Fathers-to-be should avoid alcohol six months before conception
Parental alcohol consumption linked to raised risk of congenital heart disease
October 3, 2019
Science Daily/European Society of Cardiology
Aspiring parents should both avoid drinking alcohol prior to conception to protect against congenital heart defects, according to research published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).
Drinking alcohol three months before pregnancy or during the first trimester was associated with a 44% raised risk of congenital heart disease for fathers and 16% for mothers, compared to not drinking. Binge drinking, defined as five or more drinks per sitting, was related to a 52% higher likelihood of these birth defects for men and 16% for women.
'Binge drinking by would-be parents is a high risk and dangerous behaviour that not only may increase the chance of their baby being born with a heart defect, but also greatly damages their own health,' said study author Dr Jiabi Qin, of Xiangya School of Public Health, Central South University, Changsha, China.
Dr Qin said the results suggest that when couples are trying for a baby, men should not consume alcohol for at least six months before fertilisation while women should stop alcohol one year before and avoid it while pregnant.
Congenital heart diseases are the most common birth defects, with approximately 1.35 million babies affected every year. These conditions can increase the likelihood of cardiovascular disease later life, even after surgical treatment, and are the main cause of perinatal death. Alcohol is a known teratogen and has been connected with fetal alcohol spectrum disorder (FASD). Around one in four children with FASD have congenital heart disease, indicating that alcohol might also be implicated in these disorders.
Previous studies investigating the link between alcohol and congenital heart disease have focused on prospective mothers, with inconclusive results. This is the first meta-analysis to examine the role of paternal alcohol drinking.
The researchers compiled the best data published between 1991 and 2019, which amounted to 55 studies including 41,747 babies with congenital heart disease and 297,587 without. The analysis showed a nonlinear dose-response relationship between parental alcohol drinking and congenital heart diseases.
Dr Qin said: 'We observed a gradually rising risk of congenital heart diseases as parental alcohol consumption increased. The relationship was not statistically significant at the lower quantities.'
Regarding specific defects, the study found that compared to abstinence, maternal drinking was correlated to a 20% greater risk of tetralogy of Fallot, a combination of four abnormalities in the heart's structure.
The authors noted that this was an observational study and does not prove a causal effect, nor does it prove that paternal drinking is more harmful to the fetal heart than maternal drinking. The data cannot be used to define a cut-off of alcohol consumption that might be considered safe.
Dr Qin said: 'The underlying mechanisms connecting parental alcohol and congenital heart diseases are uncertain and warrant further research. Although our analysis has limitations -- for example the type of alcohol was not recorded -- it does indicate that men and women planning a family should give up alcohol.'
https://www.sciencedaily.com/releases/2019/10/191003074846.htm
One in 10 older American adults currently binge drinks
Men, cannabis users more likely to engage in this risky behavior
July 31, 2019
Science Daily/New York University
More than a tenth of U.S. adults age 65 and older currently binge drink, putting them at risk for a range of health problems, according to a study by researchers at NYU School of Medicine and the Center for Drug Use and HIV/HCV Research (CDUHR) at NYU College of Global Public Health.
The study, published in the Journal of the American Geriatrics Society, also finds certain factors -- including using cannabis and being male -- are associated with an increase in binge drinking.
Binge drinking is a risky behavior, particularly for older adults due to aging-related physical changes (for instance, an increased risk of falling) and the likelihood of having chronic health issues. Despite the potential for harm, little research has focused on binge drinking among older adults.
"Binge drinking, even episodically or infrequently, may negatively affect other health conditions by exacerbating disease, interacting with prescribed medications, and complicating disease management," said Benjamin Han, MD, MPH, the study's lead author and an assistant professor in the Department of Medicine's Division of Geriatric Medicine and Palliative Care, and the Department of Population Health at NYU Langone Health.
In this study, Han and his colleagues used the most recent national data to determine the current prevalence and factors that may increase the risk of binge drinking among adults. The researchers examined data from 10,927 U.S. adults age 65 and older who participated in the National Survey on Drug Use and Health between 2015 and 2017. They looked at the prevalence of current (past-month) binge alcohol use, defined by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) as five drinks or more on the same occasion for men and four drinks or more for women. They also compared demographic and health factors of past-month binge drinkers with people who drank within the past month, but below the binge drinking threshold.
The authors estimate that more than one in 10 (10.6 percent) older adults have binge drank in the past month -- an increase compared to earlier studies. In the decade leading up to the data used in this study (2005-2014), binge drinking among adults 65 and older was between 7.7 and 9 percent.
Binge drinkers were more likely to be male, current tobacco and/or cannabis users, African American, and have less than a high school education. They were also more likely to visit the emergency room in the past year. Similar to previous studies, the study did not find associations between binge drinking and other mental health disorders.
"The association of binge drinking with cannabis use has important health implications. Using both may lead to higher impairment effects. This is particularly important as cannabis use is becoming more prevalent among older adults, and older adults may not be aware of the possible dangers of using cannabis with alcohol," said CDUHR researcher Joseph Palamar, PhD, MPH, the study's senior author and an associate professor in the Department of Population Health at NYU Langone Health.
The researchers also examined chronic disease profiles of older binge drinkers, and noted that binge drinkers had a lower prevalence of two or more chronic diseases compared to non-binge drinkers. The most common chronic disease among binge drinkers was hypertension (41.4 percent), followed by cardiovascular disease (23.1 percent) and diabetes (17.7 percent).
"Binge drinkers were less likely to have most chronic diseases compared to alcohol users who did not binge drink. This may be because some people stop or decrease their drinking when they have an illness or alcohol-related disease," said Han, who is also a CDUHR researcher. "Clinicians must be aware that some older adults with chronic disease still engage in binge drinking behaviors, which can worsen their health issues. This may explain why binge drinkers were more likely to report visits to the emergency room."
The researchers note that while the study uses the NIAAA's recommended threshold for binge drinking, the same organization also suggests lower drinking limits for adults over 65: no more than three drinks a day. Since the current analysis used the higher cutoff for binge drinking, the study may underestimate the prevalence of binge drinking among older adults.
"Our results underscore the importance of educating, screening, and intervening to prevent alcohol-related harms in older adults, who may not be aware of their heightened risk for injuries and how alcohol can exacerbate chronic diseases," said Han.
https://www.sciencedaily.com/releases/2019/07/190731102212.htm