Scientists find link between genes and ability to exercise

February 26, 2020

Science Daily/King's College London

A team of researchers have discovered a genetic mutation that reduces a patient's ability to exercise efficiently.

In a study published in The New England Journal of Medicine, a team including researchers from King's College London have found a link between a genetic mutation that affects cellular oxygen sensing and a patient's limited exercise capacity.

The team identified a patient who had a reduced rate of growth, persistent low blood sugar, a limited exercise capacity and a very high number of red blood cells.

The team carried out genetic and protein analysis of the patient, examined their respiratory physiology in simulated high altitude, measured their exercise capacity, and performed a series of metabolic tests.

The von Hippel-Lindau (VHL) gene is fundamental for cells to survive when oxygen availability is reduced. Following genetic analysis, an alteration on the VHL gene was identified and associated with impaired functionality in the patient's mitochondria, the powerhouse of the cell that uses oxygen to fuel cellular life. This reduced mitochondrial function efficiency limits the patient's aerobic exercise capacity compared to people without the mutation.

Dr Federico Formenti, School of Basic & Medical Biosciences, one of the leading authors of the study, comments: "The discovery of this mutation and the associated phenotype is exciting because it enables a deeper understanding of human physiology, especially in terms of how the human body senses and responds to reduced oxygen availability."

A new syndrome has been discovered that can alter the regulation of human metabolism and skeletal muscle function. This research puts the basis for the study of new mutations that affect the oxygen sensing pathways and the way these mutations are associated with the integrative function of the human body as a whole. Improving our understanding of these mechanisms may also contribute to the treatment of hypoxic conditions.

https://www.sciencedaily.com/releases/2020/02/200226171112.htm

Marine training may take more mental than physical grit

June 26, 2020

Science Daily/University of Southern California - Health Sciences

The United States military has a constant need for service members who can serve in elite and specialized military units, such as the Marine Corps. However, because the training courses for these forces is so rigorous, the dropout rate is high.

To help determine predictors of success or failure in elite military training, Leslie Saxon, MD, executive director of the USC Center for Body Computing, and fellow Center for Body Computing researchers monitored the physical and psychological activity of three consecutive classes of Marines and sailors enrolled in a 25-day specialized training course.

The results were published in the Journal of Medical Internet Research mHealth and uHealth.

A total of 121 trainees participated. Only slightly more than half (64) successfully completed the course.

Researchers found there was no correlation between finishing and performance on physical training standards, such as hikes or aquatic training. Physical markers such as heart rate or sleep status also did not play a role.

Rather, the biggest determinant was mental. Trainees who identified themselves as extroverted and having a positive affect -- the ability to cultivate a joyful, confident attitude -- were most likely to complete the course.

"These findings are novel because they identify traits not typically associated with military performance, showing that psychological factors mattered more than physical performance outcomes," says Saxon, who is also a cardiologist with Keck Medicine of USC and a professor of medicine (clinical scholar) at the Keck School of Medicine of USC.

Researchers were also able to pinpoint psychological stressors that triggered dropping out of the course. Trainees typically quit before a stressful aquatic training exercise or after reporting an increase in emotional or physical pain and a decrease in confidence. This led researchers to be able to predict who would drop out of the course one to two days in advance.

While Saxon has been studying human performance in elite athletes for 15 years, this was her first study involving the military. She partnered with the USC Institute for Creative Technologies, which has established military research programs, to run the study with a training company in Camp Pendleton, Calif. that trains Marines in amphibious reconnaissance. Typically, only around half of the participants finish the training.

The study authors collected baseline personality assessments of the trainees before the recruits began the course, assessing personality type, emotional processing, outlook on life and mindfulness. Researchers next provided subjects with an iPhone and Apple Watch, and a specially designed mobile application to collect continuous daily measures of trainees' mental status, physical pain, heart rate, activity, sleep, hydration and nutrition during training.

The mobile application also prompted trainees to answer daily surveys on emotional and physical pain, well-being and confidence in course completion and instructor support.

"This study, the first to collect continuous data from individuals throughout a training, suggests that there may be interventions the military can take to reduce the number of dropouts," says Saxon. "This data could be helpful in designing future training courses for Marines and other military units to increase the number of elite service members, as well as provide insights on how to help athletes and other high performers handle challenges."

Saxon is already testing whether or not various psychological interventions or coaching might encourage more trainees to stay the course.

https://www.sciencedaily.com/releases/2020/06/200626092737.htm

60 minutes of endurance training is enough to shift body clock in mice

June 15, 2020

Science Daily/The Physiological Society

New research published today in the Journal of Physiology shows that just one 60 minutes bout of exercise shifted the muscle clocks of mice by around an hour in either direction. If this research is replicated in humans, it makes a case for prescribing exercise for night-shift workers and for treating diseases like heart disease, both of which can result in disrupted clocks throughout the body.

