Aging: The natural stress reliever for many women

April 24, 2018

Science Daily/University of Michigan

While some research suggests that midlife is a dissatisfying time for women, other studies show that women report feeling less stressed and enjoy a higher quality of life during this period.

So, which is it? A recent University of Michigan study by Elizabeth Hedgeman, a doctoral graduate of the U-M School of Public Health, and colleagues found that perceived stress -- a measure of confidence, control and ability to cope with life's stressors -- did indeed decrease for most women over a 15-year span.

The study also found that menopausal status wasn't a factor, which challenges the notion that menopause is associated with higher stress and depression.

The results come from data collected from more than 3,000 women who were recruited between the ages of 42-53 for the Study of Women's Health Across the Nation.

Hedgeman's goal was to assess the effects of age, menopausal status and sociodemographics on stress over time. She did the work while in the lab of Sioban Harlow, professor of epidemiology at the U-M School of Public Health.

By the end of the study period, the mean age was 62 and stress declined with age across nearly all sociodemographic categories. Compared to similar black, white and Chinese women, stress decreased in a more attenuated fashion for Japanese women. After adjusting for other sociodemographic variables, race and ethnicity was a significant predictor of increased stress only for Japanese women.

Women with less education and increased financial hardship consistently reported higher levels of stress compared to their peers, but this difference diminished over time.

"The results suggested that even women with less education or more financial hardship reported less perceived stress over the midlife," Hedgeman said. "And then there's menopause.

"Our perception of stress decreased even through the menopausal transition, which suggests that menopause isn't a great bugaboo, perhaps in relation to the other events or experiences that we're having in the midlife."

Education, employment and financial hardship were stronger predictors of perceived stress over midlife than the menopause transition, and this may suggest that women experience the menopausal transition as a series of acute stressors (hot flashes, sleep disturbances) that can be muted by chronic, socioeconomic-based life stressors.

The only groups that reported increased perceived stress over the study were Hispanic and white women from New Jersey, but Hedgeman said these are outlier results that needed to be replicated. Additionally, there were extenuating circumstances at the New Jersey site that may have contributed.

Despite reporting decreased levels of stress throughout life, women who reported higher stress at the start of midlife continued to report higher stress levels than their peers as they aged. This is important because stress is a known health risk.

The study did not specifically examine the reasons for this decrease in perceived stress, but Hedgeman said that there could be both circumstantial and neurological causes -- children have moved out, professional goals are being met, or women might have hit a sweet spot before the next life challenges arise, such as chronic health conditions or aging parents.

Existing research also suggests that aging helps us regulate our emotions. "Perhaps things just don't bother us as much as we age, whether due to emotional experience or neurochemical changes. It's all worth exploring," Hedgeman said. Overall, the findings are good news for women transitioning through midlife, she said.

"The neat thing is that for most of us, our perception of stress decreases as we age through the midlife -- perhaps life itself is becoming less stressful, or maybe we're finally feeling at the top of our game, or maybe things just don't bother us the way they did," Hedgeman said. "But whatever the root reason, we're reporting less perceived stress as we age through the midlife and menopause."

The primary limitation of the study was the inability to understand perceived stress among women reporting the highest levels over time. Also, a disruption of operations at the New Jersey site, limited the number of visits to five, not 13 as with the other sites. Also, New Jersey was the only site that recruited Hispanic women.

Co-authors include: Rebecca Hasson, assistant professor of kinesiology and nutritional sciences; Carrie Karvonen-Gutierrez, assistant professor of epidemiology; and William Herman, professor of internal medicine and epidemiology.

https://www.sciencedaily.com/releases/2018/04/180424112834.htm

Longevity hormone is lower in stressed, depressed women

June 16, 2015

Science Daily/University of California - San Francisco

Women under chronic stress have significantly lower levels of klotho, a hormone that regulates aging and enhances cognition, researchers have found in a study comparing mothers of children on the autism spectrum to low-stress controls.

The researchers found that the women in their study with clinically significant depressive symptoms had even lower levels of klotho in their blood than those who were under stress but not experiencing such symptoms.

The study, published June 16, in Translational Psychiatry, is the first to show a relationship between psychological influences and klotho, which performs a wide variety of functions in the body.

"Our findings suggest that klotho, which we now know is very important to health, could be a link between chronic stress and premature disease and death," said lead author, Aric Prather, PhD, an assistant professor of psychiatry at UCSF. "Since our study is observational, we cannot say that chronic stress directly caused lower klotho levels, but the new connection opens avenues of research that converge upon aging, mental health, and age-related diseases."

Scientists know from their work in mice and worms that, when klotho is disrupted, it promotes symptoms of aging, such as hardening of the arteries and the loss of muscle and bone, and when klotho is made more abundant, the animals live longer.

In previous work, senior author Dena Dubal, MD, PhD, showed that a genetic variant carried by one in five people is associated with having more klotho in the bloodstream, better cognitive function and a larger region of the prefrontal cortex. Carriers also tend to live longer and have lower rates of age-related disease. Dubal and colleagues found that increasing klotho in mice boosted their cognition and increased resilience to Alzheimer-related toxins, suggesting a therapeutic role for klotho in the brain.

The current study included 90 high-stress caregivers and 88 low-stress controls, most of whom were in their 30s and 40s and otherwise healthy. Klotho is known to decline with age, but in this cross-sectional study of relatively young women, this decline only happened among the high-stress women. The low-stress women did not show a significant reduction in klotho with aging.

"Chronic stress transmits risk for bad health outcomes in aging, including cardiovascular and Alzheimer's disease," said Dubal, an assistant professor in the UCSF Department of Neurology and the David A. Coulter Endowed Chair in Aging and Neurodegenerative Disease. "It will be important to figure out if higher levels of klotho can benefit mind and body health as we age. If so, therapeutics or lifestyle interventions that increase the longevity hormone could have a big impact on people's lives."

The researchers hypothesized that lower levels of klotho could contribute to stress and depression, since klotho acts on a variety of cellular, molecular and neural pathways that link to stress and depression.

http://www.sciencedaily.com/releases/2015/06/150616155903.htm