New study links hearing loss with dementia in older adults

Findings highlight potential benefit of hearing aid

January 10, 2023

Science Daily/Johns Hopkins Bloomberg School of Public Health

A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health found that older adults with greater severity of hearing loss were more likely to have dementia, but the likelihood of dementia was lower among hearing aid users compared to non-users.

The findings, from a nationally representative sample of more than 2,400 older adults, are consistent with prior studies showing that hearing loss might be a contributing factor to dementia risk over time, and that treating hearing loss may lower dementia risk.

The findings are highlighted in a research letter published online January 10 in the Journal of the American Medical Association.

"This study refines what we've observed about the link between hearing loss and dementia, and builds support for public health action to improve hearing care access," says lead author Alison Huang, PhD, MPH, a senior research associate in the Bloomberg School's Department of Epidemiology and at the Cochlear Center for Hearing and Public Health, also at the Bloomberg School.

Hearing loss is a critical public health issue affecting two-thirds of Americans over 70. The growing understanding that hearing loss might be linked to the risk of dementia, which impacts millions, and other adverse outcomes has called attention to implementing possible strategies to treat hearing loss.

For the new study, Huang and colleagues analyzed a nationally representative dataset from the National Health and Aging Trends Study (NHATS). Funded by the National Institute on Aging, the NHATS has been ongoing since 2011, and uses a nationwide sample of Medicare beneficiaries over age 65, with a focus on the 90-and-over group as well as Black individuals.

The analysis covered 2,413 individuals, about half of whom were over 80 and showed a clear association between severity of hearing loss and dementia. Prevalence of dementia among the participants with moderate/severe hearing loss was 61 percent higher than prevalence among participants who had normal hearing. Hearing aid use was associated with a 32 percent lower prevalence of dementia in the 853 participants who had moderate/severe hearing loss.

The authors note that many past studies were limited in that they relied on in-clinic data collection, leaving out vulnerable populations that did not have the means or capacity to get to a clinic. For their study, the researchers collected data from participants through in-home testing and interviews.

How hearing loss is linked to dementia isn't yet clear, and studies point to several possible mechanisms. Huang's research adds to a body of work by the Cochlear Center for Hearing and Public Health examining the relationship between hearing loss and dementia.

The study authors expect to have a fuller picture of the effect of hearing loss treatment on cognition and dementia from their Aging and Cognitive Health Evaluation in Elders (ACHIEVE) Study. Results from the three-year randomized trial are expected this year.

https://www.sciencedaily.com/releases/2023/01/230110150943.htm

Experiences of daily stress decrease as people age

November 30, 2022

Science Daily/Penn State

Stories about how daily stress can negatively impact people's lives, from physical health to mental and emotional well-being, are frequently in the media. But there is good news about the experience of daily stress as people age. Results from a recent research study led by David Almeida, professor of human development and family studies at Penn State, showed that the number of daily stressors and people's reactivity to daily stressors decreases with age. The findings were published in the journal Developmental Psychology.

"There's something about growing old that leads to fewer stressors," said Almeida. "This could be the types of social roles that we fill as we age. As younger people, we may be juggling more, including jobs, families and homes, all of which create instances of daily stress. But as we age, our social roles and motivations change. Older people talk about wanting to maximize and enjoy the time they have."

The research team utilized data from the National Study of Daily Experiences (NSDE), a national study led by Almeida at Penn State that has collected comprehensive data on daily life from over 40,000 days in the lives of more than 3,000 adults across a 20-year time span, starting in 1995. Respondents were aged 25 to 74 when the study began and were invited to participate in the NSDE from the larger Midlife in the United States (MIDUS) project led by the University of Wisconsin-Madison Institute on Aging.

Respondents participated in telephone interviews that assessed daily levels of stress for eight consecutive days. These daily assessments were repeated at approximately nine-year intervals, providing a longitudinal daily diary across 20 years.

The researchers noted a decrease in the effects of daily stress both in the number of daily stressors that people reported, as well as their emotional reactivity to them. For example, 25-year-olds reported stressors on nearly 50% of days, while 70-year-olds reported stressors on only 30% of days.