Clocks exist in virtually all our cells to temporally coordinate cell specific functions. The setting of our clocks are sensitive to cues like changes in light throughout the day, or our time of eating. Researchers at the University of Florida found that the clocks in muscles of mice were "listening" to information from their muscle contractions during exercise.

This means that exercise is a cue for setting the clocks in muscles. The researchers determined this by studying mice that ran in different phases of the day: in the middle of their rest phase, an hour before starting their active phase, and in the middle of their active phase. Active and rest phases in mice are equivalent to day and night in humans. They then looked at how the amount of a primary clock protein changed over the course of multiple days following muscle contractions. Their results showed that depending on the timing of contractions the clocks shifted about an hour to either an earlier or later time and that this does not require circulating hormones or the central clock.

In other words, the timing of exercise during the day, can rewind or fast forward our muscle body clocks, so fine-tuning this could allow precise treatment of conditions where the body clocks either is running ahead or behind.

Researchers carried this research out in mice rather than humans as it would require multiple muscle biopsies, which are invasive procedures. Although this research has been done in mice thus far, it can be taken forward in patients without the need for clinical trials, as it calls for a prescription of exercise timing for certain conditions, such as heart disease.

Christopher Wolff, a co-first author on the study said:

"This research is really important because it highlights the effect exercise can have on our body clocks. If this is replicated in humans it means that night-shift workers can use exercise to help shift their body clocks. We may also be able to use exercise as a treatment for 'body clock disorders' that can occur in many chronic diseases such as heart disease."

https://www.sciencedaily.com/releases/2020/06/200615212715.htm

Aerobic exercise training linked to enhanced brain function

Regular aerobic exercise may decrease the likelihood of developing Alzheimer's disease

February 3, 2020

Science Daily/IOS Press

Individuals at risk for Alzheimer's disease (AD) because of family history or genetic predisposition who engaged in six months of aerobic exercise training improved their brain glucose metabolism and higher-order thinking abilities (e.g., planning and mental flexibility) called executive function; these improvements occurred in conjunction with increased cardiorespiratory fitness. The results of this study are published in a special issue of Brain Plasticity devoted to Exercise and Cognition.

Drugs currently available to treat AD have limited therapeutic capacity. At a time when both the human and monetary costs of the disease are projected to rise dramatically in the coming decades, there is a critical need to provide individuals with readily-deployable strategies that can decrease the likelihood of acquiring the disease or slow its progression. Researchers therefore investigated whether exercise training in asymptomatic individuals harboring risk for AD improves markers associated with AD.

"This study is a significant step toward developing an exercise prescription that protects the brain against AD, even among people who were previously sedentary," explained lead investigator Ozioma C. Okonkwo, PhD, of the Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health.

The study investigated 23 cognitively normal, relatively young older adults with a family history or genetic risk for AD. All patients had a sedentary lifestyle. They underwent a battery of assessments, including cardiorespiratory fitness testing, measurement of daily physical activity, brain glucose metabolism imaging (a measure of neuronal health), and cognitive function tests.

Half of the participants were randomly assigned to receive information about maintaining an active lifestyle but no further intervention. The other half participated in a moderate intensity treadmill training program with a personal trainer, three times per week for 26 weeks.

Compared to the participants maintaining their usual level of physical activity, individuals assigned to the active training program improved their cardiorespiratory fitness, spent less time sedentary after the training program ended, and performed better on cognitive tests of executive functioning (but not episodic memory). Executive function, an aspect of cognition that is known to decline with the progression of AD, comprises the mental processes enabling individuals to plan, focus attention, remember instructions, and juggle multiple tasks successfully. The participants' improved cardiorespiratory fitness was associated with increased brain glucose metabolism in the posterior cingulate cortex, an area of the brain linked to AD.

"This research shows that a lifestyle behavior -- regular aerobic exercise -- can potentially enhance brain and cognitive functions that are particularly sensitive to the disease. The findings are especially relevant to individuals who are at a higher risk due to family history or genetic predisposition," noted Dr. Okonkwo. The lead author on the study, Max Gaitán, MEd, of the Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, remarked that "an important next step would be to conduct a larger, more definitive, study. If these findings are replicated, they would have a tremendous impact on quality of later life, providing individuals with more years of independent living, active engagement with loved ones, and building memories."

https://www.sciencedaily.com/releases/2020/02/200203104450.htm

High and low exercise intensity found to influence brain function differently

Study suggests that exercise could play a role as a therapeutic strategy in neurological and psychiatric disorders

January 30, 2020

Science Daily/IOS Press

A new study shows for the first time that low and high exercise intensities differentially influence brain function. Using resting state functional magnetic resonance imaging (Rs-fMRI), a noninvasive technique that allows for studies on brain connectivity, researchers discovered that low-intensity exercise triggers brain networks involved in cognition control and attention processing, while high-intensity exercise primarily activates networks involved in affective/emotion processing. The results appear in a special issue of Brain Plasticity devoted to Exercise and Cognition.

