For older adults, every 500 additional steps taken daily associated with lower heart risk

American Heart Association Epidemiology, Prevention, Lifestyle & Cardiometabolic Health Scientific Sessions 2023, Presentation 360

March 3, 2023

Science Daily/American Heart Association

A new study found that walking an additional 500 steps, or about one-quarter of a mile, per day was associated with a 14% lower risk of heart disease, stroke or heart failure, according to preliminary research to be presented at the American Heart Association's Epidemiology, Prevention, Lifestyle & Cardiometabolic Health Scientific Sessions 2023. The meeting will be held in Boston, February 28-March 3, 2023, and offers the latest science on population-based health and wellness and implications for lifestyle and cardiometabolic health.

"Steps are an easy way to measure physical activity, and more daily steps were associated with a lower risk of having a cardiovascular disease-related event in older adults," said Erin E. Dooley, Ph.D., an assistant professor of epidemiology at the University of Alabama at Birmingham School of Public Health and lead researcher of the study. "However, most studies have focused on early-to-midlife adults with daily goals of 10,000 or more steps, which may not be attainable for older individuals."

Participants in the current analysis were part of a larger study group of 15,792 adults originally recruited for the ongoing Atherosclerosis Risk in Communities (ARIC) study. The present study evaluated health data collected from ARIC study visit 6 (2016-17) to evaluate the potential association between daily step counts and cardiovascular disease.

Researchers analyzed health data for 452 participants who used an accelerometer device similar to a pedometer, worn at the hip, that measured their daily steps. Participants were an average age of 78 years old; 59% were women; and 20% of participants self-identified as Black adults (70% of whom were women, and 30% of whom were men).

The devices were worn for three or more days, for ten or more hours, and the average step count was about 3,500 steps per day. Over the 3.5-year follow-up period, 7.5% of the participants experienced a cardiovascular disease event, such as coronary heart disease, stroke or heart failure.

The analysis found:

• Compared to adults who took less than 2,000 steps per day, adults who took approximately 4,500 steps per day had a 77% lower observed risk of experiencing a cardiovascular event.

• Nearly 12% of older adults with less than 2,000 steps per day had a cardiovascular event, compared to 3.5% of the participants who walked about 4,500 steps per day.

• Every additional 500 steps taken per day was incrementally associated with a 14% lower risk of cardiovascular disease.

"It's important to maintain physical activity as we age, however, daily step goals should also be attainable. We were surprised to find that every additional quarter of a mile, or 500 steps, of walking had such a strong benefit to heart health," Dooley said. "While we do not want to diminish the importance of higher intensity physical activity, encouraging small increases in the number of daily steps also has significant cardiovascular benefits. If you are an older adult over the age of 70, start with trying to get 500 more steps per day."

Additional research is needed to determine if meeting a higher daily count of steps prevents or delays cardiovascular disease, or if lower step counts may be an indicator of underlying disease.

Everyone can improve their cardiovascular health by following the American Heart Association's Life's Essential 8: eating healthy food, being physically active, not smoking, getting enough sleep, maintaining a healthy weight, and controlling cholesterol, blood sugar and blood pressure levels. Cardiovascular disease claims more lives each year in the U.S. than all forms of cancer and chronic lower respiratory disease combined, according to the American Heart Association.

The study had limitations. Participants had to enroll in the accelerometer device study, and hip-worn accelerometers are limited in capturing other activity behaviors that may also be important to heart health, such as bicycling and swimming. Study participants were more likely to have had at least some college or above education compared to the overall ARIC sample, and primarily self-identified as white and female, which may limit the study's generalizability. Additionally, steps were only measured at one single point in time, and the researchers were unable to examine if changes in steps over time impacted CVD event risk.

https://www.sciencedaily.com/releases/2023/03/230303105410.htm

Brain stimulation improves motor skill learning at older age

July 27, 2022

Science Daily/Ecole Polytechnique Fédérale de Lausanne

Even though we don't think about it, every movement we make in our daily life essentially consists of a sequence of smaller actions in a specific order. The only time we realize this is when we have to learn a new motor skill, like a sport, a musical instrument, a new dance routine or even a new electronic device such as a smart phone or videogame controller.

Perhaps unsurprisingly, there is a lot of research invested in figuring out how humans acquire sequential motor skills, with a majority of studies in healthy young adults. Studies involving older individuals (and common experience) show that the older we get, the harder it is and the longer it takes to learn new motor skills, suggesting an age-related decrease in learning ability.

"As learning is crucial for continuously adapting and staying integrated in daily life, improving these impaired functions will help to maintain the quality of life as we age, especially in view of the constant increase in life expectancy seen worldwide," says Professor Friedhelm Hummel who holds the Defitech Chair of Clinical Neuroengineering at EPFL's School of Life Sciences.

In a new study, Hummel and his PhD student Pablo Maceira-Elvira have found that transcranial brain stimulation can improve the age-related impairment in learning new motor skills.

The study used a common way of evaluating how well a person learns new motor skills called the "finger-tapping task." It involves typing a sequence of numbers as fast and as accurately as possible. The task is popular in studies because it simulates activities that require high dexterity -- such as playing the piano or typing on a keyboard -- while providing an objective measure of "improvement," defined as a person increasing their speed without losing accuracy.

Scientists refer to this as a "shift in the speed-accuracy tradeoff," and it constitutes a key feature of learning. One of the ways the brain achieves this shift is by grouping individual motor actions into so called "motor chunks": spontaneously emerging brain structures that reduce a person's mental load, while optimizing the mechanical execution of the motor sequence. "Motor chunks emerge reliably when young adults train on the finger-tapping task, but previous studies show either lacking or deficient motor chunks in older adults," says Pablo Maceira-Elvira.

The early bird gets the motor skill

The study first trained and tested groups of younger and older adults on learning a new sequence of finger-tapping task, and revealed fundamental differences between the two. Young adults learned the finger-tapping task most efficiently by prioritizing the improvement of the accuracy during their first training session and by focusing on improving their speed thereafter. This led to a shift in the speed-accuracy tradeoff, which allowed efficient motor chunks to emerge early on.

"Older adults showed decreased fast online learning and absent offline learning," says Maceira-Elvira. "In other words, while young adults show sharp performance increases early in training and improve overnight, older adults improve at a more moderate pace and even worsen overnight." In contrast, older adults improved their accuracy gradually over the course of training, generating efficient motor chunks only after more extensive practice.

Brain stimulation improvements 

Extensive research has been carried out on novel neurotechnologies that may restore learning impairment in older people. "Recent studies have shown we can enhance motor skill acquisition by applying non-invasive brain stimulation to the motor cortex, with anodal transcranial direct current stimulation (atDCS) attracting both academic and commercial interest in recent years due to its unobtrusiveness, portability and affordability," says Hummel.

In the current study, the researchers applied atDCS to the participants and found that it helped older adults to improve their accuracy sharply earlier on in training and in a pattern similar to that seen in young adults. "Stimulation accelerated the shift in the speed-accuracy tradeoff and enabled an earlier emergence of efficient motor chunks, with 50% of older adults generating these structures during the first training session," says Maceira-Elvira.

He adds: "The study suggests that atDCS can at least partially restore motor skill acquisition in individuals with diminished learning mechanisms, by facilitating the storage of task-relevant information, quickly reducing mental load and allowing the optimization of the mechanical execution of the sequence."

"These studies add to the better understanding of age-related deficits in motor skill acquisition and offer a novel strategy to non-invasively restore these deficits," says Hummel. "These findings open novel opportunities of interventional strategies adjusted to the specific learning phase to restore deficits due to healthy aging or neurological disorder such as stroke."

https://www.sciencedaily.com/releases/2022/07/220720150625.htm

Harm from blue light exposure increases with age, research in flies suggests

July 27, 2022

Science Daily/Oregon State University

The damaging effects of daily, lifelong exposure to the blue light emanating from phones, computers and household fixtures worsen as a person ages, new research by Oregon State University suggests.

The study, published today in Nature Partner Journals Aging, involved Drosophila melanogaster, the common fruit fly, an important model organism because of the cellular and developmental mechanisms it shares with other animals and humans.

Jaga Giebultowicz, a researcher in the OSU College of Science who studies biological clocks, led a collaboration that examined the survival rate of flies kept in darkness and then moved at progressively older ages to an environment of constant blue light from light-emitting diodes, or LEDs.

The darkness-to-light transitions occurred at the ages of two, 20, 40 and 60 days, and the study involved blue light's effect on the mitochondria of the flies' cells.

Mitochondria act as a cell's power plant, generating adenosine triphosphate, or ATP, a source of chemical energy.

