Traffic pollution impairs brain function

First-in-the-world study suggests that even brief exposure to air pollution has rapid impacts on the brain

January 24, 2023

Science Daily/University of British Columbia

A new study by researchers at the University of British Columbia and the University of Victoria has shown that common levels of traffic pollution can impair human brain function in only a matter of hours.

The peer-reviewed findings, published in the journal Environmental Health, show that just two hours of exposure to diesel exhaust causes a decrease in the brain's functional connectivity -- a measure of how The study provides the first evidence in humans, from a controlled experiment, of altered brain network connectivity induced by air pollution.

"For many decades, scientists thought the brain may be protected from the harmful effects of air pollution," said senior study author Dr. Chris Carlsten, professor and head of respiratory medicine and the Canada Research Chair in occupational and environmental lung disease at UBC. "This study, which is the first of its kind in the world, provides fresh evidence supporting a connection between air pollution and cognition."

For the study, the researchers briefly exposed 25 healthy adults to diesel exhaust and filtered air at different times in a laboratory setting. Brain activity was measured before and after each exposure using functional magnetic resonance imaging (fMRI).

The researchers analyzed changes in the brain's default mode network (DMN), a set of inter-connected brain regions that play an important role in memory and internal thought. The fMRI revealed that participants had decreased functional connectivity in widespread regions of the DMN after exposure to diesel exhaust, compared to filtered air.

"We know that altered functional connectivity in the DMN has been associated with reduced cognitive performance and symptoms of depression, so it's concerning to see traffic pollution interrupting these same networks," said Dr. Jodie Gawryluk, a psychology professor at the University of Victoria and the study's first author. "While more research is needed to fully understand the functional impacts of these changes, it's possible that they may impair people's thinking or ability to work."

Taking steps to protect yourself

Notably, the changes in the brain were temporary and participants' connectivity returned to normal after the exposure. Dr. Carlsten speculated that the effects could be long lasting where exposure is continuous. He said that people should be mindful of the air they're breathing and take appropriate steps to minimize their exposure to potentially harmful air pollutants like car exhaust.

"People may want to think twice the next time they're stuck in traffic with the windows rolled down," said Dr. Carlsten. "It's important to ensure that your car's air filter is in good working order, and if you're walking or biking down a busy street, consider diverting to a less busy route."

While the current study only looked at the cognitive impacts of traffic-derived pollution, Dr. Carlsten said that other products of combustion are likely a concern.

"Air pollution is now recognized as the largest environmental threat to human health and we are increasingly seeing the impacts across all major organ systems," says Dr. Carlsten. "I expect we would see similar impacts on the brain from exposure to other air pollutants, like forest fire smoke. With the increasing incidence of neurocognitive disorders, it's an important consideration for public health officials and policymakers."

The study was conducted at UBC's Air Pollution Exposure Laboratory, located at Vancouver General Hospital, which is equipped with a state-of-the-art exposure booth that can mimic what it is like to breathe a variety of air pollutants. In this study, which was carefully designed and approved for safety, the researchers used freshly-generated exhaust that was diluted and aged to reflect real-world conditions.

https://www.sciencedaily.com/releases/2023/01/230124112731.htm

New research quantifies the 'wow' factor of sunrise and sunset

January 19, 2023

Science Daily/University of Exeter

A new study has identified the impact that fleeting natural events, such as sunrises and sunsets, can have on people, and sought to quantify their effects for the first time.

Despite a large body of research examining the impacts of nature on our mental health, most studies have assessed these effects under calm, blue skies. Surprisingly few have considered how we respond to variations in weather and the daily rhythms of the sun, changes referred to as 'ephemeral phenomena'.

To help close this gap, researchers used the latest computer graphics to show carefully controlled images of both urban and natural environments to more than 2,500 participants. When these scenes featured elements such as sunrise and sunset, participants considered them to be substantially more beautiful than when seen under sunny conditions at any other time of day.

Unexpectedly, the paper revealed that sunrise and sunset could also trigger significant boosts in people's feelings of awe. A typically difficult emotion to elicit, research indicates that awe has the potential to improve mood, enhance positive social behaviour, and increase positive emotions -- all valuable factors in enhancing overall wellbeing.

Published in the Journal of Environmental Psychology, the paper also considered rarer events, such as rainbows, thunderstorms, and starry, moonlit skies in the experiment. Each of these phenomena altered the extent to which people experienced beauty and awe in different landscapes, when compared to sunny, blue skies.

Crucially, these changes were also behind variations in how the environments were valued -- assessed by asking participants how much they would be willing to pay to experience each scene in the real world.