"We believe that functional neuroimaging will have a major impact for unraveling body-brain interactions," said lead investigators Angelika Schmitt, MSc, and Henning Boecker, MD, Functional Neuroimaging Group, Department of Radiology, University Hospital Bonn, Bonn, Germany. "These novel methods allow us to 'look' directly into the brains of a group of athletes, and, maybe even more importantly, understand the dynamic changes in brain structure and function associated with the transition from a sedentary to a healthy lifestyle.

Twenty-five male athletes underwent individual assessments using an incremental treadmill test. On separate days they performed low- and high-intensity exercise bouts for 30 minutes. Before and after exercising, Rs-fMRI was used to examine functional connectivity of different brain regions that are linked to specific behavioral processes. Participants also completed a questionnaire to measure positive and negative mood before and after the exercise.

The behavioral data showed a significant increase in positive mood after both exercise intensities and no significant change in negative mood. The results of the Rs-fMRI tests showed that low-intensity exercise led to increased functional connectivity in networks associated with cognitive processing and attention. High-intensity exercise, on the other hand, led to increased functional connectivity in networks related to affective, emotional processes. High-intensity exercise also led to a decreased functional connectivity in networks associated with motor function.

The investigators note that this is the first study to report distinct effects of exercise intensity on specific functional networks within the brain at rest. Future research in this area will help provide neurobiological evidence about what type of exercise intensity is best suited for certain neurological or behavioral modulations and may pave the way for supportive clinical applications in patients or for enhancing brain functional plasticity.

https://www.sciencedaily.com/releases/2020/01/200130115430.htm

Long-distance skiers may have 'motor reserve' that can delay onset of Parkinson's disease

February 11, 2020

Science Daily IOS Press

To better understand the relationship between physical activity and Parkinson's Disease (PD) investigators in Sweden analyzed medical records of nearly 200,000 long-distance skiers who took part in the Vasaloppet cross-country ski race. They established that a physically active lifestyle is associated with close to a 30% reduced risk for PD, which might be explained by a motor reserve among the physically active, however, this dissipates as individuals age. Their results are published in the Journal of Parkinson's Disease (JPD).

Studies have shown the enormous benefits of exercise in many disorders including neurodegenerative diseases, but the reasons are not always clear. "Exercise seems to protect against the motor symptoms of PD but not necessarily against the brain damage caused by PD," explained co-lead investigator Tomas T. Olsson, MD, Department of Neurology, Skåne University Hospital, and Department of Experimental Medical Science, Experimental Dementia Research Unit, Lund University, Lund, Sweden.

"To understand the mechanisms behind the protective effects of exercise it is very important to establish whether exercise gives people a greater reserve or direct protection," noted co-lead investigator Martina Svensson, Department of Experimental Medical Science, Experimental Neuroinflammation Laboratory, Lund University, Lund, Sweden.

To investigate the degree to which physical activity is associated with long-term lower risk of PD and whether this association can be explained by physically active people being able to sustain more PD neuropathology before the onset of clinical symptoms, investigators analyzed long-term data about the incidence of PD among long-distance skiers. They followed 197,685 participants (median age 36 years; 38% women) in the Vasaloppet, an annual cross-country ski race of up to 90 km, from 1989 to 2010 and compared them to 197,684 age-matched non-skiers. Incidence of PD was taken from the Swedish National Patient Registry

Investigators found that the skiers were almost 30% less likely to develop PD than non-skiers. However, this dissipates with time and increasing age and results in diagnoses of PD among skiers matching the general population.

"We speculate that this would be consistent with the hypothesis that individuals who are physically well-trained have a greater motor reserve, which for every given level of Parkinson's brain damage would result in less motor symptoms thus delaying the diagnosis of PD," noted senior investigator Tomas Deierborg, PhD, Department of Experimental Medical Science, Experimental Neuroinflammation Laboratory, Lund University, Lund, Sweden. "This is analogous to the well-established concept of cognitive reserve in dementia in which the well-educated can sustain more brain pathology without clinical dementia. It highlights the importance of staying physically active throughout life in order to have a reserve to better cope when the frailties and diseases of old age inevitably arrive."