In earlier research, Giebultowicz showed that prolonged exposure to blue light affected flies' longevity, regardless of whether it shined in their eyes.

"The novel aspect of this new study is showing that chronic exposure to blue light can impair energy-producing pathways even in cells that are not specialized in sensing light," Giebultowicz said. "We determined that specific reactions in mitochondria were dramatically reduced by blue light, while other reactions were decreased by age independent of blue light. You can think of it as blue light exposure adding insult to injury in aging flies."

Collaborating with Giebultowicz on the work, partially funded by the National Institutes of Health, were Yujuan Song, Jun Yang and David Hendrix of the OSU College of Science, Matthew Robinson of the College of Public Health and Human Sciences, and Alexander Law and Doris Kretzschmar of Oregon Health & Science University.

The scientists note that natural light is crucial for a person's circadian rhythm -- the 24-hour cycle of physiological processes such as brain wave activity, hormone production and cell regeneration that are important factors in eating and sleeping patterns.

But there is evidence suggesting that increased exposure to artificial light is a risk factor for sleep and circadian disorders, Giebultowicz said. And with the prevalent use of LED lighting and device displays, humans are subjected to increasing amounts of light in the blue spectrum since commonly used LEDs emit a high fraction of blue light.

"This technology, LED lighting, even in most developed countries, has not been used long enough to know its effects across the human lifespan," she said. "There are increasing concerns that extended exposure to artificial light, especially blue-enriched LED light, may be detrimental to human health. While the full effects of blue light exposure across the lifespan are not yet known in humans, accelerated aging observed in short-lived model organism should alert us to the potential of cellular damage by this stressor."

In the meantime, there are a few things people can do to help themselves that don't involve sitting for hours in darkness, the researchers say. Eyeglasses with amber lenses will filter out the blue light and protect your retinas. And phones, laptops and other devices can be set to block blue emissions.

"Our previous work demonstrated that daily lifelong exposure to blue light, but not other visible wavelengths, has damaging effects on the brain, motor abilities and lifespan of the model organism," Giebultowicz said. "Now we're reporting that the damaging effects of blue light on the flies are strongly age dependent -- the same length of exposure to the same intensity of light decreases lifespan and increases neurodegeneration more significantly in old flies than in young ones."

In the earlier research, flies subjected to daily cycles of 12 hours in light and 12 hours in darkness had shorter lives compared to flies kept in total darkness or those kept in light with the blue wavelengths filtered out.

The flies exposed to blue light showed damage to their retinal cells and brain neurons and had impaired locomotion -- the flies' ability to climb the walls of their enclosures, a common behavior, was diminished.

Some of the flies in the experiment were mutants that didn't develop eyes, and even those eyeless flies displayed impairment, suggesting flies didn't have to see the light to be harmed by it.

https://www.sciencedaily.com/releases/2022/07/220727132656.htm

Ageism and health: Study shows close links

Nearly all older adults have experienced some forms of 'everyday ageism,' but those with more health concerns had higher rates

June 15, 2022

Science Daily/Michigan Medicine - University of Michigan

Nearly all older adults have experienced some form of ageism in their everyday lives, a new study finds -- whether it's seeing ageist messages and images on television or the internet, encountering people who imply that they're less capable just because they're older, or believing stereotypes about aging.

Older adults with more health concerns, though, appear most likely to have experienced this kind of "everyday ageism," according to new findings published by a team from the University of Oklahoma, Norman and the University of Michigan. The data, from a survey of more than 2,000 people between ages of 50 and 80, come from the National Poll on Healthy Aging.

The higher a person's score on a scale of everyday ageism experiences, the more likely they were to be in poor physical or mental health, to have more chronic health conditions, or to show signs of depression.

Though the study, published in JAMA Network Open, can't show cause and effect, the authors note that the linkages between ageism and health need to be explored further and taken into account when designing programs to encourage good health and well-being among older adults.

"These findings raise the question of whether aging-related health problems reflect the adverse influences of ageism and present the possibility that anti-ageism efforts could be a strategy for promoting older adult health and well-being," says first author Julie Ober Allen, Ph.D., M.P.H., Department of Health and Exercise Science, University of Oklahoma, Norman.

Allen worked on the survey during her time as a postdoctoral fellow at the Population Studies Center at U-M's Institute for Social Research.

The team previously published preliminary findings in a report from the NPHA, which is based at the U-M Institute for Healthcare Policy and Innovation and supported by AARP and Michigan Medicine, U-M's academic medical center.

But the new analysis goes further, and uses the Everyday Ageism Scale developed by the team. That scale, validated and published last year, calculates a score based on an individual's answers to 10 questions about their own experiences and beliefs regarding aging.

In all, 93% of the older adults surveyed said they regularly experienced at least one of the 10 forms of ageism. The most common one, experienced by nearly 80%, was agreeing with the statement that "having health problems is part of getting older" -- even though 83% of the people surveyed described their own health as good or very good. This kind of "internalized" ageism also included agreeing with the statements that feeling lonely, or feeling depressed, sad or worried, are part of getting older.

Meanwhile, 65% of the older adults said they regularly see, hear or read jokes about older people, or messages that older adults are unattractive or undesirable.

Another class of ageist experiences -- which the researchers call interpersonal ageism -- was reported as a regular occurrence by 45% of the respondents. These included experiences involving another person, where the older person felt it was assumed that they were having trouble with using technology, seeing, hearing, understanding, remembering, or doing something independently -- or that they don't do anything valuable.

The researchers calculated Everyday Ageism scores for every one of the more than 2,000 poll respondents, based on their responses to all the poll questions.

The overall average score was just over 10. As a group, people who were ages 65 to 80 scored over 11, indicating more ageism experiences those among those ages 50-64.

People who had lower levels of income or education, and those who lived in rural areas, also had average ageism scores that were higher than others. Older adults who reported spending four hours or more every day watching television, browsing the internet or reading magazines had higher scores than those with less exposure to such media.

The researchers then looked at each person's individual score in light of what they had said about their own health, including self-rated physical and mental health, number of chronic health conditions and report of depression symptoms.

They found a close link between higher scores and all four health-related measures. That is, those who reported higher Everyday Ageism scores were more likely to have reported that their overall physical health or overall mental health were fair or poor, more chronic health conditions, and depression symptoms.

A lot of this linkage had to do with internalized ageism measures -- the questions that measured how strongly a person agreed with the statements about health problems, loneliness and sadness being part of getting older. But experiences with the interpersonal forms of ageism were also linked to health-related measues, as were some aspects of ageist messages.

The relationship between ageism experiences in older adults' day-to-day lives and health especially interested poll director and senior author Preeti Malani, M.D., a professor at Michigan Medicine with a background in caring for older adults.

"The fact that our poll respondents who said they'd felt the most forms of ageism were also more likely to say their physical or mental health was fair or poor, or to have a chronic condition such as diabetes or heart disease, is something that needs more examination," she says.

https://www.sciencedaily.com/releases/2022/06/220615113231.htm

Too much self-confidence can endanger health

Especially older people often overestimate their health

May 31, 2022

Science Daily/University of Vienna

Older people who overestimate their health go to the doctor less often. This can have serious consequences for their health, for example, when illnesses are detected too late. By contrast, people who think they are sicker than they actually are visit the doctor more often. This is what a new study by Sonja Spitzer from the Institute for Demography at the University of Vienna and Mujaheed Shaikh from the Hertie School in Berlin found based on data from over 80,000 Europeans aged 50 and older. The results were published in The Journal of the Economics of Aging.

Our confidence affects our behaviour. People who overestimate their abilities earn more, invest their money differently, and are more likely to be leaders. But they also act riskier, have more accidents, and live less healthy by drinking more alcohol, eating less healthily, and sleeping too little.

How people perceive the state of their health can also have consequences for their own health decisions -- like whether to visit a doctor or not. A new study by Sonja Spitzer of the University of Vienna and Hertie School Professor Mujaheed Shaikh finds that individuals who overestimate their health visit the doctor 17.0% less often than those who correctly assess their health, which is crucial for preventive care such as screenings. Similar results were found for dentist visits.

The perception of one's own health has, however, no effect on the number and duration of hospital stays; presumably because hospital stays are more regulated and often require a doctor's referral.

Those who think they are sicker than they are visit the doctor more often

The authors also found that individuals who underestimate their health visit the doctor 21% more frequently. On the one hand, there is the disadvantage that these additional visits could cause unnecessary costs, which is relevant given population ageing and the associated high public health expenditure. On the other hand, people who underestimate their health and therefore pay close attention to it may be particularly fit in the long term, which could have a positive impact on society. Overall, it is difficult for outsiders to assess which visits are justified and which are not.