In addition to the decrease in the number of daily stressors reported, Almeida and the research team also found that as people age, they are less emotionally reactive to daily stressors when they do happen.

"A 25-year-old is much grumpier on the days when they experience a stressor, but as we age, we really figure out how to decrease those exposures," said Almeida, who noted that daily stress steadily decreases until mid-50s, when people are the least affected by stress exposures.

While these findings show a decrease in reports of, and reactivity to, daily stressors into the mid-50s, Almeida notes that early indicators show that older age, into the late 60s and early 70s, may bring more challenges and a slight increase in instances of daily stress.

With this finding, Almeida is looking forward to the next round of data collection for MIDUS, which will be the first since the COVID-19 pandemic began in early 2020. This new round of data collection will allow Almeida and his team to assess the impact of the pandemic on daily stress reactivity.

The next round of data collection also will allow the team to further study how people grow and change during adulthood.

"Growing older from 35 to 65 is very different than growing older from 65 to 95," said Almeida. "We've started to see that in the data already, but this next round of data collection and analysis will give us an even greater understanding of what that looks like."

"At the end of the next post-pandemic data collection in a couple of years, I'll be in my early 60s, and when I started this project, I was in my late 20s," he continued. "My own development has occurred during this study of midlife, and it has been enlightening to watch these findings play out in my own life."

According to Almeida, we are all aging and growing older in various ways. How we age is depending on not only the challenges we face, but how we handle those challenges.

"A lot of my prior work looked at these small, daily stressors -- being late to a meeting, having an argument with a partner, caring for a sick child -- and found that our emotional responses to these events are predictive of later health and well-being, including chronic conditions, mental health and even mortality. With this new research, it's encouraging to see that as we age, we begin to deal with these stressors better. On average, the experience of daily stress won't get worse, but in fact get better."

https://www.sciencedaily.com/releases/2022/11/221130151532.htm

Daily multivitamin may improve cognition and possibly protect against decline

September 14, 2022

Science Daily/Atrium Health Wake Forest Baptist

Could taking a daily multivitamin help maintain cognitive health with aging and possibly prevent cognitive decline? According to new research from Wake Forest University School of Medicine, conducted in collaboration with Brigham and Women's Hospital in Boston, taking a daily supplement may improve cognition in older adults, but additional studies are needed to confirm these findings before any health recommendations are made. The study also showed that daily use of a cocoa extract supplement does not benefit cognition.

The findings were recently published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

According to the Alzheimer's Association, more than 6.5 million Americans are living with Alzheimer's disease, and 1 in 3 seniors die with the disease or another form of dementia.

"There's an urgent need for safe and affordable interventions to protect cognition against decline in older adults," said Laura D. Baker, Ph.D., professor of gerontology and geriatric medicine at Wake Forest University School of Medicine and co-principal investigator of the trial, along with Mark Espeland, Ph.D., professor of gerontology and geriatric medicine at Wake Forest University School of Medicine.

The COcoa Supplement and Multivitamin Outcomes Study for the Mind (COSMOS-Mind), funded by the National Institute on Aging of the National Institutes of Health, was an ancillary study to the COSMOS trial led by Brigham and Women's Hospital that randomized 21,442 men and women across the U.S. The study investigated whether taking a daily cocoa extract supplement or a daily multivitamin-mineral supplement reduces the risk of developing heart disease, stroke, cancer and other health outcomes.

According to Baker, cocoa extract is rich in compounds called flavanols, and past research suggests that these compounds may positively impact cognition. Baker also said that several micronutrients and minerals are needed to support normal body and brain function, and deficiencies in older adults may increase the risk for cognitive decline and dementia.

In COSMOS-Mind, researchers tested whether daily administration of cocoa extract versus placebo and a multivitamin-mineral versus placebo improved cognition in older adults. More than 2,200 participants, ages 65 and older, enrolled and were followed for three years. Participants completed tests over the telephone at baseline and annually to evaluate memory and other cognitive abilities.

"Our study showed that although cocoa extract did not affect cognition, daily multivitamin-mineral supplementation resulted in statistically significant cognitive improvement," Baker said. "This is the first evidence of cognitive benefit in a large longer-term study of multivitamin supplementation in older adults."