"If a person is physically active, it may be possible to maintain mobility for longer, despite the pathological changes in the brain," added Dr. Olsson.

JPD's Co-Editor-in-Chief Bastiaan R. Bloem, MD, PhD, Director, Radboudumc Center of Expertise for Parkinson & Movement Disorders, Nijmegen, The Netherlands, commented, "There is an enormous interest in developing new therapies that can help to lower the risk of developing PD. This present study by Olsson and colleagues is particularly exciting in that regard, because it suggests that a readily available intervention -- exercise -- can actually achieve this. The study also provides an explanation why exercise does not offer a complete protection against PD; it supports the motor reserve of the brain, and as such, probably helps to postpone rather than fully prevent the onset of manifest Parkinson symptoms."

PD is a slowly progressive disorder that affects movement, muscle control and balance. It is the second most common age-related neurodegenerative disorder affecting about 3% of the population by the age of 65 and up to 5% of individuals over 85 years of age.

https://www.sciencedaily.com/releases/2020/02/200211104915.htm

Tunes for training: High-tempo music may make exercise easier and more beneficial

Study is first to find that high-tempo music may increase the benefits of exercise and reduce perceived effort, particularly during endurance training

February 2, 2020

Science Daily Frontiers

A new study has shown that listening to high-tempo music increases the benefits of exercise for physical fitness and reduces the perceived effort involved. This effect was more pronounced in people performing endurance exercises, such as walking, than in those undergoing high-intensity training, such as weightlifting. The researchers hope that their findings could help people to improve their workout routines and exercise more efficiently.

With the start of the new year, gyms are at their busiest and many people are trying to establish a workout routine to improve their health. Getting an edge by making exercise easier and more effective could be the difference between success and guiltily returning to the warm embrace of the couch. What if doing something as simple as listening to a particular type of music could give you that edge?

A new study in Frontiers in Psychology is the first to show that listening to music at a higher tempo reduces the perceived effort involved in exercise and increases its benefits. These effects were greater for endurance exercises, such as walking, than for high-intensity exercises, such as weightlifting. The researchers hope that the findings could help people to increase and improve their exercise habits.

Many people listen to music while exercising and previous studies have documented some of the benefits. For instance, music can distract from fatigue and discomfort and increase participation in exercise. However, "how" we experience music is highly subjective, with cultural factors and personal preferences influencing its effects on individuals. Music is multifaceted with various aspects such as rhythm, lyrics and melody contributing to the experience.

Until now, researchers did not understand the specific properties of music that affect us during exercise, including which types of music are best suited to enhancing certain types of exercise. Understanding these specifics could help to unlock the full potential of music as an exercise enhancer.

The researchers set out to investigate the effect of the tempo of a piece of music on female volunteers performing either an endurance exercise (walking on a treadmill) or a high-intensity exercise (using a leg press).

The volunteers completed exercise sessions in silence, or while listening to pop music at different tempos. The researchers recorded a variety of parameters, including the volunteers' opinions about the effort required to complete the exercises and their heart rate while exercising, as a higher heart rate would mean that the exercise was more beneficial for physical fitness.

"We found that listening to high-tempo music while exercising resulted in the highest heart rate and lowest perceived exertion compared with not listening to music," explained Professor Luca P. Ardigò of the University of Verona in Italy. "This means that the exercise seemed like less effort, but it was more beneficial in terms of enhancing physical fitness."

These effects were more noticeable in volunteers completing the endurance exercise sessions, compared with those performing high-intensity exercises, suggesting that people performing endurance activities such as walking or running may receive the greatest benefit from listening to high-tempo music.

The researchers hope that these results will provide a simple way to improve levels of physical activity. While the current study involved a small group of volunteer subjects, larger studies in the future will be needed to continue exploring the nuances of how music affects our training.

"In the current study, we investigated the effect of music tempo in exercise, but in the future we would also like to study the effects of other music features such as genre, melody, or lyrics, on endurance and high intensity exercise," said Ardigò.

So, you could try playing fast-tempo music next time you hit the gym for a turbo-charged workout. Otherwise, it might at least get your foot tapping while you sit on the couch and eat chocolate.

https://www.sciencedaily.com/releases/2020/02/200202105147.htm

Esports organizations look to optimize player sleep

January 21, 2020

Science Daily/Flinders University

A study has used sleep tracking devices and mood measures (anxiety and depression) to determine how well esports athletes around the world sleep, and the effect this has on their mental health and well being. Preliminary results have shown that esports athletes are not getting the sleep (7-9hrs p/night for young adults aged 18-25) needed to best support optimal mental health and performance.