Participants were prepared to pay a premium of almost 10 per cent to visit a natural setting at sunrise compared to under blue skies. The research team said this kind of added value is normally attributed to more permanent features, such as scenic lakes or historic buildings. They suggested that encouraging people to experience sunsets and sunrises could help boost wellbeing, and might be used as part of green prescribing, where nature plays a therapeutic role in mental health treatment.

Alex Smalley, PhD fellow at the University of Exeter and lead author of the research, said: "We're all familiar with the urge to take a photo of a brilliant sunset or unexpected rainbow. The term 'sunset' has over 300 million tags on Instagram and people told us they'd be willing to pay a premium to experience these phenomena, but of course we can all experience them for free. Our research indicates that getting up a bit earlier for sunrise or timing a walk to catch sunset could be well worth the effort -- the 'wow' factor associated with these encounters might unlock small but significant bumps in feelings of beauty and awe, which could in turn have positive impacts for mental wellbeing."

The authors also noted how the occurrence of the phenomena they tested could vary greatly based on where people live. Those on east-facing coastlines might find sunrise easier to see, whilst those in the west might more frequently experience sunset. Equally, thunderstorms may be more common in summer in the UK, yet rainbows appear more often in winter. Alex Smalley added: "Most of the phenomena we tested can be fleeting and unpredictable, and we think this novelty is partly behind the effects we're seeing. Given their potential to change people's experiences in both natural and urban landscapes, there could be real value in highlighting how and where these events might be experienced, particularly in towns and cities."

https://www.sciencedaily.com/releases/2023/01/230119112753.htm

In the wake of a wildfire, embers of change in cognition and brain function linger

People exposed to the deadly Camp Fire in 2018 displayed altered cognitive function months later; it's new evidence of a growing phenomenon known as 'climate trauma'

January 18, 2023

Science Daily/University of California - San Diego

n November 2018, the Camp Fire burned a total of 239 square miles, destroyed 18,804 structures and killed 85 people, making it the deadliest and most destructive wildfire in California history.

Three years later, researchers at University of California San Diego, published a novel study that looked at the psychological consequences, finding that exposure to "climate trauma" for affected residents resulted in increased and chronic mental health problems, such as post-traumatic stress disorder and depression.

In a new study, published in the January 18, 2023 online issue of PLOS Climate, senior author Jyoti Mishra, PhD, associate professor in the Department of Psychiatry at UC San Diego School of Medicine, director of the Neural Engineering and Translation Labs at UC San Diego, and associate director of the UC Climate and Mental Health Initiative, delved deeper with her colleagues. The study team reported that in a subset of persons exposed to the Camp Fire, significant differences in cognitive functioning and underlying brain activity were revealed using electroencephalography (EEG).

Specifically, the researchers found that fire-exposed individuals displayed increased activity in the regions of the brain involved in cognitive control and interference processing -- the ability to mentally cope with unwanted and often disturbing thoughts.

"To function well day-to-day, our brains need to process information and manage memories in ways that help achieve goals while ignoring or dispensing with irrelevant or harmful distractions," said Mishra.

"Climate change is an emerging challenge. It is already well-documented that extreme climate events result in significant psychological impacts. Warming temperatures, for example, have even been linked to greater suicide rates. As planetary warming amplifies, more forest fires are expected in California and globally, with significant implications for mental health effects.

"In this study, we wanted to learn whether and how climate trauma affected and altered cognitive and brain functions in a group of people who had experienced it during the Camp Fire. We found that those who were impacted, directly or indirectly, displayed weaker interference processing. Such weakened cognitive performance may then impair daily functioning and reduce wellbeing."

The study sample included 27 persons directly exposed to the Camp Fire (for example, their homes were destroyed), 21 who were indirectly exposed (they witnessed the fire, but were not directly impacted) and 27 control individuals. All participants underwent cognitive testing with synchronized EEG brain recordings.

Sixty-seven percent of the individuals directly exposed to the fire reported having experienced recent psychological trauma, as did 14 percent of the indirectly exposed individuals. None of the control individuals reported recent trauma exposure.

The EEG recordings showed that the brains of those individuals reporting trauma worked harder at interference processing and cognitive control, suggesting a compensatory effort but at a cost: potentially heightened risk of neurological dysfunction elsewhere.

"The evidence of diminished interference processing, along with altered functional brain responses, is useful because it can help guide efforts to develop resiliency intervention strategies," said Mishra.