The researchers estimated that three years of multivitamin supplementation roughly translated to a 60% slowing of cognitive decline (about 1.8 years). The benefits were relatively more pronounced in participants with significant cardiovascular disease, which is important because these individuals are already at increased risk for cognitive impairment and decline.

"It's too early to recommend daily multivitamin supplementation to prevent cognitive decline," Baker said. "While these preliminary findings are promising, additional research is needed in a larger and more diverse group of people. Also, we still have work to do to better understand why the multivitamin might benefit cognition in older adults."

https://www.sciencedaily.com/releases/2022/09/220914102010.htm

Older adults with regular activity routines are happier and do better on cognitive tests

September 12, 2022

Science Daily/University of Pittsburgh

Older adults who consistently get up early and remain active throughout the day are happier and perform better on cognitive tests than those with irregular activity patterns, according to a new study led by University of Pittsburgh researchers.

The findings, published online in JAMA Psychiatry, suggest that patterns of activity -- not just activity intensity -- are important for healthy aging and mental health.

"There's something about getting going early, staying active all day and following the same routine each day that seems to be protecting older adults," said lead author Stephen Smagula, Ph.D., assistant professor of psychiatry and epidemiology at Pitt. "What's exciting about these findings is that activity patterns are under voluntary control, which means that making intentional changes to one's daily routine could improve health and wellness."

To learn more about daily activity patterns in U.S.-based older adults and identify links with mental health and cognition, Smagula and his team recruited 1,800 senior citizens aged over 65. Participants wore accelerometers -- movement-detecting devices often found in smartphones and exercise trackers -- on their wrist for seven days to measure activity, and they completed questionnaires to assess depression symptoms and cognitive function.

The analysis showed that 37.6% of participants rose early in the morning, stayed active throughout the day and had consistent daily routines.

"Many older adults had robust patterns: They get up before 7 a.m. on average, and they keep going; they stay active for 15 hours or so each day. They also tend to follow the same pattern day in, day out," said Smagula. "Lo and behold, those same adults were happier, less depressed and had better cognitive function than other participants."

Another group comprising 32.6% of participants similarly had consistent daily patterns but were active for an average of just 13.4 hours each day because they rose later in the morning or settled down earlier in the evening. This group had more depression symptoms and poorer cognition than the early risers.

"People often think about activity intensity being important for health, but it might be the duration of activity that matters more," said Smagula. "This is a different way of thinking about activity: You may not need to be sprinting or running a marathon but simply staying engaged with activities throughout the day."

The remaining 29.8% of participants had disrupted activity patterns in which periods of activity were erratic throughout the day and inconsistent across days. These adults had the highest rates of depression and performed worst on cognitive tests.

According to Smagula, the relationship between mental health and activity patterns likely goes both ways: Depression or cognitive impairment can make it harder to follow a consistent routine, and conversely, having a disrupted activity rhythm may worsen these symptoms.

"Our findings suggest that activity pattern disruption is very common and associated with health problems in older adults," explained Smagula. "The relationship is likely bi-directional, so the good news is we think that simple changes -- things everyone can try -- can restore regular activity patterns and doing so may improve health."

Now, Smagula and his team are developing interventions to test their hypothesis that modifying behaviors to develop more consistent daily routines will boost cognition and improve mental health in older adults.

Smagula said that the first step to developing a consistent routine and getting better sleep is waking up at the same time each day -- no matter how tired you are.

"The other thing is having a realistic plan to keep active through the whole day. This can be really hard -- especially if you're in a slump or recovering from an injury -- so it's important to be reasonable with yourself," he added. "A plan could include making a list of activities you enjoy and scheduling time to meet a friend or neighbor."

Time cues, called "zeitgebers," which help set the body's internal clock, can also assist in creating a stable routine. These include sunlight, exercise and eating. Pets, which often demand meals and walks at the same time each day, can be important social zeitgebers.