Esports has developed from relative obscurity into a billion dollar global industry, with an estimated 453 million viewers worldwide in 2019 -- and its set to get even bigger.

Despite esports rapid rise in popularity, there has been a notable lack of research available to support the needs of esports athletes but this is starting to change.

A study has used sleep tracking devices and mood measures (anxiety and depression) to determine how well esports athletes around the world sleep, and the effect this has on their mental health and well being.

Preliminary results have shown that esports athletes are not getting the sleep (7-9hours p/night for young adults aged 18-25) needed to best support optimal mental health and performance.

Leading the way is a multinational sleep team that includes clinical psychologist and PhD candidate Daniel Bonnar and Professor Michael Gradisar (Flinders University), Associate Professor Aly Suh and PhD candidate Sangha Lee (Sungshin University), Associate Professor Brandy Roane (University of North Texas) and Dr Daniel Blum (Stanford University).

Daniel Bonnar says innovative esports organisations around the world are now starting to actively look at how they could better support the health needs of their players, with sleep being apart of that.

"Global esports giant Gen.G from South Korea, and Perth-based Ground Zero were the first two teams to sign up to our project, which really demonstrated their commitment to promoting player wellness and performance" says Daniel.

Other esports organisations now involved include Kanga Esports and Gravitas from Australia.

"The benefit of working with esports organisations from different countries is that it allows us to develop a global view of the sleep habits of esports athletes," Daniel added.

As to the study's findings, preliminary results have shown that esports athletes are not getting the sleep (7-9hrs p/night for young adults aged 18-25) needed to best support optimal mental health and performance.

"From the data we've collected so far, we can see a trend that many esports athletes obtain less than 7hrs of sleep p/night, have a tendency to want to sleep and wake very late, with mood impacted as a result in some players," says Professor Michael Gradisar. "Although these late sleeping patterns might be ok for some players, for others it could be an issue with conflicting daytime commitments encroaching on their sleep schedule."

Phase two of the project will be to improve players' sleep using a sleep intervention designed to address their specific sleep needs.

"If we can improve the sleep of esports athletes, this will translate into enhanced well being which can only be helpful for performance as well," says Professor Gradisar.

Gravitas team owner Sean Callanan says "I'm looking forward to Gravitas players understanding the importance of sleep and how it can affect their performance for practice and on game days. I know it's become a focus in traditional pro-sports, so esports should be following their lead."

https://www.sciencedaily.com/releases/2020/01/200121123958.htm

Keep exercising: New study finds it's good for your brain's gray matter

January 2, 2020

Science Daily/Mayo Clinic

A study provides new evidence of an association between cardiorespiratory fitness and brain health, particularly in gray matter and total brain volume -- regions of the brain involved with cognitive decline and aging.

Cardiorespiratory exercise -- walking briskly, running, biking and just about any other exercise that gets your heart pumping -- is good for your body, but can it also slow cognitive changes in your brain?

A study in Mayo Clinic Proceedings from the German Center for Neurodegenerative Diseases provides new evidence of an association between cardiorespiratory fitness and brain health, particularly in gray matter and total brain volume -- regions of the brain involved with cognitive decline and aging.

Brain tissue is made up of gray matter, or cell bodies, and filaments, called white matter, that extend from the cells. The volume of gray matter appears to correlate with various skills and cognitive abilities. The researchers found that increases in peak oxygen uptake were strongly associated with increased gray matter volume.

The study involved 2,013 adults from two independent cohorts in northeastern Germany. Participants were examined in phases from 1997 through 2012. Cardiorespiratory fitness was measured using peak oxygen uptake and other standards while participants used an exercise bike. MRI brain data also were analyzed.

The results suggest cardiorespiratory exercise may contribute to improved brain health and decelerate a decline in gray matter. An editorial by three Mayo Clinic experts that accompanies the Mayo Clinic Proceedings study says the results are "encouraging, intriguing and contribute to the growing literature relating to exercise and brain health."

Ronald Petersen, M.D., Ph.D., a Mayo Clinic neurologist and first author of the editorial, says the most striking feature of the study is the measured effect of exercise on brain structures involved in cognition, rather than motor function. "This provides indirect evidence that aerobic exercise can have a positive impact on cognitive function in addition to physical conditioning," he says. "Another important feature of the study is that these results may apply to older adults, as well. There is good evidence for the value of exercise in midlife, but it is encouraging that there can be positive effects on the brain in later life as well."

Dr. Petersen is the Cora Kanow Professor of Alzheimer's Disease Research and the Chester and Debbie Cadieux Director of the Mayo Clinic Alzheimer's Disease Research Center.