For their study, the researchers analysed data from over 80,000 Europeans aged 50 and older, using statistical methods. The data were collected as part of the SHARE study (Survey of Health, Aging and Retirement in Europe) between 2006 and 2013. First, the participants were asked how they assessed their health, for example, whether they had problems getting up from a chair after sitting for a long period. Then, the participants had to actually get up from a chair during a test -- this way it can be determined whether someone overestimates, underestimates, or correctly assesses their health. The researchers also took misjudgments related to memory and mobility into account. Overall, the majority of survey participants correctly assess their health (79%), 11% overestimate, and 10% underestimate themselves.

Who knows about their health?

With their new study, the researchers built on a previous study that showed that the perception of health differs greatly depending on age, nationality, and education. The older people are, the more often they overestimate their health. The researchers also found large regional differences: according to the analysis, people in Southern Europe tend to overestimate their health, while people in Central and Eastern Europe often underestimate their health. Educated people are also more likely to correctly assess their health. The scientists' appeal: Focus more on health education and health literacy. How healthy we feel can influence how healthy we actually are in the long term.

https://www.sciencedaily.com/releases/2022/05/220531091527.htm

Childhood circumstances and personality traits are associated with loneliness in older age

May 18, 2022

Science Daily/PLOS

Life circumstances during childhood -- including having fewer friends and siblings, low-quality relationships with parents, bad health and growing up in a poorer household -- are all correlated with a higher rate of loneliness in older age, according to a new study published this week in the open-access journal PLOS ONE by Sophie Guthmuller of Vienna University of Economics and Business, Austria.

Loneliness has been a growing topic of interest over the last decade, as it has been shown to be linked with ill health and to increase with age. Loneliness is correlated with a higher risk of developing mental conditions, a deterioration in physical health, and is linked to mortality and higher health care utilization.

In the new study, Guthmuller used data from the large cross-national Survey on Health, Ageing, and Retirement in Europe (SHARE), which collects information from individuals across Europe aged 50 and older on health, socioeconomic status, and social and family networks. Loneliness was measured with the R-UCLA Loneliness Scale.

Guthmuller found that, while ill health is the main factor correlated with loneliness in older age, explaining 43.32% of the variance in loneliness, social support in older age also accounts for 27.05% of the variance, personality traits account for 10.42% and life circumstances during childhood account for 7.50%. The odds of loneliness age 50 and over were 1.24 times higher for people who rarely or never had comfortable friends in childhood compared to those who more often had friends, 1.34 times higher in those who had a fair or poor relationship with their mother as a child compared to those with an excellent maternal relationship, and 1.21 times higher when one grew up in a household with poor wealth compared to those in a wealthy household. Loneliness was more common in individuals with a neurotic personality (OR 1.20) and less common in those who scored highly for conscientiousness, extraversion, agreeableness and openness.

Guthmuller points out that the findings of this study confirm the importance of social networks and support in older age, as well as the role of personality traits, and childhood circumstances. She concludes that early interventions are key to targeting later loneliness and that interventions aimed at increasing social support in later life need to be adapted to all personality types.

The author adds: "The study finds, as expected, that health status and social support at older ages are the two main factors correlated with loneliness at age 50+. Interestingly, the study reveals that personality traits and life circumstances during childhood are significantly associated with loneliness later in life, after controlling for a large set of later life conditions. In light of the trend of increasing childhood loneliness, and the impact of the COVID-19 pandemic on children's life, the findings of this study confirms the importance of early life interventions to tackle long term effect on loneliness."

https://www.sciencedaily.com/releases/2022/05/220518140714.htm

Poor eyesight unfairly mistaken for brain decline

May 9, 2022

Science Daily/University of South Australia

Millions of older people with poor vision are at risk of being misdiagnosed with mild cognitive impairments, according to a new study by the University of South Australia.

Cognitive tests that rely on vision-dependent tasks could be skewing results in up to a quarter of people aged over 50 who have undiagnosed visual problems such as cataracts or age-related macular degeneration (AMD).

Age-related macular degeneration is a leading cause of vision loss for older people. It doesn't cause complete vision loss, but severely impacts people's ability to read, drive, cook, and even recognise faces. It has no bearing on cognition.

UniSA researchers recruited 24 participants with normal vision to complete two cognitive tests -- one involving vision-dependent reactive tasks and the other based on verbal fluency.

Using a set of goggles to simulate AMD, the participants scored far lower on the cognitive test involving reaction time tasks than without the goggles. There was no statistical difference with verbal fluency tests when using the goggles.

The study has been published in Scientific Reports.

UniSA PhD candidate Anne Macnamara, who led the study, says the results are a stark reminder that visual impairments -- which affect approximately 200 million people worldwide over the age of 50 -- unfairly affect cognitive scores when tests involve visual abilities.

"A mistaken score in cognitive tests could have devastating ramifications, leading to unnecessary changes to a person's living, working, financial or social circumstances," Macnamara says.

"For example, if a mistaken score contributed to a diagnosis of mild cognitive impairment, it could trigger psychological problems including depression and anxiety.

"People with AMD are already experiencing multiple issues due to vision loss and an inaccurate cognitive assessment is an additional burden they don't need."

Visual impairments are often overlooked in research and clinical settings, the UniSA researchers say, with reduced vision underestimated in up to 50 per cent of older adults.

And with this figure expected to increase in line with an ageing population, it is critical that neuro-degenerative researchers control for vision when assessing people's cognition.

"Mobile apps can now be used to overlay simulated visual impairments onto test materials when piloting their stimuli," Macnamara says.

"Also, researchers can incorporate quick and simple screening tasks before getting people to do cognitive tests. Verbal tasks should always be part of the assessment, too."

https://www.sciencedaily.com/releases/2022/05/220509204939.htmMay 9, 2022

Science Daily/University of South Australia

Millions of older people with poor vision are at risk of being misdiagnosed with mild cognitive impairments, according to a new study by the University of South Australia.

Cognitive tests that rely on vision-dependent tasks could be skewing results in up to a quarter of people aged over 50 who have undiagnosed visual problems such as cataracts or age-related macular degeneration (AMD).

Age-related macular degeneration is a leading cause of vision loss for older people. It doesn't cause complete vision loss, but severely impacts people's ability to read, drive, cook, and even recognise faces. It has no bearing on cognition.

UniSA researchers recruited 24 participants with normal vision to complete two cognitive tests -- one involving vision-dependent reactive tasks and the other based on verbal fluency.

Using a set of goggles to simulate AMD, the participants scored far lower on the cognitive test involving reaction time tasks than without the goggles. There was no statistical difference with verbal fluency tests when using the goggles.

The study has been published in Scientific Reports.

UniSA PhD candidate Anne Macnamara, who led the study, says the results are a stark reminder that visual impairments -- which affect approximately 200 million people worldwide over the age of 50 -- unfairly affect cognitive scores when tests involve visual abilities.

"A mistaken score in cognitive tests could have devastating ramifications, leading to unnecessary changes to a person's living, working, financial or social circumstances," Macnamara says.

"For example, if a mistaken score contributed to a diagnosis of mild cognitive impairment, it could trigger psychological problems including depression and anxiety.

"People with AMD are already experiencing multiple issues due to vision loss and an inaccurate cognitive assessment is an additional burden they don't need."

Visual impairments are often overlooked in research and clinical settings, the UniSA researchers say, with reduced vision underestimated in up to 50 per cent of older adults.

And with this figure expected to increase in line with an ageing population, it is critical that neuro-degenerative researchers control for vision when assessing people's cognition.

"Mobile apps can now be used to overlay simulated visual impairments onto test materials when piloting their stimuli," Macnamara says.

"Also, researchers can incorporate quick and simple screening tasks before getting people to do cognitive tests. Verbal tasks should always be part of the assessment, too."

https://www.sciencedaily.com/releases/2022/05/220509204939.htm

Seven hours of sleep is optimal in middle and old age

April 28, 2022

Science Daily/University of Cambridge

Seven hours is the ideal amount of sleep for people in their middle age and upwards, with too little or too much little sleep associated with poorer cognitive performance and mental health, say researchers from the University of Cambridge and Fudan University.

Sleep plays an important role in enabling cognitive function and maintaining good psychological health. It also helps keep the brain healthy by removing waste products. As we get older, we often see alterations in our sleep patterns, including difficulty falling asleep and staying asleep, and decreased quantity and quality of sleep. It is thought that these sleep disturbances may contribute to cognitive decline and psychiatric disorders in the aging population.

