Cannabis reduces OCD symptoms by half in the short-term
October 20, 2020
Science Daily/Washington State University
People with obsessive-compulsive disorder, or OCD, report that the severity of their symptoms was reduced by about half within four hours of smoking cannabis, according to a Washington State University study.
The researchers analyzed data inputted into the Strainprint app by people who self-identified as having OCD, a condition characterized by intrusive, persistent thoughts and repetitive behaviors such as compulsively checking if a door is locked. After smoking cannabis, users with OCD reported it reduced their compulsions by 60%, intrusions, or unwanted thoughts, by 49% and anxiety by 52%.
The study, recently published in the Journal of Affective Disorders, also found that higher doses and cannabis with higher concentrations of CBD, or cannabidiol, were associated with larger reductions in compulsions.
"The results overall indicate that cannabis may have some beneficial short-term but not really long-term effects on obsessive-compulsive disorder," said Carrie Cuttler, the study's corresponding author and WSU assistant professor of psychology. "To me, the CBD findings are really promising because it is not intoxicating. This is an area of research that would really benefit from clinical trials looking at changes in compulsions, intrusions and anxiety with pure CBD."
The WSU study drew from data of more than 1,800 cannabis sessions that 87 individuals logged into the Strainprint app over 31 months. The long time period allowed the researchers to assess whether users developed tolerance to cannabis, but those effects were mixed. As people continued to use cannabis, the associated reductions in intrusions became slightly smaller suggesting they were building tolerance, but the relationship between cannabis and reductions in compulsions and anxiety remained fairly constant.
Traditional treatments for obsessive-compulsive disorder include exposure and response prevention therapy where people's irrational thoughts around their behaviors are directly challenged, and prescribing antidepressants called serotonin reuptake inhibitors to reduce symptoms. While these treatments have positive effects for many patients, they do not cure the disorder nor do they work well for every person with OCD.
"We're trying to build knowledge about the relationship of cannabis use and OCD because it's an area that is really understudied," said Dakota Mauzay, a doctoral student in Cuttler's lab and first author on the paper.
Aside from their own research, the researchers found only one other human study on the topic: a small clinical trial with 12 participants that revealed that there were reductions in OCD symptoms after cannabis use, but these were not much larger than the reductions associated with the placebo.
The WSU researchers noted that one of the limitations of their study was the inability to use a placebo control and an "expectancy effect" may play a role in the results, meaning when people expect to feel better from something they generally do. The data was also from a self-selected sample of cannabis users, and there was variability in the results which means that not everyone experienced the same reductions in symptoms after using cannabis.
However, Cuttler said this analysis of user-provided information via the Strainprint app was especially valuable because it provides a large data set and the participants were using market cannabis in their home environment, as opposed to federally grown cannabis in a lab which may affect their responses. Strainprint's app is intended to help users determine which types of cannabis work the best for them, but the company provided the WSU researchers free access to users' anonymized data for research purposes.
Cuttler said this study points out that further research, particularly clinical trials on the cannabis constituent CBD, may reveal a therapeutic potential for people with OCD.
This is the fourth study Cuttler and her colleagues have conducted examining the effects of cannabis on various mental health conditions using the data provided by the app created by the Canadian company Strainprint. Others include studies on how cannabis impacts PTSD symptoms, reduces headache pain, and affects emotional well-being.
https://www.sciencedaily.com/releases/2020/10/201020081733.htm
Domestic abuse linked to mental health problems in new mothers
- April 14, 2014
Science Daily/North Carolina State University
Domestic abuse is closely linked to postpartum mental health problems, including depression and post-traumatic stress disorder, in mothers, new research confirms. The research also found that specific types of abuse are associated with specific mental health problems. "The sheer scope of the mental health problems and types of abuse that we found tells us that we need to take a broader approach to tackling these issues," states a co-author. "And this is clearly not a 'lower class' problem -- medical professionals everywhere need to pay attention."
"We wanted to see whether and how intimate partner abuse -- physical, psychological and sexual -- influenced postpartum mental health in women, including problems such as depression, stress, anxiety, obsessive-compulsive disorder (OCD), and PTSD," says Dr. Sarah Desmarais, an assistant professor of psychology at NC State and lead author of a paper on the work.
The researchers interviewed 100 women from British Columbia who were largely from higher socioeconomic backgrounds and were not considered at high risk of postpartum mental health problems. The study participants were recruited to participate in a broad health and wellness study, which was not specifically focused on domestic abuse.
Sixty-one percent of the study participants reported symptoms of postpartum mental health problems within the first three months after childbirth. And 47 percent of the 100 women reported symptoms at "clinical" levels, meaning the symptoms were of at least moderate severity.
Eighty-four percent of the participants reported experiencing physical, psychological or sexual abuse at the hands of a partner prior to becoming pregnant. Seventy percent of the 100 participants reported some form of abuse by their romantic partner during pregnancy. These forms of abuse ranged from name-calling to rape and physical assault with a weapon.
"We found that women who had experienced abuse were more likely to suffer from postpartum mental health problems, and were much more likely to suffer from those problems if the abuse occurred during pregnancy," Desmarais says. "In addition, the more types of abuse they experienced, the more severe the mental health symptoms they reported. We also found that specific types of abuse were associated with specific problems."
The researchers found that psychological abuse -- verbal and emotional abuse -- was associated with stress and PTSD. Physical abuse was associated with depression, OCD and PTSD. Sexual abuse was associated with stress, depression and PTSD.
This means that some mental health problems could stem from any of the forms of abuse. For example, PTSD is associated with all three forms of abuse, but could be caused by any one of them; psychological abuse alone could lead to PTSD.
"This highlights the need for increased awareness of the prevalence of these issues, and the need for increased screening for abuse and mental health problems for pregnant women and new mothers," Desmarais says.
"The sheer scope of the mental health problems and types of abuse that we found tells us that we need to take a broader approach to tackling these issues," Desmarais adds. "And this is clearly not a 'lower class' problem -- medical professionals everywhere need to pay attention. But to do this effectively, we need to train doctors, nurses, and hospital staff in how to identify and respond to potential problems in this area."
http://www.sciencedaily.com/releases/2014/04/140414112439.htm