"Most people are aware of the importance of good sleep and exercise, but I think what's missing from this picture is the daily, or circadian, pattern of activity," said Smagula. "Having something to wake up for each morning and having a full day that you find purposeful and rewarding might be what's important for us sleeping well at night and aging well."

https://www.sciencedaily.com/releases/2022/09/220912163802.htm

Insomnia increases the likelihood of memory decline in older adults

Longitudinal study shows the psychological disorder is an important comorbidity for dementia and other cognitive impairments

September 6, 2022

Science Daily/Concordia University

A new Canadian study has found that older people with insomnia are at greater risk of developing memory decline and long-term cognitive impairment such as dementia.

The study, published in the journal SLEEP, is based on data from more than 26,000 participants of the Canadian Longitudinal Study on Aging, all aged between 45 and 85. The researchers compared completed self-reported evaluations of sleep and memory and neuropsychological testing in several cognitive domains from 2019 and a follow-up in 2022. Participants who reported worsening sleep quality in that three-year interval also had greater odds of reporting subjective memory decline.

"We found that insomnia specifically was related to worse memory performance compared to those who have some insomnia symptoms alone or no sleep problems at all," says the study's co-lead author Nathan Cross, a postdoctoral fellow at the Sleep, Cognition and Neuroimaging Lab. "This deficit in memory was specific, as we also looked at other cognitive function domains such as attention span multi-tasking. We only found differences in memory."

Jean-Louis Zhao at the Université de Montréal was the study's co-lead. Lisa Kakinami and Thanh Dang-Vu of the PERFORM Centre contributed to the study, as did Chun Yao and Ronald Postuma from McGill University and Julie Carrier and Nadia Gosselin at UdeM.

Big data and a sharp focus

Unlike previous studies on sleep quality, Cross says, this one benefits from its very large data set and its focus on sleep disorders. Insomnia, he points out, has been classified as a psychological disorder in the Diagnostic and Statistical Manual of Mental Disorders, the primary reference handbook used by physicians worldwide. Insomnia is not just tossing and turning for a time before bed: "A diagnosis requires symptoms of difficulty falling asleep, staying asleep or waking too early three nights a week over a period of three months. Additionally, those with insomnia must report that this sleep problem causes them difficulty in the daytime," Cross explains.

For this study, the researchers grouped their subjects into one of three categories: those who reported no sleep problems at the 2019 baseline, those who had some insomnia symptoms and those who developed probable insomnia. When they looked at the data from 2022 follow-up, those who had reported a worsening of sleep quality -- from no symptoms to some or probable insomnia, or from some symptoms to probable insomnia -- were more likely to report memory decline or have it diagnosed by their physician. They were also more likely to show higher prevalence of anxiety, depression, daytime sleepiness, have breathing interruptions during sleep, other sleep-related issues, smoking and a greater body mass index (BMI) score. All of these are considered risk factors for cognitive decline and dementia. Additionally, the study found that men with insomnia perform worse on memory tests than women, suggesting that older men may be at greater risk.

"However, there is some good news: sleep disorders like insomnia can be treated," Cross adds. "This highlights the importance of properly diagnosing and managing insomnia as early as possible in older adults. Adequately treating insomnia disorder might become an important preventive measure for cognitive decline and mitigate the incidence of dementia in later life."

https://www.sciencedaily.com/releases/2022/09/220906134013.htm

Poor heart health predicts premature brain aging

August 22, 2022

Science Daily/University College London

By estimating people's brain age from MRI scans using machine learning, a team led by UCL researchers has identified multiple risk factors for a prematurely ageing brain.

They found that worse cardiovascular health at age 36 predicted a higher brain age later in life, while men also tended to have older brains than women of the same age, as they report in The Lancet Healthy Longevity.

A higher brain age was associated with slightly worse scores on cognitive tests, and also predicted increased brain shrinkage (atrophy) over the following two years, suggesting it could be an important clinical marker for people at risk of cognitive decline or other brain-related ill health.

Lead author Professor Jonathan Schott (UCL Dementia Research Centre, UCL Queen Square Institute of Neurology) said: "We found that despite people in this study all being of very similar real ages, there was a very wide variation in how old the computer model predicted their brains to be. We hope this technique could one day be a useful tool for identifying people at risk of accelerated ageing, so that they may be offered early, targeted prevention strategies to improve their brain health."