"As the planet warms, more and more individuals will face extreme climate exposures, like wildfires, and having therapeutic tools that can address underlying neuro-cognitive issues will be an important complement to other socio-behavioral therapies."

https://www.sciencedaily.com/releases/2023/01/230118195708.htm

Vitamin D benefits and metabolism may depend on body weight

People with higher body mass index had a blunted response to vitamin D supplementation, explaining observed differences in outcomes such as cancer, diabetes, and autoimmune disease

January 17, 2023

Science Daily/Brigham and Women's Hospital

Researchers from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, have found new evidence that vitamin D may be metabolized differently in people with an elevated body mass index (BMI). The study, appearing in JAMA Network Open, is a new analysis of data from the VITAL trial, a large nationwide clinical trial led by Brigham researchers that investigated whether taking vitamin D or marine omega-3 supplements could reduce the risk of developing cancer, heart disease, or stroke.

"The analysis of the original VITAL data found that vitamin D supplementation correlated with positive effects on several health outcomes, but only among people with a BMI under 25," said first author Deirdre K. Tobias, ScD, an associate epidemiologist in Brigham's Division of Preventive Medicine. "There seems to be something different happening with vitamin D metabolism at higher body weights, and this study may help explain diminished outcomes of supplementation for individuals with an elevated BMI."

Vitamin D is an essential nutrient involved in many biological processes, most notably helping our body absorb minerals, such as calcium and magnesium. While some of the vitamin D we need is made in the body from sunlight, vitamin D deficiencies are often treated with supplementation. Evidence from laboratory studies, epidemiologic research and clinical research has also suggested that vitamin D may play a role in the incidence and progression of cancer and cardiovascular disease, and it was this evidence that prompted the original VITAL trial.

The VITAL trial was a randomized, double-blind, placebo-controlled trial in 25,871 U.S. participants, which included men over the age of 50 and women over the age of 55. All participants were free of cancer and cardiovascular disease at the time of enrollment. While the trial found little benefit of vitamin D supplementation for preventing cancer, heart attack, or stroke in the overall cohort, there was a statistical correlation between BMI and cancer incidence, cancer mortality, and autoimmune disease incidence. Other studies suggest similar results for type 2 diabetes.

The new study aimed to investigate this correlation. The researchers analyzed data from 16,515 participants from the original trial who provided blood samples at baseline (before randomization to vitamin D), as well as 2,742 with a follow-up blood sample taken after two years. The researchers measured the levels of total and free vitamin D, as well as many other novel biomarkers for vitamin D, such as its metabolites, calcium, and parathyroid hormone, which helps the body utilize vitamin D.

"Most studies like this focus on the total vitamin D blood level," said senior author JoAnn E. Manson, MD, DrPH, chief of the Division of Preventive Medicine at the Brigham and principal investigator of VITAL. "The fact that we were able to look at this expanded profile of vitamin D metabolites and novel biomarkers gave us unique insights into vitamin D availability and activity, and whether vitamin D metabolism might be disrupted in some people but not in others."

The researchers found that vitamin D supplementation increased most of the biomarkers associated with vitamin D metabolism in people, regardless of their weight. However, these increases were significantly smaller in people with elevated BMIs.

"We observed striking differences after two years, indicating a blunted response to vitamin D supplementation with higher BMI," Tobias said. "This may have implications clinically and potentially explain some of the observed differences in the effectiveness of vitamin D supplementation by obesity status."

"This study sheds light on why we're seeing 30-40 percent reductions in cancer deaths, autoimmune diseases, and other outcomes with vitamin D supplementation among those with lower BMIs but minimal benefit in those with higher BMIs, suggesting it may be possible to achieve benefits across the population with more personalized dosing of vitamin D," said Manson. "These nuances make it clear that there's more to the vitamin D story."

The authors conclude that the VITAL findings are a call to action for the research community to continue exploring the potential benefits of vitamin D supplementation for preventing cancer and other diseases and to take BMI into account when evaluating the supplement's health impacts.

https://www.sciencedaily.com/releases/2023/01/230117110511.htm

Support from others in stressful times can ease impact of genetic depression risk

Study in first-year doctors and recently widowed older adults shows greatest impact of social support in those with highest polygenic risk scores for depression

January 13, 2023

Science Daily/Michigan Medicine - University of Michigan

Reaching out to support a person when they're under stress is always a good idea. But a new study suggests that support could be especially important for someone whose genetic makeup makes them more likely to develop depression.

The study shows the importance of social support in buffering the risk of developing depression symptoms in general, using data from two very different groups of people under stress: new doctors in the most intense year of training, and older adults whose spouses recently died.

But the largest effect was seen in those who had the most genetic variation that raised the risk of depression.

The paper uses a measure of genetic risk called a polygenic risk score, which is based on decades of research about what tiny variations in specific genes are linked to depression risk.

