Sport and memory go hand in hand
September 23, 2020
Science Daily/Université de Genève
If sport is good for the body, it also seems to be good for the brain. By evaluating memory performance following a sport session, neuroscientists from the University of Geneva (UNIGE) demonstrate that an intensive physical exercise session as short as 15 minutes on a bicycle improves memory, including the acquisition of new motor skills. How? Through the action of endocanabinoids, molecules known to increase synaptic plasticity. This study, to be read in the journal Scientific Reports, highlights the virtues of sport for both health and education. School programmes and strategies aimed at reducing the effects of neurodegeneration on memory could indeed benefit from it.
Very often, right after a sporting exercise -- especially endurance such as running or cycling -- one feels physical and psychological well-being. This feeling is due to endocannabinoids, small molecules produced by the body during physical exertion. "They circulate in the blood and easily cross the blood-brain barrier. They then bind to specialise cellular receptors and trigger this feeling of euphoria. In addition, these same molecules bind to receptors in the hippocampus, the main brain structure for memory processing," says Kinga Igloi, lecturer in the laboratory of Professor Sophie Schwartz, at UNIGE Faculty of Medicine's Department of Basic Neurosciences, who led this work. "But what is the link between sport and memory? This is what we wanted to understand," she continues.
Intense effort is more effective
To test the effect of sport on motor learning, scientists asked a group of 15 young and healthy men, who were not athletes, to take a memory test under three conditions of physical exercise: after 30 minutes of moderate cycling, after 15 minutes of intensive cycling (defined as 80% of their maximum heart rate), or after a period of rest. "The exercise was as follows: a screen showed four points placed next to each other. Each time one of the dots briefly changed into a star, the participant had to press the corresponding button as quickly as possible," explains Blanca Marin Bosch, researcher in the same laboratory. "It followed a predefined and repeated sequence in order to precisely evaluate how movements were learnt. This is very similar to what we do when, for example, we learn to type on a keyboard as quickly as possible. After an intensive sports session, the performance was much better."
In addition to the results of the memory tests, the scientists observed changes in the activation of brain structures with functional MRI and performed blood tests to measure endocannabinoid levels. The different analyses concur: the faster individuals are, the more they activate their hippocampus (the brain area of memory) and the caudate nucleus (a brain structure involved in motor processes). Moreover, their endocannabinoid levels follow the same curve: the higher the level after intense physical effort, the more the brain is activated and the better the brain's performance. "These molecules are involved in synaptic plasticity, i.e. the way in which neurons are connected to each other, and thus may act on long-term potentiation, the mechanism for optimal consolidation of memory," says Blanca Marin Bosch.
Improving school learning or preventing Alzheimer's disease
In a previous study, the research team had already shown the positive effect of sport on another type of memory, associative memory. However, contrary to what is shown here, they had observed that a sport session of moderate intensity produced better results. It therefore shows that, as not all forms of memory use the same brain mechanisms, not all sports intensities have the same effects. It should be noted that in all cases, physical exercise improves memory more than inaction.
By providing precise neuroscientific data, these studies make it possible to envisage new strategies for improving or preserving memory. "Sports activity can be an easy to implement, minimally invasive and inexpensive intervention. For example, would it be useful to schedule a sports activity at the end of a school morning to consolidate memory and improve learning?"
Improving academic learning or preventing Alzheimer's disease
In a previous study, the research team had already shown the positive effect of sport on another type of memory, associative memory. But, contrary to what is shown here, they had observed that a sport session of moderate intensity, not high intensity, produced better results. Thus, just as not all forms of memory use the same brain mechanisms, not all sports intensities have the same effects. It should be noted that in all cases, physical exercise improves memory more than inaction.
By providing precise neuroscientific data, these studies make it possible to envisage new strategies for improving or preserving memory. "Sports activity can be an easy to implement, minimally invasive and inexpensive intervention. Would it be useful, for example, to plan a moment of sport at the end of a school morning to consolidate school learning," Kinga Igloi wonders, who, with her colleagues at Sophie Schwartz's laboratory, aims to achieve such practical objectives.
Neuroscientists are currently pursuing their work by studying memory disorders, and in particular by studying populations at high risk of developing Alzheimer's disease. "Some people as young as 25 years of age may experience subtle memory deficits characterised by overactivation of the hippocampus. We want to evaluate the extent to which sports practice could help compensate for these early deficits that are precursors to Alzheimer's disease.," conclude the authors.
https://www.sciencedaily.com/releases/2020/09/200923124616.htm
Exercise could slow withering effects of Alzheimer's
Imaging shows less brain deterioration in physically active people at high risk for dementia
September 17, 2019
Science Daily/UT Southwestern Medical Center
Exercising several times a week may delay brain deterioration in people at high risk for Alzheimer's disease, according to a study that scientists say merits further research to establish whether fitness can affect the progression of dementia.
Research from UT Southwestern found that people who had accumulation of amyloid beta in the brain -- a hallmark of Alzheimer's disease -- experienced slower degeneration in a region of the brain crucial for memory if they exercised regularly for one year.
Although exercise did not prevent the eventual spread of toxic amyloid plaques blamed for killing neurons in the brains of dementia patients, the findings suggest an intriguing possibility that aerobic workouts can at least slow down the effects of the disease if intervention occurs in the early stages.