The researchers applied an established MRI based machine learning model to estimate the brain age of members of the Alzheimer's Research UK-funded Insight 46 study, led by Professor Schott. Insight 46 study members are drawn from the Medical Research Council National Survey of Health and Development (NSHD) 1946 British Birth Cohort. As the participants had been a part of the study throughout their lives, the researchers were able to compare their current brain ages to various factors from across the life course.

The participants were all between 69 and 72 years old, but their estimated brain ages ranged from 46 to 93.

The researchers were able to explain roughly one third of the variability in brain age by reviewing various factors from across the life course.

People with worse cardiovascular health at age 36 or 69 had worse brain health, as did those with increased cerebrovascular disease on MRI (relating to blood flow and blood vessels in the brain). This aligns with a previous study led by Professor Schott finding that high blood pressure at age 36 predicted poorer brain health late in life.

The study did not identify any associations between childhood cognitive function, education level or socioeconomic status, and a prematurely ageing brain.

The researchers also found that higher brain age was associated with higher concentration of neurofilament light protein (NfL) in the blood. NfL elevation is thought to arise due to nerve cell damage and is increasingly being recognised as a useful marker of neurodegeneration.

Dr Sara Imarisio, Head of Research at Alzheimer's Research UK, said: "The Insight 46 study is helping reveal more about the complex relationship between the different factors influencing people's brain health throughout their life. Using machine learning, researchers in this study have uncovered yet more evidence that poorer heart health in midlife is linked to greater brain shrinkage in later life. We're incredibly grateful to the dedicated group of individuals who have contributed to research their entire lives making this work possible."

https://www.sciencedaily.com/releases/2022/08/220822184219.htm

What older adults do while they sit affects dementia risk

August 22, 2022

Science Daily/University of Southern California

Adults aged 60 and older who sit for long periods watching TV or other such passive, sedentary behaviors may be at increased risk of developing dementia, according to a new study by USC and University of Arizona researchers.

Their study also showed that the risk is lower for those who are active while sitting, such as when they read or use computers.

The study was published today in the journal Proceedings of the National Academy of Sciences. It also revealed that the link between sedentary behavior and dementia risk persisted even among participants who were physically active.

"It isn't the time spent sitting, per se, but the type of sedentary activity performed during leisure time that impacts dementia risk," said study author David Raichlen, professor of biological sciences and anthropology at the USC Dornsife College of Letters, Arts and Sciences.

"We know from past studies that watching TV involves low levels of muscle activity and energy use compared with using a computer or reading," he said. "And while research has shown that uninterrupted sitting for long periods is linked with reduced blood flow in the brain, the relatively greater intellectual stimulation that occurs during computer use may counteract the negative effects of sitting."

Researchers used self-reported data from the U.K. Biobank, a large-scale biomedical database of more than 500,000 participants across the United Kingdom, to investigate possible correlations between sedentary leisure activity and dementia in older adults.

More than 145,000 participants aged 60 and older -- all of whom did not have a diagnosis of dementia at the start of the project -- used touchscreen questionnaires to self-report information about their levels of sedentary behavior during the 2006-2010 baseline examination period.

After an average of nearly 12 years of follow-up, the researchers used hospital inpatient records to determine dementia diagnosis. They found 3,507 positive cases.

Then, the team adjusted for certain demographics (e.g., age, sex, race/ethnicity, employment type) and lifestyle characteristics (e.g., exercise, smoking and alcohol use, time spent sleeping and engaging in social contact) that could affect brain health.

The impact of physical activity, mental activity on risk

The results remained the same even after the scientists accounted for levels of physical activity. Even in individuals who are highly physically active, time spent watching TV was associated with increased risk of dementia, and leisure-time spent using a computer was associated with a reduced risk of developing dementia.

"Although we know that physical activity is good for our brain health, many of us think that if we are just more physically active during the day, we can counter the negative effects of time spent sitting," said study author Gene Alexander, professor of Psychology and Evelyn F. McKnight Brain Institute at the University of Arizona.

"Our findings suggest that the brain impacts of sitting during our leisure activities are really separate from how physically active we are," said Alexander, "and that being more mentally active, like when using computers, may be a key way to help counter the increased risk of dementia related to more passive sedentary behaviors, like watching TV."