Compared to individuals in the study who had low depression polygenic risk scores, the doctors and widows with higher risk scores had higher rates of depression after they lost social support, but also had lower rates of depression when they gained social support during stressful times.

The study, published in the American Journal of Psychiatry by a University of Michigan team, suggests that more could be done to target social support to those who can most benefit.

Genes, stress and social connection

"Our data show wide variability in the level of social support individuals received during these stressful times, and how it changed over time," said first author Jennifer Cleary, M.S., a psychology doctoral student at U-M who is doing her research with senior author Srijan Sen, M.D., Ph.D., of the U-M Medical School. "We hope these findings, which incorporate genetic risk scores as well as measures of social support and depressive symptoms, illuminate the gene-environment interactions and specifically the importance of social connection in depression risk."

Sen, who is the director of the Eisenberg Family Depression Center and a professor of psychiatry and neuroscience, adds that even as genetic research reveals more of the DNA variation related to depression vulnerability, learning how that variation leads to depression is crucial.

"Further understanding the different genetic profiles associated with sensitivity to loss of social support, insufficient sleep, excessive work stress and other risk factors could help us develop personalized guidance for depression prevention," he said. "In the meantime, these findings reaffirm how important social connections, social support and individual sensitivity to the social environment are as factors in wellbeing and preventing depression."

Different populations, similar patterns

The new study used data from two long-term studies that both capture genetic, mood, environment and other data from populations of participating individuals.

One is the Intern Health Study, which enrolls first-year medical residents (also called interns) around the United States and beyond, and which Sen directs.

The other is the Health and Retirement Study, based at the U-M Institute for Social Research and funded by the National Institute on Aging.

The data for the new paper came from 1,011 interns training at hospitals across the country, nearly half of whom were female, and from 435 recently widowed individuals, 71% of them women, who had data available from surveys conducted before and after their spouses died.

In the interns, as Sen and his team have shown in previous work, depressive symptoms increased dramatically (126%) during the stressful year of training that includes long and irregular work hours -- often in environments far from friends and family.

In the widows and widowers, depressive symptoms increased 34% over their pre-widowhood scores. This correlates with past research showing loss of a spouse can be one of the biggest stressors in a person's life, Cleary said.

A crossover effect

Then, the researchers factored together the depression symptom findings with each person's polygenic risk score for depression, and their individual responses to questions about connections with friends, family and other social supporters.

Most of the interns lost social support from their pre-internship days -- which fits well with the common experience of leaving the place where they attended medical school and going to a new environment where they may not know anyone.

Interns who had the highest polygenic risk scores and also lost social support had the highest scores on measures of depression symptoms later in the stressful intern year.

Those with the same high level of genetic risk who gained social support, though, had much lower depressive symptoms. In fact, it was lower than even their peers with low genetic risk, no matter what happened to their social support. The researchers call this a "crossover effect."

Unlike the interns, some widowed individuals reported an increase in social support after the loss of their spouse, potentially as friends and family reached out to offer help or just a listening ear.

But the crossover effect was visible in them, too. Widows with high genetic risk for depression who gained social support showed a much smaller increase in depressive symptoms than their peers with similar genetic risk who lost social support after losing a spouse.

There were also some widows who lost social support or didn't experience a change in support, and whose depressive symptoms didn't change. Cleary notes that in future work, it will be important to look at this group's history in light of any caregiving they may have done for a spouse with a long-term illness.

The team also hopes that other researchers will study this same interaction of genetic risk, stress and social support in other populations.

In the meantime, Cleary and Sen say, the message for anyone going through stressful times, or watching a friend or relative go through stressful times, is to reach out and maintain or strengthen social connections.

Doing so can have benefits both for the person under stress, and the person reaching out to them, they note.

Reducing the level of ongoing stress that the person is facing, whether it's at work, school, after a personal loss or in family situations can be critical.

And even though the study did not examine the role of professional mental health help, individual and group therapy is an important option for those who have developed depression or other mental health concerns.

Note: The polygenic risk score used in the study is validated for use on people of mainly European ancestry, which limits the ability to generalize the findings to people of other backgrounds. Sen notes that additional work is being done using data from the Intern Health Study and Health & Retirement Study to develop polygenic risk scores based on depression-related genetic traits in other populations including people of East Asian and African descent.

https://www.sciencedaily.com/releases/2023/01/230113112733.htm

Feeling loved, optimistic or happy as a teen may lead to better health in adulthood

January 11, 2023

Science Daily/American Heart Association

Teenagers who reported feeling optimism, happiness, self-esteem, belongingness, and feeling loved and wanted were more likely to reach their 20s and 30s in good cardiometabolic health compared to teens with fewer of these positive mental health assets, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

Previous studies have found that psychological facets of mental well-being, such as optimism and happiness, may be important modifiable factors related to better cardiometabolic health over time. While most of this research was conducted among older adults, this study focused earlier in life and considered a broader measure of cardiometabolic health, which also included indicators of blood sugar levels and inflammation.