The study's finding of higher gray matter volume associated with cardiorespiratory exercise are in brain regions clinically relevant for cognitive changes in aging, including some involved in Alzheimer's disease. The editorial calls those associations interesting but cautions against concluding that cardiorespiratory fitness correlations would affect Alzheimer's disease.

"This is another piece of the puzzle showing physical activity and physical fitness is protective against aging-related cognitive decline," says Michael Joyner, M.D., a Mayo Clinic anesthesiologist and physiologist, and editorial co-author. "There's already good epidemiological evidence for this, as well as emerging data showing that physical activity and fitness are associated with improved brain blood vessel function. This paper is important because of the volumetric data showing an effect on brain structure."

Dr. Joyner is the Frank R. and Shari Caywood Professor at Mayo Clinic.

Long-term studies on the relationship between exercise and brain health are needed, which will be costly and logistically challenging to produce. "Nevertheless, these data are encouraging," says Clifford Jack Jr., M.D., a Mayo Clinic neuroradiologist and co-author of the editorial. "The findings regarding cardiorespiratory fitness and certain brain structures are unique."

Dr. Jack is the Alexander Family Professor of Alzheimer's Disease Research.

According to Mayo Clinic experts, moderate and regular exercise -- about 150 minutes per week -- is recommended. Good cardiorespiratory fitness also involves:

Not smoking

Following healthy eating habits

Losing weight or maintaining a healthy weight level

Managing blood pressure and avoiding hypertension

Controlling cholesterol levels

Reducing blood sugar, which over time can damage your heart and other organs

University Medicine Greifswald, Germany, also was part of the research project. Katharina Wittfeld, Ph.D., a researcher at the German Center for Neurodegenerative Disease, is first author.

https://www.sciencedaily.com/releases/2020/01/200102094314.htm

Eating disorders linked to exercise addiction

New study is first to calculate risk factor

January 28, 2020

Science Daily/Anglia Ruskin University

New research shows that exercise addiction is nearly four times more common amongst people with an eating disorder.

The study, led by Mike Trott of Anglia Ruskin University (ARU), was published this month in the journal Eating and Weight Disorders -- Studies on Anorexia, Bulimia and Obesity.

The research is the first to measure rates of exercise addiction in groups of people with and without the characteristics of an eating disorder, The meta-analysis examined data from 2,140 participants across nine different studies, including from the UK, the US, Australia and Italy.

It found that people displaying characteristics of an eating disorder are 3.7 times more likely to suffer from addiction to exercise than people displaying no indication of an eating disorder.

Trott, a PhD researcher in Sport Science at Anglia Ruskin University (ARU), said: "It is known that those with eating disorders are more likely to display addictive personality and obsessive-compulsive behaviours. We are also aware that having an unhealthy relationship with food often means an increased amount of exercising, but this is the first time that a risk factor has been calculated.

"It is not uncommon to want to improve our lifestyles by eating healthier and doing more exercise, particularly at the start of the year. However, it is important to moderate this behaviour and not fall victim to 'crash diets' or anything that eliminates certain foods entirely, as these can easily lead to eating disorders.

"Our study shows that displaying signs of an eating disorder significantly increases the chance of an unhealthy relationship with exercise, and this can have negative consequences, including mental health issues and injury.

"Health professionals working with people with eating disorders should consider monitoring exercise levels as a priority, as this group have been shown to suffer from serious medical conditions as a result of excessive exercise, such as fractures, increased rates of cardiovascular disease in younger patients, and increased overall mortality."

https://www.sciencedaily.com/releases/2020/01/200128114642.htm

Play sports for a healthier brain

Even football, soccer, hockey athletes have healthier brains

Science Daily/December 9, 2019

Northwestern University

There have been many headlines in recent years about the potentially negative impacts contact sports can have on athletes' brains. But a new Northwestern University study shows that, in the absence of injury, athletes across a variety of sports -- including football, soccer and hockey -- have healthier brains than non-athletes.

"No one would argue against the fact that sports lead to better physically fitness, but we don't always think of brain fitness and sports," said senior author Nina Kraus, the Hugh Knowles Professor of Communication Sciences and Neurobiology and director of Northwestern's Auditory Neuroscience Laboratory (Brainvolts). "We're saying that playing sports can tune the brain to better understand one's sensory environment."

Athletes have an enhanced ability to tamp down background electrical noise in their brain to better process external sounds, such as a teammate yelling a play or a coach calling to them from the sidelines, according to the study of nearly 1,000 participants, including approximately 500 Northwestern Division I athletes.

Kraus likens the phenomenon to listening to a DJ on the radio.

"Think of background electrical noise in the brain like static on the radio," Kraus said. "There are two ways to hear the DJ better: minimize the static or boost the DJ's voice. We found that athlete brains minimize the background 'static' to hear the 'DJ' better."

