The new 'runner's high'? Some often mix weed, workouts

82% of cannabis users say they partake before, after exercise

May 1, 2019

Science Daily/University of Colorado at Boulder

Eight out of 10 marijuana users in states where cannabis is legal say they partake in the drug shortly before or after exercise, and most report that it motivates them to work out, helps them enjoy exercise more and improves their recovery, according to surprising new University of Colorado Boulder research.

The paper, published Tuesday in the journal Frontiers in Public Health, is among the first to explore the complicated intersection between cannabis use and physical activity.

While many assume the former impedes the later, the data suggest otherwise.

"There is a stereotype that cannabis use leads people to be lazy and couch-locked and not physically active, but these data suggest that this is not the case," said senior author Angela Bryan, a professor in the Department of Psychology and Neuroscience and the Institute for Cognitive Science.

She stresses that she is in no way recommending using cannabis as an adjunct to exercise.

"The evidence is not there yet," she said. "But I am also not convinced it is harmful."

Marijuana is now legal for recreational use in 10 states and medicinal use in dozens more. Yet, little is known about how rising acceptance could impact public health measures like physical activity and obesity.

Some have speculated that increased use could worsen the obesity epidemic by fueling a sedentary lifestyle. On the other hand, the authors note, the World Anti-Doping Agency prohibits cannabis use in sporting competitions due to its potential to improve performance.

Anecdotally, ultrarunners sometimes use marijuana to battle nausea and boredom on long runs. And epidemiological studies show cannabis-users tend to be leaner, less prone to diabetes and have healthier blood sugar levels.

"There are a lot of interesting data points and hypotheses out there but not a lot of them have been tested," says Bryan.

In a first step toward filling the research gap, she and her colleagues surveyed 600 adult marijuana users in California, Colorado, Nevada, Oregon and Washington, asking -- among other questions -- if they ever used cannabis within one hour before or four hours after exercise.

Eighty-two percent said 'yes.'

"We were stunned it was that high," says Bryan.

A follow-up question of 345 "co-users" (people who use cannabis with exercise) found they were more likely to use it after than before. But 67% said they did both.

Among those who co-used, 70% said it increased enjoyment of exercise, 78% said it boosted recovery, and 52% said it heightened motivation.

"Given that these are all recognized barriers to exercise, it is possible that cannabis might actually serve as a benefit to exercise engagement," the authors write.

Only 38% said it boosted performance, and in fact some small previous studies have suggested it may harm it.

Notably, those who co-used also got about 43 minutes more exercise per week than those who didn't.

How might cannabis, physiologically, impact physical activity?

"There is evidence to suggest that certain cannabinoids dampen pain perception, and we also know that the receptors cannabis binds to in the brain are very similar to the receptors that are activated naturally during the runners high," said co-author Arielle Gillman, a former PhD student in Bryan's lab who recently published a review paper on the subject. "Theoretically, you could imagine that if it could dampen pain and induce an artificial 'runner's high,' it could keep people motivated."

Cannabis is also anti-inflammatory, which could aid recovery.

The study did not look at which kind of cannabis (edibles, smoked flower, etc.) people use alongside exercise.

The authors note that the survey has limitations, in that it looked only at people who use cannabis regularly and focused on states which have already legalized it.

But more research is already in the works at CU Boulder, comparing the activity levels of older adults who use cannabis with those who do not.

Preliminary results of that separate study show that after embarking on a 16-week exercise program, the cannabis users exercised more than the non-users.

"As we get older, exercise starts to hurt, and that is one reason older adults don't exercise as much," Bryan said. "If cannabis could ease pain and inflammation, helping older adults to be more active that could be another benefit."

Graduate students Sophie York Williams (first author), Charleen Gust and Raeghan Mueller, Assistant Professor Cinnamon Bidwell and Professor Kent Hutchison contributed to this study.

https://www.sciencedaily.com/releases/2019/05/190501114629.htm

Why Cannabis Stems Inflammation

July 22, 2008

Science Daily/ETH Zurich/Swiss Federal Institute of Technology

Cannabis has long been accredited with anti-inflammatory properties. Researchers, however, have now discovered that it is not only the familiar psychoactive substances that are responsible for this; a compound we take in every day in vegetable nutriment also plays a significant role.

People not only rate cannabis sativa L. highly because of its intoxicating effects; it has also long been used as a medicinal plant. Although the plant has been scrutinized for years, surprising new aspects keep cropping up. For example, researchers from ETH Zurich and Bonn University examined a component in the plant’s essential oil that until then had largely been ignored and found it to have remarkable phar- macological effects. The findings open up interesting perspectives, especially for the prevention and treatment of inflammations.

Completely different molecule structure

 The hemp plant contains over 450 different substances, only three of which are responsible for its intoxicating effect. They activate the two receptors in the body CB1 and CB2. Whilst the CB1 receptor in the central nervous system influences perception, the CB2 receptor in the tissue plays a crucial role in inhibiting inflammation. If the receptor is activated, the cell releases fewer pro-inflammatory signal substances, or cytokines. The scientists have now discovered that the substance beta-carophyllene, which composes between 12 and 35 percent of the cannabis plant’s essential oil, activates the CB2 receptor selectively.

Unlike the three psychoactive substances, however, beta-carophyllene does not latch onto the CB1 receptor and consequently does not trigger the intoxicating effect. “Due to the various effects of cannabis, we had suspected for quite some time that other substances could come into play besides the psychoactive ones”, explains Jürg Gertsch from the Institute of Pharmaceutical Sciences at ETH Zurich. “However, astonishingly we didn’t know what substances these were until now.”

Gertsch finds it remarkable that beta-carophyllene has a very different molecule structure to that of the classical cannabinoids. “This is presumably why no one realized that the substance can also activate the CB2 receptor.” The scientists were not only able to prove that beta-carophyllene binds with the CB2 receptor in vitro but also in animal tests, where they treated mice that were suffering from an inflammatory swelling on their paws with orally administered doses of the substance. The swelling declined in up to 70 percent of the animals, even for deep doses. For mice lacking the gene for the CB2 receptor, however, the substance did not make an impact.

Common substance

 The results are encouraging for the prevention or treatment of ailments in which the CB2 receptor plays a positive role. However, Gertsch explains that we are still very much in the early stages on that score. That said, the scientist can conceive that some day the compound will not only help heal certain forms of inflammation, but also be instrumental in treating chronic illnesses, such as liver cirrhosis, Morbus Crohn, osteoarthritis and arteriosclerosis. In all of these diseases, the CB2 receptor and the associated endocannabinoid system play a crucial role.

The beauty is that beta-carophyllene is not only found in cannabis but also often in plants as a whole and we consume the substance in our diet. The non-toxic compound, which incidentally has been used as a food additive for many years, can be found in spice plants like oregano, basil, cinnamon and black pepper. “Whether we have found a new link between the vegetable diet and the prevention of so-called lifestyle diseases in our study remains to be seen in future studies”, adds Gertsch.

https://www.sciencedaily.com/releases/2008/07/080720222549.htm