Prenatal depression can alter child's brain connectivity, affect behavior

Weakened brain connections may mediate prenatal depression's influence on child behavior

August 10, 2020

Science Daily/Society for Neuroscience

Altered brain connectivity may be one way prenatal depression influences child behavior, according to new research in JNeurosci.

Up to one fifth of women experience depression symptoms during pregnancy, with unknown effects on the fetus. Prenatal depression is correlated with behavioral and developmental issues in the child, as well as an increased risk of developing depression at age 18. But how prenatal depression leads to these changes remains unclear.

Hay et al. studied 54 mother/child pairs. Mothers answered a survey about their depression symptoms at several points during their pregnancy. The research team employed diffusion MRI, an imaging technique that reveals the strength of structural connections between brain regions, to examine the children's white matter.

Greater prenatal depression symptoms were associated with weaker white matter connections between brain regions involved in emotional processing. This change could lead to dysregulated emotional states in the children and may explain why the children of depressed mothers have a higher risk of developing depression themselves. The weakened white matter was associated with increased aggression and hyperactivity in the male children. These findings highlight the need for better prenatal care to recognize and treat prenatal depression in order to support the mother and the child's development.

https://www.sciencedaily.com/releases/2020/08/200810141012.htm

Even mother's mild depressive symptoms affect the child's emotional well-being

September 23, 2019

Science Daily/National Institute for Health and Welfare

According to recent research, even mild long-term depressive symptoms among mothers are connected with emotional problems among small children such as hyperactivity, aggressiveness and anxiety.

The study investigated how the depressive symptoms of both parents affected the child by the age of two and five.

The father's depressive symptoms affected the child's emotional problems only if the mother was depressed as well. The mother's symptoms, however, affected the child even if the father was not depressed.

Moderate depressive symptoms can be observed in over 20% of parents in Finland. Most serious symptoms are seen in less than 9% of mothers and around 2.5% of fathers.

"Depression among parents both during and after pregnancy not only affects the person suffering from depression but also has a long-term impact on the well-being of the newborn child. Even in cases of mild depression, it is important that the symptoms are identified and the parents are offered support as early as possible, if necessary already during the pregnancy," explains Visiting Researcher Johanna Pietikäinen from the Finnish Institute for Health and Welfare (THL).

"In families, depression experienced by the mother has a key impact on the child's well-being. In Finland, the maternity clinic system functions well, but attention should be paid to depressive symptoms among mothers over a longer period: from the pregnancy through to the end of the child's first year of age," she adds.

One parent's depression also puts the other at risk

The depression of one parent is a factor that can put the other parent at risk of depression as well. In addition, depressive symptoms among mothers and fathers are quite long-term: they can start already during pregnancy and continue past the child's first birthday.

"It is important to monitor the mental well-being of both parents during pregnancy and after the birth of the child, and if one parent shows symptoms of depression then the symptoms of the other parent should also be examined. Currently, however, fathers' psychological well-being is not necessarily covered by depression questionnaires in maternity clinics, for example," Pietikäinen points out.

Prior depression is the most significant risk factor

Long-term depression is an indication that the depression may have been experienced already before the pregnancy. Previous experience of depression was, in fact, one of the key risk factors for moderate or severe depressive symptoms.

Other significant risk factors included sleep deprivation during pregnancy, stress, anxiety and a bad family environment. These most prominent risk factors were predictors for depression among both mothers and fathers.

https://www.sciencedaily.com/releases/2019/09/190923111249.htm