The study will be published Dec. 9 in the journal Sports Health.

"A serious commitment to physical activity seems to track with a quieter nervous system," Kraus said. "And perhaps, if you have a healthier nervous system, you may be able to better handle injury or other health problems."

The findings could motivate athletic interventions for populations that struggle with auditory processing. In particular, playing sports may offset the excessively noisy brains often found in children from low-income areas, Kraus said.

This is the latest study from the neural processing of sound in sports concussions and contact sports partnership, a five-year, National Institutes of Health-funded research collaboration between Brainvolts and Northwestern University Athletics, which launched last year. The study examined the brain health of 495 female and male Northwestern student athletes and 493 age- and sex-matched control subjects.

Kraus and her collaborators delivered speech syllables to study participants through earbuds and recorded the brain's activity with scalp electrodes. The team analyzed the ratio of background noise to the response to the speech sounds by looking at how big the response to sound was relative to the background noise. Athletes had larger responses to sound than non-athletes, the study showed.

Like athletes, musicians and those who can speak more than one language also have an enhanced ability to hear incoming sound signals, Kraus said. However, musicians' and multilinguals' brains do so by turning up the sound in their brain versus turning down the background noise in their brain.

"They all hear the 'DJ' better but the musicians hear the 'DJ' better because they turn up the 'DJ,' whereas athletes can hear the 'DJ' better because they can tamp down the 'static,'" Kraus said.

https://www.sciencedaily.com/releases/2019/12/191209080502.htm

Mental practice may improve golfers' putting performance

Science backs-up Arnold Palmer's golf theory

November 27, 2019

Science Daily/University of Limerick

Researchers from Lero, the Science Foundation Ireland Research Centre for Software, hosted at University of Limerick (UL), are lending support to Arnold Palmer's famous assertion that golf is predominantly played in "the six inches between the ears."

According to research by Lero and UL, kinaesthetic ability, which is an individual's ability to feel an action without actually performing it, may improve their golf game. Niall Ramsbottom, a researcher at Lero and UL, explained that recent research carried out by the team indicates that with mental practice, golfers can improve their putting.

"Our results indicate that a form of mental practice, i.e. the combination of action observation and motor imagery, may enhance the golf putting ability of experienced golfers," he said, "and that could well mean a reduction in a golfer's handicap."

The research was carried out at the Physical Education and Sports Sciences Department at University of Limerick, in conjunction with Lero. The findings for the work carried out by Mr Ramsbottom and his fellow researchers, Eoghan McNeill, Dr Adam Toth and Dr Mark Campbell, show that golfers who already had a good 'feel" for putting, may benefit the most from this mental practice.

"We found, kinaesthetic imagery ability -- an individual's ability to imagine the feel of an action without actually performing it -- may have an important role in determining the effectiveness of the exercise on putting performance. Putting is a feel-based motor skill and our research suggests that those with good kinaesthetic imagery ability may perform better following this mental practice technique," explained Mr Ramsbottom.

"The findings suggest that simply viewing a video of another performing an action may bolster one's ability to imagine and subsequently perform that action," he said.

Putting ability is crucial in golf as approximately 40% of golf strokes are taken with the putter.

"Furthermore, golf putting ability was found to be one of the most important skills in determining earnings on the Professional Golf Association (PGA) Tour," the report, published in Psychology of Sport and Exercise, states, citing previously conducted research.

In undertaking the research, 44 right-handed, skilled male golfers from the Limerick area were recruited. Each of the participants was required to hold a current Golfing Union of Ireland handicap, and could not have participated on any such research previously. In a laboratory environment, the golfers completed 40 putts with instructions to 'make the ball stop as close to the target as possible'. A three-dimensional ultrasound camera was used to record the putting and statistical analysis was conducted, using specialised software.

"A subset of golfers looked at an action observation video which consisted of an expert golfer performing the putting task in the same lab environment. They did so while listening to a motor imagery script consisting of short sentences describing key visual and kinaesthetic feelings associated with performing the putting the task. Having completed these simple exercises, the golfers who were found to have better kinaesthetic imagery (KI) ability benefited more from the mental practice intervention than those with poorer KI ability," explained Mr Ramsbottom.

https://www.sciencedaily.com/releases/2019/11/191127090208.htm

Any amount of running linked to significantly lower risk of early death

Any amount of running linked to significantly lower risk of early death

November 4, 2019

Science Daily/BMJ

Any amount of running is linked to a significantly lower risk of death from any cause, finds a pooled analysis of the available evidence, published online in the British Journal of Sports Medicine.

