited anxious behavior later in life, even if the binge drinking regimen stopped in late adolescence and the rats were allowed to mature to adulthood without any further exposure to alcohol.
These rats also had lower levels of a protein called Arc in the amygdala. Arc is important for the normal development of synaptic connections in the brain. Rats with less Arc also had about 40 percent fewer neuronal connections in the amygdala compared with rats that weren't exposed to alcohol.
"We believe that the decrease in Arc levels is caused by epigenetic changes that alter the expression of Arc, and an enhancer RNA, which modifies the expression of Arc. These changes are caused by adolescent alcohol exposure," said Pandey.
"Exposure to alcohol causes epigenetic reprogramming to occur, leading to molecular changes in the amygdala, which are long-lasting, even in the absence of more alcohol," said Pandey, who is also a senior research career scientist at the Jesse Brown VA Medical Center. "If the amygdala has deficits in its wiring or connectivity, and these modifications are long-lasting, the individual is at risk for psychological issues based on difficulties in regulating emotions, such as anxiety or depression and the development of alcohol use disorder later in life."
https://www.sciencedaily.com/releases/2019/03/190311125156.htm
More young people are choosing not to drink alcohol
October 9, 2018
Science Daily/BioMed Central
Young people in England aren't just drinking less alcohol -- a new study shows that more of them are never taking up alcohol at all, and that the increase is widespread among young people.
Researchers at University College London analysed data from the annual Health Survey for England and found that the proportion of 16-24 year olds who don't drink alcohol has increased from 18% in 2005 to 29% in 2015.
The authors found this trend to be largely due to an increasing number of people who had never been drinkers, from 9% in 2005 to 17% in 2015. There were also significant decreases in the number of young people who drank above recommended limits (from 43% to 28%) or who binge drank (27% to 18%). More young people were also engaging in weekly abstinence (from 35% to 50%)
Dr Linda Ng Fat, corresponding author of the study said: "Increases in non-drinking among young people were found across a broad range of groups, including those living in northern or southern regions of England, among the white population, those in full-time education, in employment and across all social classes and healthier groups. That the increase in non-drinking was found across many different groups suggests that non-drinking may becoming more mainstream among young people which could be caused by cultural factors."
Dr Ng Fat said: "These trends are to be welcomed from a public-health standpoint. Factors influencing the shift away from drinking should be capitalised on going forward to ensure that healthier drinking behaviours in young people continue to be encouraged."
Dr Linda Ng Fat added: "The increase in young people who choose not to drink alcohol suggests that this behaviour maybe becoming more acceptable, whereas risky behaviours such as binge drinking may be becoming less normalised."
Increases in non-drinking however were not found among ethnic minorities, those with poor mental health and smokers suggesting that the risky behaviours of smoking and alcohol continue to cluster.
The researchers examined data on 9,699 people aged 16-24 years collected as part of the Health Survey for England 2005-2015, an annual, cross-sectional, nationally representative survey looking at changes in the health and lifestyles of people across England. The authors analysed the proportion of non-drinkers among social demographic and health sub-groups, along with alcohol units consumed by those that did drink and levels of binge drinking.
The authors caution that the cross-sectional, observational nature of this study does not allow for conclusions about cause and effect.
https://www.sciencedaily.com/releases/2018/10/181009210727.htm
Adolescents with a sunny outlook on life may have better health in their adult years
July 23, 2011
Science Daily/Northwestern University
Teenagers are known for their angst-ridden ways, but those who remain happy and positive during the tumultuous teenage years report better general health when they are adults, according to a new Northwestern University study.
Researchers also found that teens with high positive well-being had a reduced risk of engaging in unhealthy behaviors such as smoking, binge drinking, using drugs and eating unhealthy foods as they transitioned into young adulthood.
The study, one of the first to focus on the effect positive psychological characteristics in adolescence can have on long-term health, is published in the July 2011 issue of the Journal of Adolescent Health.
http://www.sciencedaily.com/releases/2011/07/110719072806.htm