Knowing how sedentary activities impact human health could lead to some improvements.

"What we do while we're sitting matters, " Raichlen added. "This knowledge is critical when it comes to designing targeted public health interventions aimed at reducing the risk of neurodegenerative disease from sedentary activities through positive behavior change."

https://www.sciencedaily.com/releases/2022/08/220822174914.htm

Low physical function after age 65 associated with future cardiovascular disease

August 31, 2022

Science Daily/American Heart Association

Among people older than age 65 who were assessed using a short physical function test, having lower physical function was independently associated with a greater risk of developing heart attack, heart failure and stroke, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

The Short Physical Performance Battery (SPPB) used in this study is considered a measure of physical function, which includes walking speed, leg strength and balance. This study examined physical function, which is different from physical fitness.

"While traditional cardiovascular disease risk factors such as high blood pressure, high cholesterol, smoking or diabetes are closely linked to cardiovascular disease, particularly in middle-aged people, we also know these factors may not be as predictive in older adults, so we need to identify nontraditional predictors for older adults," said study senior author Kunihiro Matsushita, M.D., Ph.D., an associate professor in the department of epidemiology at the Johns Hopkins Bloomberg School of Public Health and the Division of Cardiology at the Johns Hopkins School of Medicine in Baltimore. "We found that physical function in older adults predicts future cardiovascular disease beyond traditional heart disease risk factors, regardless of whether an individual has a history of cardiovascular disease."

The Atherosclerosis Risk in Communities (ARIC) study, an ongoing community-based cohort enrolled 15,792 participants, ages 45-64 years from 1987-1989, to investigate the causes for atherosclerotic disease (plaque or fatty buildup in the arteries). Yearly and semi-yearly (beginning in 2012) check-ins included phone calls and in-person clinic exams.

The present study evaluated health data from ARIC visit 5 (2011-2013; all participants were older than age 65) as a baseline, when the SPPB physical function test was first collected. The SPPB measured physical function to produce a score according to walking speed, speed of rising from a chair without using your hands and standing balance.

Researchers analyzed health data for 5,570 adults (58% women; 78% white adults; 22% Black adults), average age of 75 from 2011 to 2019. Using SPPB scores, the physical function of the participants was categorized into three groups: low, intermediate and high, based on their test performance.

Researchers examined the association of SPPB scores with future heart attack, stroke and heart failure, as well as the composite of the three, adjusting for major cardiovascular disease risk factors, such as high blood pressure, smoking, high cholesterol, diabetes and history of cardiovascular disease.

The study found:

• Among all participants, 13% had low, 30% had intermediate and 57% had high physical function scores.

• During the 8 years of the study, there were 930 participants with one or more confirmed cardiovascular events: 386 diagnosed with heart attack, 251 who had a stroke and 529 heart failure cases.

• Compared to adults with high physical function scores, those with low physical function scores were 47% more likely to experience at least one cardiovascular disease event, and those with intermediate physical function scores had a 25% higher risk of having at least one cardiovascular disease event.

• The association between physical function and cardiovascular disease remained after controlling for traditional cardiovascular disease risk factors such as age, high blood pressure, high cholesterol and diabetes.

• The physical function score improved the risk prediction of cardiovascular disease outcomes beyond traditional cardiovascular risk factors regardless of whether individuals had a history of cardiovascular disease or were healthy.

"Our findings highlight the value of assessing the physical function level of older adults in clinical practice," said study lead author Xiao Hu, M.H.S., a research data coordinator in the department of epidemiology at the Johns Hopkins Bloomberg School of Public Health. "In addition to heart health, older adults are at higher risk for falls and disability. The assessment of physical function may also inform the risk of these concerning conditions in older adults."

Falls and fear of falling in older adults are major health issues, and they are associated with high injury rates, high medical care costs and significant impact on quality of life. A 2022 American Heart Association scientific statement, Preventing and managing falls in adults with cardiovascular disease, advises medication adjustments, reassessing treatment plans, considering non-drug treatment options and properly managing heart rhythm disorders to reduce fall risks among elderly adults.