If more people took up running -- and they wouldn't have to run far or fast -- there would likely be substantial improvements in population health and longevity, conclude the researchers.

It's not clear how good running is for staving off the risk of death from any cause and particularly from cardiovascular disease and cancer, say the researchers.

Nor is it clear how much running a person needs to do to reap these potential benefits, nor whether upping the frequency, duration, and pace -- in other words, increasing the 'dose' -- might be even more advantageous.

To try and find out, the researchers systematically reviewed relevant published research, conference presentations, and doctoral theses and dissertations in a broad range of academic databases.

They looked for studies on the association between running/jogging and the risk of death from all causes, cardiovascular disease, and cancer.

They found 14 suitable studies, involving 232,149 people, whose health had been tracked for between 5.5 and 35 years. During this time, 25,951 of the study participants died.

When the study data were pooled, any amount of running was associated with a 27% lower risk of death from all causes for both sexes, compared with no running.

And it was associated with a 30% lower risk of death from cardiovascular disease, and a 23% lower risk of death from cancer.

Even small 'doses' -- for example, once weekly or less, lasting less than 50 minutes each time, and at a speed below 6 miles (8 km) an hour, still seemed to be associated with significant health/longevity benefits.

So running for 25 minutes less than the recommended weekly duration of vigorous physical activity could reduce the risk of death. This makes running a potentially good option for those whose main obstacle to doing enough exercise is lack of time, suggest the researchers.

But upping 'the dose' wasn't associated with a further lowering of the risk of death from any cause, the analysis showed.

This is an observational study, and as such, can't establish cause. And the researchers caution that the number of included studies was small and their methods varied considerably, which may have influenced the results.

Nevertheless, they suggest that any amount of running is better than none, concluding: "Increased rates of participation in running, regardless of its dose, would probably lead to substantial improvements in population health and longevity."

https://www.sciencedaily.com/releases/2019/11/191104190653.htm

Increase health benefits of exercise by working out before breakfast

October 18, 2019

Science Daily/University of Bath

Exercising before eating breakfast burns more fat, improves how the body responds to insulin and lowers people's risk of type 2 diabetes and cardiovascular disease.

According to a new study, published in the Journal of Clinical Endocrinology and Metabolism, health scientists at the Universities of Bath and Birmingham found that by changing the timing of when you eat and exercise, people can better control their blood sugar levels.

The six-week study, which involved thirty men classified as obese or overweight and compared results from two intervention groups (who ate breakfast before / after exercise) and a control group (who made no lifestyle changes), found that people who performed exercise before breakfast burned double the amount of fat than the group who exercised after breakfast.

They found that increased fat use is mainly due to lower insulin levels during exercise when people have fasted overnight, which means that they can use more of the fat from their fat tissue and the fat within their muscles as a fuel. To test proof-of-principle the initial study involved only men, but future studies will look to translate these findings for different groups including women.

Whilst this did not lead to any differences for weight loss over six weeks, it did have 'profound and positive' effects on their health because their bodies were better able to respond to insulin, keeping blood sugar levels under control and potentially lowering the risk of diabetes and heart disease.

Building on emerging evidence that the timing of meals in relation to exercise can shift how effective exercise is, the team behind this study wanted to focus on the impact on the fat stores in muscles for individuals who either worked out before or after eating and the effect this had on insulin response to feeding.

Dr Javier Gonzalez of the Department for Health at the University of Bath explained: "Our results suggest that changing the timing of when you eat in relation to when you exercise can bring about profound and positive changes to your overall health.

"We found that the men in the study who exercised before breakfast burned double the amount of fat than the group who exercised after. Importantly, whilst this didn't have any effect on weight loss, it did dramatically improve their overall health.

"The group who exercised before breakfast increased their ability to respond to insulin, which is all the more remarkable given that both exercise groups lost a similar amount of weight and both gained a similar amount of fitness. The only difference was the timing of the food intake."

Over the six-week trial, the scientists found that the muscles from the group who exercised before breakfast were more responsive to insulin compared to the group who exercised after breakfast, in spite of identical training sessions and matched food intake. The muscles from those who exercised before breakfast also showed greater increases in key proteins, specifically those involved in transporting glucose from the bloodstream to the muscles.

For the insulin response to feeding after the 6-week study, remarkably, the group who exercised after breakfast were in fact no better than the control group.

Co-author Dr Gareth Wallis of the University of Birmingham added: "This work suggests that performing exercise in the overnight-fasted state can increase the health benefits of exercise for individuals, without changing the intensity, duration or perception of their effort. We now need to explore the longer-term effects of this type of exercise and whether women benefit in the same way as men."

https://www.sciencedaily.com/releases/2019/10/191018080619.htm