Psychedelic drug use could reduce psychological distress, suicidal thinking

March 9, 2015

Science Daily/Johns Hopkins Medicine

A history of psychedelic drug use is associated with less psychological distress and fewer suicidal thoughts, planning and attempts, according to new research from Johns Hopkins and the University of Alabama at Birmingham.

In a national survey of over 190,000 U.S. adults, lifetime use of certain psychedelic drugs was associated with a 19 percent reduced likelihood of psychological distress within the past month, a 14 percent reduced likelihood of suicidal thinking within the past year, a 29 percent reduced likelihood of suicide planning within the past year and a 36 percent reduced likelihood of attempting suicide within the past year. These results were published in the Journal of Psychopharmacology.

The findings suggest that some nonaddictive psychedelic drugs, while illegal, may hold promise for depression, and that these psychedelics' highly restricted legal status should be reconsidered to facilitate scientific studies, says study author Matthew W. Johnson, Ph.D., an associate professor of psychiatry and behavioral sciences at Johns Hopkins.

While the study authors are not encouraging the illicit use of these substances, "these could be breakthrough medical treatments that we've been ignoring for the past 30 years," Johnson says. "We need to carefully examine these cautiously and thoroughly."

For the study, researchers pooled data from five years of results of the National Survey on Drug Use and Health (2008 to 2012) to evaluate the relationship between a history of using certain nonaddictive psychedelic drugs and psychological distress and suicidality. The annual survey, administered by the Substance Abuse and Mental Health Services Administration of the U.S. Department of Health and Human Services, estimates the prevalence of substance use and mental illness in the general U.S. civilian noninstitutionalized population. The study focused on respondents with a history of using nonaddictive psychedelic drugs, which interact with certain serotonin receptors in the brain.

Of 191,382 respondents, 27,235 reported lifetime use of one or more of these psychedelics, primarily psilocybin and LSD. Lifetime use was concentrated among 26- to 64-year-olds and was more common among men; non-Hispanic whites and Native Americans/Alaska Natives; those with greater education and income; individuals who were divorced, separated or who had never married; those with greater self-reported engagement in risky behavior; and those who reported lifetime illicit use of other substances. Among users of these psychedelic drugs, only 240 said they never tried any other illicit drug.

In addition, 12,657 respondents reported psychological distress within the past month, 10,445 reported suicidal thinking within the past year, 3,157 reported suicidal planning within the past year and 1,716 reported suicidal attempt within the past year.

Using statistical methods that controlled for factors such as age, gender, income, education and other drug use, researchers found that lifetime use of these drugs was associated with a decreased likelihood of past-month psychological distress and past-year suicidal thinking, planning, and attempts. Conversely, lifetime use of other illicit substances was largely associated with an increase in these harms, "which is consistent with the fact that these other drugs, unlike classic psychedelics, are addictive," Johnson says.

The observational nature of the study cannot definitively show that psychedelics caused these effects, Johnson says, because those who chose to use psychedelics may have been psychologically healthier before using these drugs. However, the results probably reflect a benefit from psychedelics -- the study controlled for many relevant variables and found that, as the researchers expected, other drugs assessed in the study were linked to increased harms, he says. The use of nonaddictive psychedelic drugs may exacerbate schizophrenia or other psychotic disorders and can sometimes elicit feelings of anxiety, fear, panic and paranoia, which can lead to dangerous behavior, Johnson says. But these instances of individual harm, while serious, may not stand out in the survey data because they occur less often than the positive outcomes that some people experience.

"Our general societal impression of these drugs is they make people go crazy or are associated with psychological harm, but our data point to the potential psychological benefits from these drugs," he says. Current research at Johns Hopkins and several other universities is examining the therapeutic potential of one of the psychedelics, psilocybin, when administered in carefully controlled, monitored medical studies.

The study was co-authored by Peter S. Hendricks, Christopher B. Thorne, C. Brendan Clark and David W. Coombs of the University of Alabama at Birmingham.

https://www.sciencedaily.com/releases/2015/03/150309174507.htm

Classic psychedelic use protective with regard to psychological distress and suicidality

January 21, 2015

Science Daily/SAGE Publications

Classic psychedelics, such as LSD, psilocybin mushrooms and mescaline, previously have been shown to occasion lasting improvements in mental health. But researchers led by University of Alabama at Birmingham School of Public Health investigators wanted to advance the existing research and determine whether classic psychedelics might be protective with regard to suicidal thoughts and behaviors.

Approximately 30,000 lives in the United States are claimed by suicide every year, and more than 90 percent of victims have been diagnosed with mental illness, according to the National Alliance on Mental Illness.

Using data from more than 190,000 respondents of the National Survey on Drug Use and Health from 2008-2012, the researchers found that those who reported ever having used a classic psychedelic drug in their lifetime had a decreased likelihood of psychological distress in the past month, and decreased suicidal thinking, planning and attempts in the past year.

"Despite advances in mental health treatments, suicide rates generally have not declined in the past 60 years. Novel and potentially more effective interventions need to be explored," said Peter S. Hendricks, Ph.D., assistant professor in the Department of Health Behavior and lead study author. "This study sets the stage for future research to test the efficacy of classic psychedelics in addressing suicidality as well as pathologies associated with increased suicide risk (e.g., affective disturbance, addiction and impulsive-aggressive personality traits)."

Hendricks says the take-home message from this study is that classic psychedelics may hold great promise in the prevention of suicide and evaluating the therapeutic effectiveness of classic psychedelics should be a priority for future research.

https://www.sciencedaily.com/releases/2015/01/150121093544.htm