"Our study adds additional evidence to past research, which has demonstrated the importance of maintaining physical function at an older age," Matsushita said. "The next questions are: what is the best way for older adults to maintain physical function, and whether interventions that improve physical function can reduce cardiovascular disease risk?"

The study had several limitations. The study population included only white and Black adults but did not include people from other racial or ethnic groups (ARIC began enrollment in 1985, when participation among people from diverse racial and ethnic backgrounds was more limited). The study also didn't account for individuals whose lack of mobility might prevent them from getting assessed at a research clinic. Additional research will be required to confirm the findings in people from more diverse racial and ethnic groups and people who have even less physical function.

https://www.sciencedaily.com/releases/2022/08/220831073837.htm

Many types of leisure time activities may lower risk of death for older adults

August 24, 2022

Science Daily/NIH/National Cancer Institute

Older adults who participate weekly in many different types of leisure time activities, such as walking for exercise, jogging, swimming laps, or playing tennis, may have a lower risk of death from any cause, as well as death from cardiovascular disease and cancer, according to a new study led by researchers at the National Cancer Institute, part of the National Institutes of Health.

The findings suggest that it's important for older adults to engage in leisure time activities that they enjoy and can sustain, because many types of these activities may lower the risk of death, the authors wrote.

The findings appear August 24 in JAMA Network Open.

Using data from 272,550 adults between the ages of 59 and 82 who had completed questionnaires about their leisure-time activities as part of the NIH-AARP Diet and Health Study, the researchers looked at whether participating in equivalent amounts of seven different exercise and recreational activities -- including running, cycling, swimming, other aerobic exercise, racquet sports, golf, and walking for exercise -- was associated with lowered risk of death.

The researchers found that achieving the recommended amount of physical activity per week through any combination of these activities was associated with a 13% lower risk of death from any cause compared with no participation in these activities. When they looked at the role of each activity individually, playing racquet sports was associated with a 16% reduction in risk and running with a 15% reduction. However, all the activities investigated were similarly associated with lower risks of death.

The second edition of the Physical Activity Guidelines for Americans recommends that adults engage in 2.5 to 5 hours of moderate-intensity aerobic physical activity, or 1.25 to 2.5 hours of vigorous-intensity aerobic physical activity, each week.

The levels of activity by the most active individuals (those who exceeded the recommended levels of physical activity) were associated with even greater reductions in the risk of death, but there were diminishing returns as activity levels increased. Even people who did some recreational activity, though less than the recommended amount, had a 5% reduction in risk of death than those who did not participate in any of the activities studied.

These activities were also associated with a lower risk of death from cardiovascular disease and cancer. Playing racquet sports was associated with the greatest reduction in risk of cardiovascular deaths (27% reduction), while running was associated with the greatest reduction in risk of cancer deaths (19% reduction).

https://www.sciencedaily.com/releases/2022/08/220824120834.htm

Musical tests can detect mental deterioration in old age

Integration of music with analysis of electrical brain activity

August 17, 2022

Science Daily/Tel-Aviv University

Researchers at Tel Aviv University have developed a method that employs musical tests and a portable instrument for measuring brain activity to detect cognitive decline in old age. According to the researchers, the method, which is based on the measurement of 15 minutes of electrical activity in the brain while performing simple musical tasks, can be easily implemented by any staff member in any clinic, without requiring special training.

The researchers: "Our method enables routine monitoring and early detection of cognitive decline in order to provide treatment and prevent rapid, severe deterioration. Prophylactic tests of this kind are commonly accepted for a variety of physiological problems such as diabetes, high blood pressure or breast cancer; however, to date no method has yet been developed to enable routine, accessible monitoring of the brain for cognitive issues." The researchers further note that tests of this kind are particularly important in light of increasing longevity and associated growth of the elderly population.

The study was led at Tel Aviv University by PhD student Neta Maimon from the School of Psychological Sciences and the Buchmann-Mehta School of Music, and Lior Molcho from Neurosteer Ltd, headed by Prof. Nathan Intrator from the Blavatnik School of Computer Science and the Sagol School of Neuroscience. Other participants included: Adi Sasson, Sarit Rabinowitz, and Noa Regev-Plotnick from the Dorot-Netanya Geriatric Medical Center. The article was published in the journal Frontiers in Aging Neuroscience.