In research published today in Nature Aging, scientists from the UK and China examined data from nearly 500,000 adults aged 38-73 years from the UK Biobank. Participants were asked about their sleeping patterns, mental health and wellbeing, and took part in a series of cognitive tests. Brain imaging and genetic data were available for almost 40,000 of the study participants.

By analysing these data, the team found that both insufficient and excessive sleep duration were associated with impaired cognitive performance, such as processing speed, visual attention, memory and problem-solving skills. Seven hours of sleep per night was the optimal amount of sleep for cognitive performance, but also for good mental health, with people experiencing more symptoms of anxiety and depression and worse overall wellbeing if they reported sleeping for longer or shorter durations.

The researchers say one possible reason for the association between insufficient sleep and cognitive decline may be due to the disruption of slow-wave -- 'deep' -- sleep. Disruption to this type of sleep has been shown to have a close link with memory consolidation as well as the build-up of amyloid -- a key protein which, when it misfolds, can cause 'tangles' in the brain characteristic of some forms of dementia. Additionally, lack of sleep may hamper the brain's ability to rid itself of toxins.

The team also found a link between the amount of sleep and differences in the structure of brain regions involved in cognitive processing and memory, again with greater changes associated with greater than or less than seven hours of sleep.

Having a consistent seven hours' sleep each night, without too much fluctuation in duration, was also important to cognitive performance and good mental health and wellbeing. Previous studies have also shown that interrupted sleep patterns are associated with increased inflammation, indicating a susceptibility to age-related diseases in older people.

Professor Jianfeng Feng from Fudan University in China said: "While we can't say conclusively that too little or too much sleep causes cognitive problems, our analysis looking at individuals over a longer period of time appears to support this idea. But the reasons why older people have poorer sleep appear to be complex, influenced by a combination of our genetic makeup and the structure of our brains."

The researchers say the findings suggest that insufficient or excessive sleep duration may be a risk factor for cognitive decline in ageing. This is supported by previous studies that have reported a link between sleep duration and the risk of developing Alzheimer's disease and dementia, in which cognitive decline is a hallmark symptom.

Professor Barbara Sahakian from the Department of Psychiatry at the University of Cambridge, one of the study's authors, said: "Getting a good night's sleep is important at all stages of life, but particularly as we age. Finding ways to improve sleep for older people could be crucial to helping them maintain good mental health and wellbeing and avoiding cognitive decline, particularly for patients with psychiatric disorders and dementias."

https://www.sciencedaily.com/releases/2022/04/220428125425.htm

Calming overexcited neurons may protect brain after stroke

New data prompts reconsideration of decades-old theory about brain injury due to stroke

April 21, 2022

Science Daily/Washington University School of Medicine

A new study has prompted scientists to reconsider a once-popular yet controversial idea in stroke research.

Neuroscientists believed that, in the aftermath of a stroke, calming overexcited neurons might prevent them from releasing a toxic molecule that can kill neurons already damaged by lack of oxygen. This idea was supported by studies in cells and animals, but it lost favor in the early 2000s after numerous clinical trials failed to improve outcomes for stroke patients.

But a fresh approach has yielded evidence that the idea may have been discarded too hastily. The new findings are available online in the journal Brain.

By scanning the whole genomes of nearly 6,000 people who had experienced strokes, researchers at Washington University School of Medicine in St. Louis identified two genes associated with recovery within the pivotal first 24 hours after stroke. Events -- good or bad -- that occur in the first day set stroke patients on their courses toward long-term recovery. Both genes turned out to be involved in regulating neuronal excitability, providing evidence that overstimulated neurons influence stroke outcomes.

"There's been this lingering question about whether excitotoxicity really matters for stroke recovery in people," said co-senior author Jin-Moo Lee, MD, PhD, the Andrew B. and Gretchen P. Jones Professor and head of the Department of Neurology. "We can cure stroke in a mouse using blockers of excitotoxicity. But in humans we performed numerous clinical trials, and we couldn't move the needle. Every last one of them was negative. In this study, out of 20,000 genes, the top two genetic hits point to mechanisms involving neuronal excitation. That's pretty remarkable. This is the first genetic evidence that shows excitotoxicity matters in people and not just in mice."

Every year nearly 800,000 people in the U.S. have ischemic strokes, the most common kind of stroke. Ischemic strokes occur when a clot blocks a blood vessel and cuts off oxygen to part of the brain, triggering sudden numbness, weakness, confusion, difficulty speaking or other symptoms. Over the next 24 hours, some people's symptoms continue to worsen while others' stabilize or improve.

In the 1990s, Dennis Choi, MD, PhD, then head of the Department of Neurology at Washington University, performed groundbreaking research on excitotoxicity in stroke. He and others showed that stroke can cause neurons to release large amounts of glutamate, a molecule that transmits excitatory messages between neurons. Glutamate is constantly being released by neurons as part of the normal functioning of the nervous system, but too much all at once can be toxic. Efforts to translate this basic research into therapies for people did not pan out, and eventually pharmaceutical companies let their anti-excitotoxic drug development programs lapse.

But Lee, who formerly worked on excitotoxicity with Choi, did not give up. He teamed up with genetics researcher and co-senior author Carlos Cruchaga, PhD, the Barbara Burton and Reuben M. Morriss III Professor of Neurology and a professor of psychiatry; first author Laura Ibañez, PhD, an assistant professor of psychiatry; and co-author Laura Heitsch, MD, an assistant professor of emergency medicine and of neurology, to tackle the question of what drives post-stroke brain injury. The team identified people who had experienced strokes, and they looked for genetic differences between those who naturally recovered substantial function in the first day and those who did not.

As members of the International Stroke Genetics Consortium, the research team was able to study 5,876 ischemic stroke patients from seven countries: Spain, Finland, Poland, the United States, Costa Rica, Mexico and South Korea. They measured each person's recovery or deterioration over the first day using the difference between their scores on the National Institutes of Health (NIH) Stroke Scale at six and 24 hours after symptoms first appeared. The scale gauges a person's degree of neurological impairment based on measures such as the ability to answer basic questions such as "How old are you?"; to perform movements such as holding up the arm or leg; and to feel sensation when touched.

The researchers performed a genomewide association study by scanning the participants' DNA for genetic variations related to the change in their NIH stroke scale scores. The top two hits were genes that coded for the proteins ADAM23 and GluR1. Both are related to sending excitatory messages between neurons. ADAM23 forms bridges between two neurons so that signaling molecules such as glutamate can be passed from one to the other. GluR1 is a receptor for glutamate.

"We started with no hypotheses about the mechanism of neuronal injury," Cruchaga said. "We started with the assumption that some genetic variants are associated with stroke recovery, but which ones they are, we did not guess. We tested every single gene and genetic region. So the fact that an unbiased analysis yielded two genes involved in excitotoxicity tells us that it must be important."

In the years since anti-excitotoxic drug development was abandoned, clot-busting drugs have become the standard of care for ischemic stroke. Such drugs aim to restore blood flow so that oxygen -- and anything else in the bloodstream, including medication -- can reach affected brain tissue. Consequently, experimental neuroprotective therapies that failed in the past might be more effective now that they have a better chance of reaching the affected area.

"We know that that first 24-hour period has the greatest impact on outcomes," Lee said. "Beyond 24 hours, there's diminishing returns in terms of influence on long-term recovery. Right now, we don't have any neuroprotective agents for that first 24 hours. Many of the original studies with anti-excitotoxic agents were performed at a time when we weren't sure about the best trial design. We've learned a lot about stroke in the last few decades. I think it's time for a re-examination."

https://www.sciencedaily.com/releases/2022/04/220421181207.htm

Risky driving behaviors increase as common sleep disorder worsens

Diagnosing, treating sleep apnea may make driving safer for older adults

April 20, 2022

Science Daily/Washington University School of Medicine

People with sleep apnea wake up tired in the morning, no matter how many hours they actually sleep. The condition causes them to briefly stop and restart breathing dozens or even hundreds of times a night. Even though such breathing interruptions often don't awaken those with apnea, they prevent them from sinking into deep, refreshing sleep.

A new study puts a number on how dangerous such chronic tiredness can be, at least in regard to driving. For every eight additional breathing interruptions per hour, the odds of making a dangerous driving move such as speeding, braking hard or accelerating suddenly increase by 27%, according to a study by researchers at Washington University School of Medicine in St. Louis.

Older adults are more likely to develop sleep apnea. They also are more likely to be seriously injured or killed in a car accident. The findings, available online in the journal Sleep, suggest that screening older adults for sleep apnea and for treatment, if needed, may help older people continue driving safely for longer.