"We learned a lot in the last few decades about the impact of discrimination and other social risks youth of color face that may explain their elevated rates of cardiometabolic disease, however, much less attention is paid to the inherent strengths they possess and the ways those strengths may be leveraged to advance health equity," said lead study author Farah Qureshi, Sc.D., M.H.S., an assistant professor at the Johns Hopkins Bloomberg School of Public Health in Baltimore. "In this study, we wanted to shift the paradigm in public health beyond the traditional focus on deficits to one that concentrates on resource building."

Researchers examined data from the National Longitudinal Study of Adolescent Health, which enrolled nearly 3,500 U.S. high schoolers (average age 16 years) in 1994 and were followed for more than two decades. Nearly half were girls, 67% were white youth, 15% were Black teens, 11% were Latino teenagers and 6% reported their race as either Native American, Asian, or "other." Researchers periodically collected data on the participants' health and well-being, with the most recent wave of data collection occurring in 2018, when their average age was 38.

Using initial survey responses from when participants were teenagers, researchers identified five mental health assets related to better cardiometabolic health outcomes: optimism, happiness, self-esteem, a sense of belonging and feeling loved. This information was cross-referenced with health data recorded over 3 decades to assess whether teens who had more of these positive assets were more likely to maintain optimal cardiometabolic health in adulthood.

To examine cardiometabolic health in this study, researchers reviewed health measures for seven cardiovascular and metabolic disease risk factors collected during clinic visits when participants were in their late 20s and 30s. The factors included high-density lipoprotein (HDL), or "good" cholesterol; non-HDL cholesterol -- calculated as total cholesterol minus HDL cholesterol; systolic blood pressure (top number); diastolic blood pressure (bottom number); hemoglobin A1c, a measure of blood sugar; C-reactive protein, a measure of inflammation; and body mass index, or BMI, the ratio of height to weight to estimate body fat.

The analysis found:

• Overall, 55% of youth had zero to one positive mental health asset, while 29% had two to three assets and 16% had four to five assets.

• As young adults, only 12% of participants maintained cardiometabolic health over time, and white youth were more likely to maintain good health later in life compared to Black or Latino youth.

• Teens with four to five positive mental health assets were 69% more likely to maintain positive cardiometabolic health as young adults.

• There was also a cumulative effect, with each additional mental health asset conferring a 12% greater likelihood of positive cardiometabolic health.

• Although psychological assets were found to be protective across all racial and ethnic groups, the largest health benefits were noted among Black youth. Black teens also reported having more positive mental health assets than youth of any other racial or ethnic groups.

Despite Black teens having the most assets and deriving the most health benefits from them, racial disparities in cardiometabolic health were still apparent in adulthood. Black individuals were the least likely to maintain good cardiometabolic health over time.

"These somewhat counterintuitive findings were surprising," Qureshi said. "When we dug deeper, we found that the absence of psychological assets being was particularly health-damaging for Black youth." She further elaborated that the findings point to the role structural racism plays in shaping cardiometabolic health patterns in the first decades of life: "For Black youth -- who face numerous barriers to achieving and sustaining optimal cardiometabolic health in adulthood -- not having these additional mental health resources makes a big difference."

"This work suggests that early investments in youth mental health may be a critical new frontier in the advancement of cardiometabolic health equity," according to Qureshi.

"We need more large-scale studies to monitor these and other positive mental health factors starting in childhood to understand how these assets may influence health and disease over the life course. This information may help us identify new ways to improve health and reduce disparities," she said.

Limitations of the study include that there were relatively few participants who were Latino, Asian or Native American and there were variations in blood sample collection methods over time.

Health care professionals measure cardiovascular health with the American Heart Association's Life's Essential 8 tool, which measures 4 indicators related to cardiovascular and metabolic health status (blood pressure, cholesterol, blood sugar and body mass index); and 4 behavioral/lifestyle factors (smoking status, physical activity, sleep and diet). According to Life's Essential 8 data:

• only 45% of U.S. adolescents have five or more indicators of ideal cardiovascular health, and the percentage declines in adulthood; and

• there are persistent differences in cardiovascular health levels by self-reported race and ethnicity, and these disparities are larger at younger ages.

https://www.sciencedaily.com/releases/2023/01/230111075843.htm

An education doesn't just make you smarter -- it protects your gut, seriously

January 11, 2023

Science Daily/Edith Cowan University

We've long known education is important for many aspects of life, but now a new benefit has been discovered: it can look after your gut health.