As part of the study, the researchers developed a groundbreaking method combining a portable device for the measurement and innovative analysis of electroencephalography (EEG), developed by Neurosteer, and a short musical test of about 12-15 minutes, developed by Neta Maimon. During the test, the subject is connected to the portable EEG device by means of a adhesive band with only three electrodes attached to the forehead. The subject performs a series of musical-cognitive tasks according to audible instructions given automatically through earphones. The tasks include short melodies played by different instruments, with the subjects instructed to perform various tasks on them at varying levels of difficulty. For example, pressing a button each time any melody is played or pressing it only when the violin plays. In addition, the test includes several minutes of musically guided meditation designed to bring the brain to a resting state, as this state is known to indicate cerebral functioning in various situations.

Neta Maimon, who specializes in musical cognition, explains that music has great influence on different centers in the brain. On the one hand, music is known to be a quick mood stimulant, particularly of positive emotion. On the other hand, in different situations, music can be cognitively challenging, activating the frontal parts of the brain, especially if we try to concentrate on different aspects of the music, and at the same time perform a particular task.

According to Maimon, if we combine these two capabilities, we can create cognitive tests that are quite complex, yet also pleasant and easy to perform. Furthermore, music that is positive and reasonably rhythmic will enhance concentration and performance of the task. Thus, for example, the famous "Mozart effect," showing improved performance on intelligence tests after listening to Mozart's music, actually has nothing to do with Mozart's music, but rather the fact that music creates a positive mood and stimulates us to a state that is optimal for performing intelligence and creativity tests.

Accordingly, the researchers hypothesized that with musical tools, it would also be possible to challenge the subjects to an extent that would enable testing of the brain's frontal activity as well as raising their spirits, thus enhancing their performance on the test while the overall experience is pleasant.

The study included an experiment at the Dorot-Netanya Geriatric Medical Center. Neta Maimon: "Anyone hospitalized at Dorot, or any other geriatric rehabilitation institution, undergoes a standard test called "mini-mental," designed to evaluate their cognitive condition as a routine part of the intake process. The test is conducted by an occupational therapist specially trained for it, and includes a variety of tasks. For example, enumerating the days of the week or months of the year backwards. In this test, up to 30 points can be accrued. A high score indicates normal cognition.

The experiment included the testing of 50 elderly people hospitalized at Dorot who scored 18-30 on the mini-mental test, indicating various levels of cognitive functioning. The participants performed the musical-cognitive tasks, administered automatically. The EEG device registered the electrical activity in the brain during the activity, with the results analyzed using machine learning technology. This allowed mathematical indices to be identified that were precisely correlated with the mini-mental test scores; in other words, we obtained new neuro-markers (brain markers) that may stand alone as indices of the subject's cognitive status.

Maimon adds: "We have actually succeeded in illustrating that music is indeed an effective tool for measuring brain activity. The brain activity and response times to tasks correlated to the subjects' cerebral conditions (correlating to the mini-mental score assigned to them). More importantly, all those who underwent the experiment reported that, on the one hand, it challenged the brain, but on the other it was very pleasant to perform."

The researchers conclude: "Our method enables the monitoring of cognitive capability and detection of cognitive decline already in the early stages. all by simple and accessible means, with a quick and easy test that can be conducted in any clinic. This method is of special importance today due to the increase in longevity and accelerated population growth, particularly among the elderly. Today, millions of people around the world already suffer or are liable to suffer soon from cognitive decline and its dire consequences, and their number will only increase in the coming decades. Our method could pave the way towards efficient cognitive monitoring of the general population, and thus detect cognitive decline in its early stages, when treatment and prevention of severe decline are possible. It is therefore expected to improve the quality of life of millions around the world."

Keren Primor Cohen, CEO, Ramot at TAU: "We are pleased that a company based on a technology developed at TAU continues its collaboration on creative and multidisciplinary research. Ramot will continue to promote and invest in novel technologies, as well as help TAU researchers to maximize their research's potential."

https://www.sciencedaily.com/releases/2022/08/220817104010.htm