"The percentage of older adults with mild sleep apnea is 30% to 50%, but if such adults don't have daytime sleepiness or other evidence of impairment, they may not come to medical attention," said co-senior author Brendan Lucey, MD, an associate professor of neurology and director of Washington University's Sleep Medicine Center. "However, these findings suggest that we might want a lower threshold to evaluate older adults for sleep apnea and track their breathing interruptions. If their conditions worsen by just eight interruptions an hour, that could have significant adverse effects on their driving and their risk of suffering serious injury."

People 65 and over are the most responsible drivers on the road. They obey speed limits. They drive defensively. They avoid driving at night, in bad weather and in unfamiliar places. But the changes that often come with advancing age -- such as deteriorating vision, slower reflexes and, yes, difficulty sleeping -- can undermine even the safest habits.

Lucey teamed up with driving researcher Ganesh M. Babulal, PhD, OTD, an assistant professor of neurology and the paper's co-senior author, to investigate the relationship between sleep apnea and risky driving behaviors. Participants were recruited from ongoing studies at Washington University's Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight ADRC).

Babulal and Lucey monitored the driving and sleep habits of 96 older adults under real-world conditions. They used a commercially available take-home test to identify people with sleep apnea and measure its severity. Less than five breathing interruptions per hour is considered normal, five to 15 is mild sleep apnea, 15 to 30 is moderate, and greater than 30 is severe.

To assess driving habits, the researchers installed a chip developed by Babulal and colleagues into participants' personal vehicles and monitored their driving for a year, focusing on episodes of hard braking, sudden acceleration and speeding. In total, they collected data on more than 100,000 trips. Participants also were evaluated by researchers at the Knight ADRC for cognitive impairments and molecular signs of early Alzheimer's disease.

Even though all participants were cognitively normal, about a third had brain changes indicative of early Alzheimer's disease. The researchers found that the frequency with which drivers made dangerous moves behind the wheel rose in parallel with the frequency with which their sleep was interrupted at night, regardless of whether their brains bore the marks of early Alzheimer's.

"We didn't have cameras in the vehicles, so we don't know exactly what happened that caused someone to, say, brake hard suddenly," Babulal said. "But it could be something like a stoplight that they didn't realize was red until they got close and had to stomp on the brakes. The more tired you are, the less attention you have to deploy to the task at hand, especially if it is novel and constantly changing."

The study helps untangle the ways aging-associated risk factors such as poor sleep and Alzheimer's disease put older adults in danger while driving, and could aid efforts to find ways to maximize years of safe driving, the researchers said.

"Driving always carries the risk of crashing, and older adults are at risk of more severe injury than younger adults if they experience a crash," Babulal said. "But we can't just tell them to give up their keys. When older people stop driving, they lose a lot of their independence and mobility, which is often associated with negative health and social outcomes. What we want to understand is what puts them at a higher risk so we can intervene and help them stay behind the wheel, safely, for as long as possible."

https://www.sciencedaily.com/releases/2022/04/220420170509.htm

Most older adults want to 'age in place' but many haven't taken steps to help them do so

From home safety and accessibility, to social support, community services and paid in-home help, National Poll on Healthy Aging shows varied preparation

April 13, 2022

Science Daily/University of Michigan

The vast majority of people over 50 say it's important that they keep living in their current homes for as long as possible. But a new poll shows many of them haven't planned or prepared for "aging in place," and a sizable percentage might have a hard time paying for in-home help.

The pandemic's toll on older adults, especially those in nursing homes and other long-term care facilities, has brought the issue of living independently at home into the national spotlight. So have policy proposals around changing the ability of Medicare and Medicaid to pay for virtual care and in-home help.

But the new findings from the National Poll on Healthy Aging suggest many people in their 50s, 60s and 70s need to do more to modify their homes or plan for services they may need if they want to avoid or delay needing to move. The poll also shows differences in aging-in-place readiness among the 28% of older adults who told the poll that they live alone.

The poll is based at U-M's Institute for Healthcare Policy and Innovation and supported by AARP and Michigan Medicine, the University of Michigan's academic medical center.

In all, 88% of people between the ages of 50 and 80 said it was very or somewhat important to them that they live in their homes as long as possible. But only 15% said they've given a lot of consideration to how their home may need to be modified as they age, while 47% have given it little or no thought.

Meanwhile, 48% of those who live alone said they don't have someone in their lives who could help them with personal care such as bathing and dressing if needed, compared with 27% of those who live with others.

As for hiring help, 19% of older adults are very confident they could afford to pay someone to help with household chores, grocery shopping, personal care or managing their finances. On the other hand, nearly two-thirds of those who called their current physical or mental health status fair or poor said they were not confident or not very confident that they could afford to pay for such help.

"The pandemic's impact on older adults, and policy proposals about home-based services at the federal and state level, mean this is a topic of immediate importance," said Sheria Robinson-Lane, assistant professor at the U-M School of Nursing and IHPI member who worked with the poll team on the report. "Especially for those without as much social support, or with more health needs, it's important to take a proactive approach and plan for the future now."

Poll director Preeti Malani, U-M Medical School infectious disease professor also trained in geriatrics, said that older adults should explore with their health care providers and local social service agencies the kinds of support available to them, and talk with loved ones about their goals.

"Taking steps to understand what's available in the community, through the national Eldercare Locator, the Area Agency on Aging that serves your region, nonprofit organizations and other sources could help older adults be more prepared," she said.

"Family members can help encourage older adults to find out what's available, to invest in home improvements, and to aid them in installing safety devices and technologies that can help keep them aging in place. Think of it as a positive investment toward current safety and future independence -- that can help older adults get past the temptation to put it off for another day."

More findings

The poll finds that 1 in 5 older adults had moved in the past five years. About half of those who moved said they had moved to a home that was easier to get around, while half also said their new home was smaller.

Wherever they live now, 34% said their home definitely has the necessary features that would let them age in place, and 49% said they had at least one 'smart home' device.

But the poll drilled down to ask about specific features and technologies. While 88% had a main-floor bathroom and 78% had a bedroom on the main floor, which could reduce the need to climb stairs and reduce fall risk, fewer older adults had other features.

For instance, 32% said they had grab bars in the bathroom, and less than 10% had safety-focused technologies such as alarms on their stoves or personal emergency response systems. Only 7% said they had a barrier-free shower, and 9% said that it was difficult to use the main rooms in their home because of clutter or large amounts of possessions there.

"AARP research consistently shows that the majority of older adults want to stay in their homes and communities for as long as possible," said Indira Venkat, vice president of consumer insights at AARP. "Unfortunately, most houses weren't built to support the needs of people across the many stages of life. The best way to continue living in the home you love is to plan ahead and make changes that will accomodate your needs today and in the future."

In late 2021, AARP published a report on the preferences of adults over 18 about their future home and community circumstances, including the ability to age in place.

The poll report is based on findings from a nationally representative survey conducted by NORC at the University of Chicago for IHPI, and administered online and via phone in January and February 2022 among nearly 2,277 older adults ages 50-80. The sample was subsequently weighted to reflect the U.S. population.

Poll: https://www.healthyagingpoll.org/reports-more

https://www.sciencedaily.com/releases/2022/04/220413203139.htm

How to reduce loneliness: Meaningful activities can improve health, well-being

April 6, 2022

Science Daily/Penn State

Free time is sometimes idealized, but research shows free time can sometimes be unhealthy by increasing loneliness. A new Penn State study demonstrated that engaging in meaningful, challenging activities during free time can reduce people's loneliness and increase their positive feelings.

An international team of researchers including John Dattilo -- professor of recreation, park, and tourism management at Penn State -- has been studying how to increase leisure and reduce loneliness during the pandemic among both international college students and older adults.

Across two different studies, the researchers found that people who had meaningful, challenging experiences were less lonely -- even when higher levels of social contact and support were not available.

"There is a well-known saying: 'Time flies when you are having fun,'" said Dattilo. "The unspoken corollary is that time drags when you are bored. Our research shows that both of these ideas are true. By engaging in meaningful activities during free time that demand focus, people can reduce loneliness and increase momentary happiness."

Loneliness and the pandemic

Despite -- or perhaps in part because of -- technology that can connect people anywhere at any time, previous research has shown that loneliness has increased over recent decades.

Loneliness touches people of all ages, from children to young adults to older adults. The COVID-19 pandemic, which caused many people to alter their social behavior to prevent the spread of disease, exacerbated the problem of loneliness around the world.

"Loneliness is very connected to our health," Dattilo explained. "Psychological, emotional, and cognitive health are all challenged when people are lonely. Loneliness is associated with depression and other mental health challenges."