"What are you supposed to do if you have amyloid clumping together in the brain? Right now doctors can't prescribe anything," said Dr. Rong Zhang, who led the clinical trial that included 70 participants ages 55 and older. "If these findings can be replicated in a larger trial, then maybe one day doctors will be telling high-risk patients to start an exercise plan. In fact, there's no harm in doing so now."
Reduced brain atrophy
The study published in the Journal of Alzheimer's Disease compared cognitive function and brain volume between two groups of sedentary older adults with memory issues: One group did aerobic exercise (at least a half-hour workout four to five times weekly), and another group did only flexibility training.
Both groups maintained similar cognitive abilities during the trial in areas such as memory and problem solving. But brain imaging showed that people from the exercise group who had amyloid buildup experienced slightly less volume reduction in their hippocampus -- a memory-related brain region that progressively deteriorates as dementia takes hold.
"It's interesting that the brains of participants with amyloid responded more to the aerobic exercise than the others," said Dr. Zhang, who conducted the trial at the Institute for Exercise and Environmental Medicine. "Although the interventions didn't stop the hippocampus from getting smaller, even slowing down the rate of atrophy through exercise could be an exciting revelation."
However, Dr. Zhang notes that more research is needed to determine how or if the reduced atrophy rate benefits cognition.
Elusive answers
The search for dementia therapies is becoming increasingly pressing: More than 5 million Americans have Alzheimer's disease, and the number is expected to triple by 2050.
Recent research has helped scientists gain a greater understanding of the molecular genesis of the disease, including a UT Southwestern discovery published last year that is guiding efforts to detect the condition before symptoms arise. Yet the billions of dollars spent on trying to prevent or slow dementia have yielded no proven treatments that would make an early diagnosis actionable for patients.
Fitness and brain health
Dr. Zhang is among a group of scientists across the world trying to determine if exercise may be the first such therapy.
His latest research builds upon numerous studies suggesting links between fitness and brain health. For example, a 2018 study showed that people with lower fitness levels experienced faster deterioration of vital nerve fibers in the brain called white matter. Research in mice has similarly shown exercise correlated with slower deterioration of the hippocampus -- findings that prompted Dr. Zhang to investigate whether the same effects could be found in people.
"I'm excited about the results, but only to a certain degree," Dr. Zhang said. "This is a proof-of-concept study, and we can't yet draw definitive conclusions."
Expanded research
Dr. Zhang is leading a five-year national clinical trial that aims to dig deeper into potential correlations between exercise and dementia.
The trial, which includes six medical centers across the country, involves more than 600 older adults (ages 60-85) at high risk of developing Alzheimer's disease. The study will measure whether aerobic exercise and taking specific medications to reduce high blood pressure and cholesterol can help preserve brain volume and cognitive abilities.
"Understanding the molecular basis for Alzheimer's disease is important," Dr. Zhang said. "But the burning question in my field is, 'Can we translate our growing knowledge of molecular biology into an effective treatment?' We need to keep looking for answers.
https://www.sciencedaily.com/releases/2019/09/190917124832.htm
How physical exercise prevents dementia
July 21, 2017
Science Daily/Goethe-Universität Frankfurt am Main
Physical exercise seems beneficial in the prevention of cognitive impairment and dementia in old age, numerous studies have shown. Now researchers have explored in one of the first studies worldwide how exercise affects brain metabolism.
Numerous studies have shown that physical exercise seems beneficial in the prevention of cognitive impairment and dementia in old age. Now researchers at Goethe University Frankfurt have explored in one of the first studies worldwide how exercise affects brain metabolism.
In order to further advance current state of knowledge on the positive influence of physical activity on the brain, gerontologists and sports physicians at Goethe University Frankfurt have examined the effects of regular exercise on brain metabolism and memory of 60 participants aged between 65 and 85 in a randomised controlled trial. Their conclusion: regular physical exercise not only enhances fitness but also has a positive impact on brain metabolism.
As the researchers report in the current issue of the medical journal Translational Psychiatry, they thoroughly examined all the participants in the SMART study (Sport and Metabolism in Older Persons, an MRT Study) by assessing movement-related parameters, cardiopulmonary fitness and cognitive performance. In addition, magnetic resonance tomography (MRT) and magnetic resonance spectroscopy (MRS) were used to measure brain metabolism and brain structure. Following this examination, the participants mounted an exercise bike three times a week over a period of 12 weeks. The 30-minute training sessions were individually adapted to each participant's performance level. The participants were examined again after the end of the programme in order to document the effects of this physical activity on brain metabolism, cognitive performance and brain structure. The researchers also investigated to what extent exercise had led to an improvement in the participants' physical fitness. The study was conducted by the Gerontology Department of the Institute of General Medicine (headed by Professor Johannes Pantel) and the Department of Sports Medicine (led by Professor Winfried Banzer).
As expected, physical activity had influenced brain metabolism: it prevented an increase in choline. The concentration of this metabolite often rises as a result of the increased loss of nerve cells, which typically occurs in the case of Alzheimer's disease. Physical exercise led to stable cerebral choline concentrations in the training group, whereas choline levels increased in the control group. The participants' physical fitness also improved: they showed increased cardiac efficiency after the training period. Overall, these findings suggest that physical exercise not only improves physical fitness but also protects cells.
https://www.sciencedaily.com/releases/2017/07/170721090107.htm