Landmark Edith Cowan University (ECU) research has found a better education has a strong genetic correlation and a protective causal association with several gut disorders.

A previous study from ECU's Centre for Precision Health (CPH) discovered a genetic link between gut health and Alzheimer's Disease (AD) but couldn't conclude whether one caused the other.

This study breaks new ground by finding that a higher level of education protects against gut disorders.

CPH Director and study supervisor Professor Simon Laws said these findings build upon the centre's previous work to provide further evidence of the strong links between the brain and gut, known as the gut-brain axis.

"Gut disorders and Alzheimer's may not only share a common genetic predisposition but may be similarly influenced by genetic variations underpinning educational attainment," Professor Laws said.

This large-scale study examined the genetic information of more than 766,000 individuals, with an emphasis on AD, cognitive traits and gut disorders, including peptic ulcer disease (PUD), gastritis-duodenitis, gastroesophageal reflux disease (GERD), irritable bowel syndrome, diverticulosis and inflammatory bowel disease (IBD).

It found higher levels of education and cognitive functioning reduced the risk of gut disorders.

Lead researcher Dr Emmanuel Adewuyi said the findings have significant implications.

"The results support education as a possible avenue for reducing the risk of gut disorders

by, for example, encouraging higher educational attainment or a possible increase in the length of schooling," he said.

"Hence, policy efforts aimed at increasing educational attainment or cognitive training may contribute to a higher level of intelligence, which could lead to better health outcomes including a reduced risk of gut disorders."

It goes both ways

ECU's study further revealed the gut may also influence the brain.

GERD showed evidence of causing a decline in cognitive function across a number of cognitive traits assessed in the study, such as intelligence, cognitive performance, educational attainment and educational qualification.

Although this is the first study to report this finding, the results support recent research reporting an increased incidence of dementia and GERD, which Dr Adewuyi said could help with earlier diagnoses and potential treatments.

"GERD may be a risk factor for cognitive impairment, so it's important for health workers to look for signs or symptoms of cognitive dysfunction in patients presenting with the gut disorder," he said.

"This could lead to earlier detection of cognitive decline and therefore earlier interventions aimed at reducing the rate of cognitive decline.

"More studies are needed to investigate whether treatment for, cure or remission of GERD can contribute to a reduced risk of cognitive decline."

The curious case of IBD

Interestingly, higher levels of education and cognitive function protecting against gut disorders was true of all the disorders examined in the study -- but largely with the exception of inflammatory bowel disease.

Further analysis reveals different effects of IBD on cognitive traits and AD at different genomic locations, indicating its relationship depend on effects at specific locations across the genome.

This new understanding may explain the lack of significant genetic correlation of IBD with cognitive traits and AD, and the inconsistency reported in previous observational studies.

Dr Adewuyi said this finding was also important, as it brings a new insight into the relationship of IBD with cognitive traits (and AD), which may shape the direction of future studies.

"For example, some risk genes for AD may be protective against IBD, and vice versa," he said.

'Relationship of cognition and Alzheimer's disease with gastrointestinal tract disorders: a large-scale genetic overlap and Mendelian randomisation analysis' was published in the International Journal of Molecular Sciences.

https://www.sciencedaily.com/releases/2023/01/230111075855.htm

Feeling depressed? Performing acts of kindness may help

Study finds helping others reduces focus on your own symptoms

January 10, 2023

Science Daily/Ohio State University

People suffering from symptoms of depression or anxiety may help heal themselves by doing good deeds for others, new research shows.

The study found that performing acts of kindness led to improvements not seen in two other therapeutic techniques used to treat depression or anxiety.

Most importantly, the acts of kindness technique was the only intervention tested that helped people feel more connected to others, said study co-author David Cregg, who led the work as part of his PhD dissertation in psychology at The Ohio State University.

"Social connection is one of the ingredients of life most strongly associated with well-being. Performing acts of kindness seems to be one of the best ways to promote those connections," Cregg said.

Cregg conducted the research with Jennifer Cheavens, professor of psychology at Ohio State. Their study was published recently in The Journal of Positive Psychology.

The research also revealed why performing acts of kindness worked so well: It helped people take their minds off their own depression and anxiety symptoms.

This finding suggests that one intuition many people have about people with depression may be wrong, Cheavens said.

"We often think that people with depression have enough to deal with, so we don't want to burden them by asking them to help others. But these results run counter to that," she said.

"Doing nice things for people and focusing on the needs of others may actually help people with depression and anxiety feel better about themselves."