"Troublingly," continued Dattilo, "there is a loneliness epidemic. And while the COVID-19 pandemic has increased loneliness for many people, the silver lining is that the pandemic has also exposed the scope of the loneliness problem. Anything we can do as a society to reduce loneliness should improve health and happiness for people everywhere."

In a new article that appears in Leisure Sciences, the researchers explored loneliness among international university students in Taiwan. The same research team also published an article about reducing loneliness among nursing home residents late in 2021.

Prior research has shown that loneliness among international university students is common around the world. International students are removed from their social networks and live in a different culture, often one that speaks a different language. Typically, international students can prevent loneliness by participating in social activities to receive 'social support,' the sense that they are cared for by the people with whom they socialize. During the pandemic, however, many group-based activities and social gatherings have been cancelled or prohibited.

Additionally, the researchers identified that the online social opportunities that became available in the pandemic may be less accessible to international students because of language and cultural differences.

Flow reduces loneliness 

According to the researchers, reduced loneliness is associated with engaging in enjoyable activities that require both concentration and skill.

"When people become engrossed in what they are doing, they enter a state that is called 'flow,'" Dattilo explained. "Flow can be achieved by engaging in mental or physical activities that we value and that require us to concentrate fully to use our skills."

For people to achieve a state of flow, an activity must require a good deal of their skill but not be so difficult that it seems impossible. Additionally, it must demand concentration to execute and be meaningful to the participant. Artistic endeavors like playing the piano or painting can induce flow. So can physical activities like skiing or chopping wood, along with mental tasks like writing or storytelling. What induces flow differs from person to person based on individual skills and values.

"When we enter a state of flow, we become absorbed and focused, and we experience momentary enjoyment," Dattilo continued. "When we leave a state of flow, we are often surprised by how much time has passed."

People with extensive free time -- like college students who are locked down during a pandemic, or people who live in a nursing home -- can achieve flow when they engage in activities they find to be meaningful. In this way, time passes quickly for them, their life has meaning, and their experience of loneliness is reduced, according to the researchers.

Social support from friends and acquaintances is a primary way that people reduce loneliness. For many people, however, obtaining adequate social support can be challenging. Though the researchers found that students with high levels of social support were less lonely, they found that flow was even more important to reducing loneliness. Helping people achieve flow can reduce loneliness in situations where social support is insufficient. More importantly, it can reduce loneliness for people in any situation.

Encouraging flow for everyone 

Some activities never induce flow, while other activities may or may not, depending on the individual. According to Dattilo, there is nothing wrong with watching television, but, typically, it does not help people enter a state of flow because they are unlikely to experience any challenges. Additionally, different people find different activities meaningful and enjoyable. Nursing home residents are unlikely to enjoy playing bingo if they did not enjoy similar games when they were younger, said Dattilo.

"Learning which activities might enable someone to enter a state of flow requires asking questions and listening," said Dattilo. "People tend to thrive on healthy engagement and challenge. My collaborators and I hope that this research will help people live fuller, happier, healthier lives."

https://www.sciencedaily.com/releases/2022/04/220406132430.htm

The secret to staying young: New research highlights power of life long exercise to keep muscles healthy

March 21, 2022

Science Daily/The Physiological Society

Lifelong physical activity could protect against age-related loss of muscle mass and function, according to research published in The Journal of Physiology. Individuals aged 68 and above who were physically active throughout their life have healthier ageing muscle that has superior function and is more resistant to fatigue compared to inactive individuals, both young and old.

This is the first study to investigate muscle, stem cell and nerve activity in humans. The researchers from University of Copenhagen, Denmark, found that elderly individuals who keep physically active throughout their adult life, whether by taking part in resistance exercise, ball games, racket sports, swimming, cycling, running and/or rowing had a greater number of muscle stem cells, otherwise known as satellite cells in their muscle. These cells are important for muscle regeneration and long-term growth and protect against nerve decay.

46 male participants took part in the study. They were divided into three groups: young sedentary (15), elderly lifelong exercise (16) and elderly sedentary (15). They performed a heavy resistance exercise, sitting in a mechanical chair performing a knee extension movement to evaluate muscle function. The amount of force produced was measured. Blood samples were taken, and muscle biopsies were analysed from both legs. The researchers found elderly lifelong exercisers outperformed both the elderly and young sedentary adults.

Lead author, Casper Soendenbroe, University of Copenhagen, Denmark said:

"This is the first study in humans to find that lifelong exercise at a recreational level could delay some detrimental effects of ageing. Using muscle tissue biopsies, we've found positive effects of exercise on the general ageing population. This has been missing from the literature as previous studies have mostly focused on master athletes, which is a minority group. Our study is more representative of the general population aged 60 and above, as the average person is more likely to take part in a mixture of activities at a moderate level. That's why we wanted to explore the relation between satellite cell content and muscle health in recreationally active individuals. We can now use this as a biomarker to further investigate the link between exercise, ageing and muscle health."

"The single most important message from this study, is that even a little exercise seems to go a long way, when it comes to protecting against the age-related decline in muscle function. This is an encouraging finding which can hopefully spur more people to engage in an activity that they enjoy. We still have much to learn about the mechanisms and interactions between nerves and muscles and how these change as we age. Our research takes us one step closer."

It is worth noting that the study was only carried out in males and the average age was 73. As the effects of ageing on muscle health become more pronounced at 80+ years, follow up studies are needed to see if the benefits of lifelong exercise are maintained later in life. Further, investigation on recreational activity and muscle health need to be carried out in females.

https://www.sciencedaily.com/releases/2022/03/220321103818.htm

Extended napping in seniors may signal dementia

Daytime sleep duration triples after Alzheimer's diagnosis

March 17, 2022

Science Daily/University of California - San Francisco

Daytime napping among older people is a normal part of aging -- but it may also foreshadow Alzheimer's disease and other dementias. And once dementia or its usual precursor, mild cognitive impairment, are diagnosed, the frequency and/or duration of napping accelerates rapidly, according to a new study.

The study, led by UC San Francisco and Harvard Medical School together with Brigham and Women's Hospital, its teaching affiliate, departs from the theory that daytime napping in older people serves merely to compensate for poor nighttime sleep. Instead, it points to work by other UCSF researchers suggesting that dementia may affect the wake-promoting neurons in key areas of the brain, the researchers state in their paper publishing March 17, 2022, in Alzheimer's and Dementia: The Journal of the Alzheimer's Association.

"We found the association between excessive daytime napping and dementia remained after adjusting for nighttime quantity and quality of sleep," said co-senior author Yue Leng, MD, PhD, of the UCSF Department of Psychiatry and Behavioral Sciences.

"This suggested that the role of daytime napping is important itself and is independent of nighttime sleep," said Leng, who partnered with Kun Hu, PhD, of Harvard Medical School, in senior-authoring the paper.

Watch-Like Devices, Annual Evaluations Used to Measure Naps, Cognition

In the study, the researchers tracked data from 1,401 seniors, who had been followed for up to 14 years by the Rush Memory and Aging Project at the Rush Alzheimer's Disease Center in Chicago. The participants, whose average age was 81 and of whom approximately three-quarters were female, wore a watch-like device that tracked mobility. Each prolonged period of non-activity from 9 a.m. to 7 p.m. was interpreted as a nap.

The device was worn every year continuously for up to 14 days, and once a year each participant underwent a battery of neuropsychological tests to evaluate cognition. At the start of the study 75.7% of participants had no cognitive impairment, while 19.5% had mild cognitive impairment and 4.1% had Alzheimer's disease.

For participants who did not develop cognitive impairment, daily daytime napping increased by an average 11 minutes per year. The rate of increase doubled after a diagnosis of mild cognitive impairment to a total of 24 minutes and nearly tripled to a total of 68 minutes after a diagnosis of Alzheimer's disease.

When the researchers looked at the 24% of participants who had normal cognition at the start of the study but developed Alzheimer's six years later, and compared them with those whose cognition remained stable, they found differences in napping habits. Participants who napped more than an hour a day had a 40% higher risk of developing Alzheimer's than those who napped less than an hour a day; and participants who napped at least once a day had a 40% higher risk of developing Alzheimer's than those who napped less than once a day.

The research confirms the results of a 2019 study, of which Leng was the first author, that found older men who napped two hours a day had higher odds of developing cognitive impairment that those who napped less than 30 minutes a day. The current study builds on these findings by evaluating both daytime napping and cognition each year, hence addressing directionality, Leng notes.