The study involved 122 people in central Ohio who had moderate to severe symptoms of depression, anxiety, and stress.

After an introductory session, the participants were split into three groups. Two of the groups were assigned to techniques often used in cognitive behavioral therapy (CBT) for depression: planning social activities or cognitive reappraisal.

The social activities group was instructed to plan social activities for two days a week. Another group was instructed in one of the staples of CBT: cognitive reappraisal. These participants kept records for at least two days each week that helped them identify negative thought patterns and revise their thoughts in a way that could reduce depression and anxiety.

Members of the third group were instructed to perform three acts of kindness a day for two days out of the week. Acts of kindness were defined as "big or small acts that benefit others or make others happy, typically at some cost to you in terms of time or resources."

Some of the acts of kindness that participants later said they did included baking cookies for friends, offering to give a friend a ride, and leaving sticky notes for roommates with words of encouragement.

Participants followed their instructions for five weeks, after which they were evaluated again. The researchers then checked with the participants after another five weeks to see if the interventions were still effective.

The findings showed that participants in all three groups showed an increase in life satisfaction and a reduction of depression and anxiety symptoms after the 10 weeks of the study.

"These results are encouraging because they suggest that all three study interventions are effective at reducing distress and improving satisfaction," Cregg said.

"But acts of kindness still showed an advantage over both social activities and cognitive reappraisal by making people feel more connected to other people, which is an important part of well-being," he said.

In addition, the acts of kindness group showed greater improvements than the cognitive reappraisal group for life satisfaction and symptoms of depression and anxiety, results showed.

Cheavens noted that just participating in social activities did not improve feelings of social connection in this study.

"There's something specific about performing acts of kindness that makes people feel connected to others. It's not enough to just be around other people, participating in social activities," she said.

Cregg said that while this study used techniques of CBT, it is not the same experience as going through CBT. Those who undergo the full treatment may have better results than those in this study.

But the findings also show that even the limited CBT exposure given in this study can be helpful, Cheavens said.

"Not everyone who could benefit from psychotherapy has the opportunity to get that treatment," she said. "But we found that a relatively simple, one-time training had real effects on reducing depression and anxiety symptoms."

And beyond traditional CBT, acts of kindness may have additional benefits in creating social connections, Cregg said.

"Something as simple as helping other people can go above and beyond other treatments in helping heal people with depression and anxiety," he said.

https://www.sciencedaily.com/releases/2023/01/230110103424.htm

Gardening may help reduce cancer risk, boost mental health

January 6, 2023

Science Daily/University of Colorado at Boulder

Get more exercise. Eat right. Make new friends.

As we compile our lists of resolutions aimed at improving physical and mental health in 2023, new CU Boulder research suggests one addition could have a powerful impact: Gardening.

Funded by the American Cancer Society, the first-ever, randomized, controlled trial of community gardening found that those who started gardening ate more fiber and got more physical activity -- two known ways to reduce risk of cancer and chronic diseases. They also saw their levels of stress and anxiety significantly decrease.

The findings were published Jan. 4 in the journal Lancet Planetary Health.

"These findings provide concrete evidence that community gardening could play an important role in preventing cancer, chronic diseases and mental health disorders," said senior author Jill Litt, a professor in the Department of Environmental Studies at CU Boulder.

Filling the research gap

Litt has spent much of her career seeking to identify affordable, scalable and sustainable ways to reduce disease risk, especially among low-income communities.

Gardening seemed an ideal place to start.

"No matter where you go, people say there's just something about gardening that makes them feel better," said Litt, who is also a researcher with the Barcelona Institute for Global Health.

But solid science on its benefits is hard to come by. Without evidence, it's hard to get support for new programs, she said.

Some small observational studies have found that people who garden tend to eat more fruits and vegetables and have a healthier weight. But it has been unclear whether healthier people just tend to garden, or gardening influences health.

Only three studies have applied the gold standard of scientific research, the randomized controlled trial, to the pastime. None have looked specifically at community gardening.

To fill the gap, Litt recruited 291 non-gardening adults, average age of 41, from the Denver area. More than a third were Hispanic and more than half came from low-income households.

After the last spring frost, half were assigned to the community gardening group and half to a control group that was asked to wait one year to start gardening.

The gardening group received a free community garden plot, some seeds and seedlings, and an introductory gardening course through the nonprofit Denver Urban Gardens program and a study partner.

Both groups took periodic surveys about their nutritional intake and mental health, underwent body measurements and wore activity monitors.

A fiber boost

By fall, those in the gardening group were eating, on average, 1.4 grams more fiber per day than the control group -- an increase of about 7%.