Loss of Wake-Promoting Neurons May Account for Longer Naps 

According to the researchers, increase in napping may be explained by a further 2019 study, by other UCSF researchers, comparing the postmortem brains of people with Alzheimer's disease to those without cognitive impairment. Those with Alzheimer's disease were found to have fewer wake-promoting neurons in three brain regions. These neuronal changes appear to be linked to tau tangles -- a hallmark of Alzheimer's, characterized by increased activity of enzymes causing the protein to misfold and clump.

"It is plausible that our observed associations of excessive daytime napping at baseline, and increased risk for Alzheimer's disease during follow-up, may reflect the effect of Alzheimer's disease pathology at preclinical stages," the authors noted.

The study shows for the first time that napping and Alzheimer's disease "seem to be driving each other's changes in a bi-directional way," said Leng, who is also affiliated with the UCSF Weill Institute for Neurosciences. "I don't think we have enough evidence to draw conclusions about a causal relationship, that it's the napping itself that caused cognitive aging, but excessive daytime napping might be a signal of accelerated aging or cognitive aging process," she said.

"It would be very interesting for future studies to explore whether intervention of naps may help slow down age-related cognitive decline."

https://www.sciencedaily.com/releases/2022/03/220317111848.htm

Physical activity may protect your brain as you age

Even just a few more steps a day benefits cognitive function

March 8, 2022

Science Daily/University of Georgia

We all know we should exercise and eat healthy. But doing that isn't just good for maintaining your figure as you age.

New research from the University of Georgia shows that physical activity could help protect your cognitive abilities as you age. And it doesn't have to be intense exercise to make an impact.

"This finding isn't saying, 'If you're older, you need to go out there and start running marathons,'" said Marissa Gogniat, lead author of the study and a recent doctoral graduate in psychology from the Franklin College of Arts and Sciences. "This is saying if you get more steps, if you're moving around your environment a little bit more, that can be helpful to your brain health and keep you more independent as you age."

Exercise improves brain function 

Published in Sport Sciences for Health, the study followed 51 older adults, tracking their physical activity and fitness measurements. The participants performed tests specifically designed to measure cognitive functioning and underwent MRIs to assess brain functioning.

They also wore a device that measured the intensity of the wearer's physical activity, number of steps taken and distance covered. The researchers assessed fitness through a six-minute walking test, during which participants walked as quickly as they could to cover the most distance possible within the time limit.

"We've always been told it's good to exercise, but I think this is some evidence that exercise can actually change your brain," Gogniat said. "And that impacts the way you're able to function in your daily life."

Brain networks improve with physical activity

The brain is made up of a bunch of distinct networks. Those networks are in constant communication, sending information to each other.

But different parts of the brain are active at different times. The network that is active when the body is at rest, for example, flips off when a person starts trying to complete a task. At that time, another network kicks on.

While one of these networks is active, the other should be shut off. If it's not, that's a sign that a person's brain isn't functioning as well as it should be.

These networks are the key to being able to perform basic tasks in daily life, such as remembering important information and exhibiting self-control. But as people age, these tasks often become more difficult.

This study was the first to examine how these networks interact with physical activity and fitness to impact how the brain functions.

"This paper is exciting because it gives us some evidence that when people whose brain networks aren't functioning optimally engage in physical activity, we see improvement in their executive function and their independence," Gogniat said. "We're not saying you need to radically change your life.

"Maybe just take the stairs on the way to work. Stand up and walk around a little bit more. That's where you get the most bang for your buck, not crazy, high-intensity exercise."

https://www.sciencedaily.com/releases/2022/03/220308155637.htm

Lifetime of knowledge can clutter memories of older adults

February 11, 2022

Science Daily/Cell Press

When a person tries to access a memory, their brain quickly sifts through everything stored in it to find the relevant information. But as we age, many of us have difficulty retrieving memories. In a review publishing in the journal Trends in Cognitive Sciences on February 11, researchers propose an explanation for why this might be happening: the brains of older adults allocate more space to accumulated knowledge and have more material to navigate when attempting to access memories. While this wealth of prior knowledge can make memory retrieval challenging, the researchers say it has its upsides -- this life experience can aid with creativity and decision-making.

Researchers Tarek Amer (@tarekamerphd) of Columbia University and Harvard University, Jordana Wynn (@jordwynn) of Harvard University, and Lynn Hasher of the University of Toronto looked at several behavioral and neuroimaging studies, which show that older adults have difficulty suppressing information that is no longer relevant and that when searching for a specific memory, they often retrieve other, irrelevant memories along with it. The studies also showed that when given a cognitive task, older adults rely more heavily on previous knowledge than younger adults do.

While the researchers focus primarily on the difficulties that these cluttered memories may pose, they also highlight a few situations in which these crowded memoryscapes may be useful. "Evidence suggests that older adults show preserved, and at times enhanced, creativity as a function of enriched memories," the researchers write. They further hypothesize that older adults may be well served by their prior knowledge when it comes to decision-making, where they can pull on their accumulated wisdom.

With continued study and increased understanding of how memory works in older adults, researchers are hopeful that they may be able to find new ways to help them. They write, "It is possible that the increased binding and richer encodings of older adults can even be leveraged to improve older adults' learning and memory."

https://www.sciencedaily.com/releases/2022/02/220211111852.htm

Eating prunes may help protect against bone loss in older women

February 9, 2022

Science Daily/Penn State

It's already well known that prunes are good for your gut, but new Penn State research suggests they may be good for bone health, too.

In a research review, the researchers found that prunes can help prevent or delay bone loss in postmenopausal women, possibly due to their ability to reduce inflammation and oxidative stress, both of which contribute to bone loss.

"In postmenopausal women, lower levels of estrogen can trigger a rise of oxidative stress and inflammation, increasing the risk of weakening bones that may lead to fractures," said Connie Rogers, associate professor of nutritional sciences and physiology. "Incorporating prunes into the diet may help protect bones by slowing or reversing this process."

The review was recently published in the journal Advances in Nutrition.

Osteoporosis is a condition in which bones become weak or brittle that can happen to anyone at any age, but according to the researchers is most common among women over the age of 50. The condition affects more than 200 million women worldwide, causing almost nine million fractures each year.

While medications exist to treat osteoporosis, the researchers said there is a growing interest for ways to treat the condition with nutrition.

"Fruits and vegetables that are rich in bioactive compounds such as phenolic acid, flavonoids and carotenoids can potentially help protect against osteoporosis," said Mary Jane De Souza, professor of kinesiology and physiology, "with prunes in particular gaining attention in previous research."

According to the researchers, bones are maintained throughout adult life by processes that continually build new bone cells while removing old ones. But after the age of 40, this breaking down of old cells begins to outpace the formation of new ones. This can be caused by multiple factors including inflammation and oxidative stress, which is when free radicals and antioxidants are unbalanced in the body.

Prunes, however, have many nutritional benefits such as minerals, vitamin K, phenolic compounds and dietary fiber -- all which may be able to help counter some of these effects.

For their review, the researchers analyzed data from 16 preclinical studies in rodent models, ten preclinical studies and two clinical trials. Across the studies, the researchers found evidence that eating prunes helped reduce inflammation and oxidative stress and promoted bone health.

For example, the clinical trials found that eating 100 grams of prunes -- about 10 prunes -- each day for one year improved bone mineral density of bones in the forearm and lower spine and decreased signs of bone turnover.

Additionally, eating 50 or 100 grams of prunes a day for six months prevented loss of total bone mineral density and decreased TRAP-5b -- a marker of bone resorption -- compared to women who didn't eat prunes.

"Taken together, evidence from in vitro, preclinical studies, and limited clinical studies suggest prunes may help to reduce bone loss," Rogers said. "This may be due to altered bone turnover and by inhibiting inflammation and suppressing markers of oxidative stress."

The researchers said one potential mechanism for the effects is prunes triggering a change in the gut microbiome that then lowers inflammation in the colon. This may then lower levels of pro-inflammatory cytokines and markers of oxidative damage.

In the future, the researchers plan to further report on the effects of prune consumption for 12 months on bone outcomes, inflammatory pathways and the gut microbiota in a randomized controlled trial that was led by De Souza.

Janhavi Damani, graduate student in the Huck Institutes of the Life Sciences; Hannah VanEvery, graduate student in nutritional sciences; and Nicole Strock, postdoctoral scholar in kinesiology, also participated in this work.

The California Dried Plum Board helped support this research.

https://www.sciencedaily.com/releases/2022/02/220209112110.htm

More spice could help seniors avoid salt

February 3, 2022

Science Daily/Washington State University

Add a little spicy seasoning to a low sodium meal, and adults over the age of 60 may have a harder time noticing a lack of salt, according to a new study in the journal Food Quality and Preference.