The authors note that fiber exerts a profound effect on inflammatory and immune responses, influencing everything from how we metabolize food to how healthy our gut microbiome is to how susceptible we are to diabetes and certain cancers.

While doctors recommend about 25 to 38 grams of fiber per day, the average adult consumes less than 16 grams.

"An increase of one gram of fiber can have large, positive effects on health," said co-author James Hebert, director of University of South Carolina's cancer prevention and control program.

The gardening group also increased their physical activity levels by about 42 minutes per week. Public health agencies recommend at least 150 minutes of physical activity per week, a recommendation only a quarter of the U.S. population meets. With just two to three visits to the community garden weekly, participants met 28% of that requirement.

Study participants also saw their stress and anxiety levels decrease, with those who came into the study most stressed and anxious seeing the greatest reduction in mental health issues.

The study also confirmed that even novice gardeners can reap measurable health benefits of the pastime in their first season. As they have more experience and enjoy greater yields, Litt suspects such benefits will increase.

Blooming relationships

The study results don't surprise Linda Appel Lipsius, executive director of Denver Urban Gardens (DUG), a 43-year-old nonprofit that helps about 18,000 people each year grow their own food in community garden plots.

"It's transformational, even life-saving, for so many people," Lipsius said.

Many DUG participants live in areas where access to affordable fresh fruits and vegetables is otherwise extremely limited. Some are low-income immigrants now living in apartments -- having a garden plot allows them to grow food from their home country and pass on traditional recipes to their family and neighbors.

The social connection is also huge.

"Even if you come to the garden looking to grow your food on your own in a quiet place, you start to look at your neighbor's plot and share techniques and recipes, and over time relationships bloom," said Litt, noting that while gardening alone is good for you, gardening in community may have additional benefits. "It's not just about the fruits and vegetables. It's also about being in a natural space outdoors together with others."

Litt said she hopes the findings will encourage health professionals, policymakers and land planners to look to community gardens, and other spaces that encourage people to come together in nature, as a vital part of the public health system. The evidence is clear, she said.

https://www.sciencedaily.com/releases/2023/01/230106144500.htm

People sleep the least from early 30s to early 50s

December 23, 2022

Science Daily/University College London

People sleep less in mid-adulthood than they do in early and late adulthood, finds a new study led by UCL, University of East Anglia and University of Lyon researchers.

Sleep duration declines in early adulthood until age 33, and then picks up again at age 53, according to the findings published in Nature Communications.

The study, involving 730,187 participants spread over 63 countries, revealed how sleep patterns change across the lifespan, and how they differ between countries.

Study participants were playing the Sea Hero Quest mobile game, a citizen science venture designed for neuroscience research, created by Deutsche Telekom in partnership with Alzheimer's Research UK, UCL, UEA and game developers Glitchers. Designed to aid Alzheimer's research by shedding light on differences in spatial navigational abilities, over four million people have played Sea Hero Quest, contributing to numerous studies across the project as a whole.

In addition to completing tasks testing navigational ability, anyone playing the game is asked to answer questions about demographic characteristics as well as other questions that can be useful to neuroscience research, such as on sleep patterns.

The researchers, led by Professor Hugo Spiers (UCL Psychology & Language Sciences) and Dr Antoine Coutrot (CNRS, University of Lyon) found that across the study sample, people sleep an average of 7.01 hours per night, with women sleeping 7.5 minutes longer than men on average. They found that the youngest participants in the sample (minimum age 19) slept the most, and sleep duration declined throughout people's 20s and early 30s before plateauing until their early 50s and increasing again. The pattern, including the newly-identified key time points of age 33 when declining sleep plateaus and 53 for sleep to increase again, was the same for men and women, and across countries and education levels.

The researchers say the decline in sleep during mid-life may be due to demands of childcare and working life.

Professor Spiers said: "Previous studies have found associations between age and sleep duration, but ours is the first large study to identify these three distinct phases across the life course. We found that across the globe, people sleep less during mid-adulthood, but average sleep duration varies between regions and between countries."

People who report sleeping the most are in Eastern European countries such as Albania, Slovakia, Romania and the Czech Republic, reporting 20-40 minutes extra sleep per night and the least in South East Asian countries including the Philippines, Malaysia and Indonesia. People in the United Kingdom reported sleeping slightly less than the average. People tended to sleep a bit less in countries closer to the equator.

The researchers found that navigational ability was unaffected by sleep duration for most of the sample, except for among older adults (aged 54-70) whose optimal sleep duration was seven hours, although they caution that the findings among older adults might be impacted by underlying health conditions.

https://www.sciencedaily.com/releases/2022/12/221223103424.htm