Led by Carolyn Ross, a professor of Food Sciences at Washington State University, the study tested saltiness perception in older adults using white sauce formulations with varying amounts of salt and different spices and seasonings added.

The results of the analysis showed the addition of chipotle seasoning to the white sauce made it difficult for the study participants to differentiate between the samples with low and high levels of salt. Conversely, the addition of herbs, such as basil leaves, garlic powder and coarse ground pepper, was not as effective at masking the samples with less salt. The research points to the significant role that spice could play in reducing salt intake for people over 60.

"We were working specifically with a population of older adults to see if we could reduce the amount of salt in a product and then tailor it to their tastes," Ross said. "This is important because the ability to taste and smell is known to weaken with age, and weaker perception of salty flavors may induce people to season their food with excessive salt, which may increase their risk of cardiovascular disease."

For their study, Ross and María Laura Montero, a postdoctoral researcher in the WSU School of Food Sciences, recruited 39 healthy people over the age of 60 to participate in an in-person taste testing experiment that took place over several days slightly prior to the onset of the COVID-19 pandemic.

Previous research examining saltiness perception in older adults has tended to use water as a matrix for tasting experiments rather than actual food products. To generate more realistic data in terms of what people actually enjoy eating, Ross and Montero used a white sauce formulation that is commonly found in ready-to-eat Cajun chicken pasta meals.

The study participants were asked to compare three different formulations of the sauce at five different salt concentrations. One of the formulations had no added herbs, the second had just herbs, and the third had both herbs and chipotle seasoning. Their results showed the formulation with both herbs and chipotle seasoning made it difficult for the seniors to determine the amount of salt being used while the formulation with exclusively herbs did not.

In addition to administering the taste test, the researchers surveyed their participants about their oral and olfactory health, the number and type of medications they were taking and any other pre-existing conditions that might affect their saltiness perception.

Their analysis showed there was a positive correlation between poor oral health and the number of medications each participant was taking, which could be a result of less saliva production; however, their data on whether or not this was the main cause of lowered saltiness perception wasn't conclusive.

Moving forward, when it is once again feasible to recruit participants for in-person studies, the researchers plan to follow-up with a larger study evaluating lower salt concentrations as well as different herb and spice concentrations.

"To date, a clear relationship between taste loss, and thus higher taste thresholds, and eating behavior remains to be established," Ross said. "So, we are investigating a bunch of different possible factors."

https://www.sciencedaily.com/releases/2022/02/220203083613.htm

People with less memory loss in old age gain more knowledge

New findings on cognitive development in adulthood

February 3, 2022

Science Daily/Max Planck Institute for Human Development

Do cognitive abilities change together, or do they change independently of each other? An international research team from the USA, Sweden, and Germany involving the Max Planck Institute for Human Development has presented new findings now published in Science Advances.

At the age of 20, people usually find it easier to learn something new than at the age of 70. People aged 70, however, typically know more about the world than those aged 20. In lifespan psychology this is known as the difference between "fluid" and "crystallized" cognitive abilities. Fluid abilities primarily capture individual differences in brain integrity at the time of measurement, whereas crystallized abilities primarily capture individual differences in accumulated knowledge.

Accordingly, fluid and crystallized abilities differ in their average age trajectories. Fluid abilities like memory already start to decline in middle adulthood. In contrast. crystallized abilities such as vocabulary show increases until later adulthood and only evince decline in advanced old age.

This divergence in the average trajectories of fluid and crystallized abilities has led to the assumption that people can compensate for fluid losses with crystallized gains. For instance, if an individual's memory declines, this loss, it is assumed, can be compensated for by an increase in knowledge.

A study of a research team from Germany, Sweden and the USA now shows that this compensation hypothesis has more limits than previously claimed. The researchers analyzed data from two longitudinal studies, the Virginia Cognitive Aging Project (VCAP) study from the USA and the Betula study from Sweden. In the VCAP study, 3633 female and 1933 male participants aged 18-99 years at the first occasion of measurement were followed for a period of up to 18 years and assessed up to eight times. The Betula study involved 1803 women and 1517 men who were between 25 and 95 years old at the first measurement occasion and examined up to four times over 18 years.

The research team used multivariate methods of change measurement to examine the extent to which individual differences in changes in crystallized abilities are related to individual differences in fluid changes. The findings are clear: The correlations between the two types of changes observed in both studies were very high. Thus, individual differences in cognitive development are, to a large extent, domain-general and do not follow the fluid-crystallized divide. What this means is that individuals who show greater losses in fluid abilities simultaneously show smaller gains in crystallized abilities, and persons whose fluid abilities hardly decline show large gains in crystallized abilities.

These findings are in accordance with the everyday observation that some people remain mentally fit in many areas into very old age while others' cognitive functioning declines across the board.

"In intelligence research, people often talk about a general factor or g-factor of intelligence that expresses the commonality of different cognitive abilities," says the lead author of the study, Elliot Tucker-Drob of the Department of Psychology and the Population Research Center at the University of Texas at Austin, USA. "In previous work, we have already demonstrated that not only individual differences in cognitive abilities at a given point in time can be captured by a general factor, but also changes of cognitive abilities. Our new results confirm this finding and demonstrate that changes in crystallized abilities can indeed be subsumed under a general factor of common change."

"Our findings call for a revision of textbook knowledge," adds Ulman Lindenberger, Director of the Center for Lifespan Psychology at the Max Planck Institute for Human Development in Berlin. "If those who show the largest fluid losses also show the smallest crystallized gains, then this places tighter limits on the compensatory power of knowledge than previously believed." For example, people whose memory is declining, also show a low gain in knowledge, even though they are in most need of such gains. Conversely, individuals with small fluid losses and strong crystallized gains are less likely to be in need of relying on compensatory processes to begin with.

Overall, the results underscore the great importance of identifying and supporting modifiable influences that contribute to the general maintenance of cognitive abilities in later adulthood and old age. An example is physical exercise that can prevent cardiovascular diseases and thereby help to maintain cognitive abilities.

https://www.sciencedaily.com/releases/2022/02/220203103001.htm

Late-life exercise shows rejuvenating effects on cellular level

January 21, 2022

Science Daily/University of Arkansas

For people who hate exercising, here comes some more bad news: it may also keep you younger. Not just looking younger, but actually younger, on an epigenetic level. By now, the benefits of exercise have been well established, including increased strength of bones and muscles, improved mobility and endurance, and lower risk of heart disease, diabetes and high blood pressure.

But younger?

A study recently published in Aging Cell, "Late-life exercise mitigates skeletal muscle epigenetic aging," suggests this could be the case. The paper was written by a team of seven researchers across three institutions, including Kevin Murach, an assistant professor in the Department of Health, Human Performance and Recreation at the U of A. Murach's grant from the National Institute of Health funded the study, and he was one of three co-first authors.

Bootcamp for Mice

While the paper is dense with data, reflecting the use of several analytic tools, the experiment that generated the data was relatively straightforward. Lab mice nearing the end of their natural lifespan, at 22 months, were allowed access to a weighted exercise wheel. Generally, mice require no coercion to run and will do so voluntarily. Older mice will run anywhere from six to eight kilometers a day, mostly in spurts, while younger mice may run up to 10-12 kilometers. The weighted wheel ensured they built muscle. While there isn't a direct analogue to most human exercise routines, Murach likened it to "a soldier carrying a heavy backpack many miles."

When the mice were studied after two months of progressive weighted wheel running, it was determined that they were the epigenetic age of mice eight weeks younger than sedentary mice of the same age -- 24 months. Murach noted that while the specific strain of mice and their housing conditions can impact lifespans, "historically, they start dropping off after 24 months at a significant rate." Needless to say, when your lifespan is measured in months, an extra eight weeks -- roughly 10 percent of that lifespan -- is a noteworthy gain.

Methylation, My Dear Watson

The science behind this, while complicated, hinges largely on a biological process known as DNA methylation. A recent New York Times article discussing Murach's work on muscle memory described methylation "as a process in which clusters of atoms, called methyl groups, attach themselves to the outside of genes like minuscule barnacles, making the genes more or less likely to turn on and produce particular proteins."

As the body ages, there tends to be increased DNA methylation, or even hypermethylation, at promoter sites on genes in muscle. "DNA methylation changes in a lifespan tend to happen in a somewhat systematic fashion," Murach explained, "to the point you can look at someone's DNA from a given tissue sample and with a fair degree of accuracy predict their chronological age." Due to this, researchers can use one of a number of "methylation clocks" to determine the age of a DNA sample.

DNA Methylation, Aging and Exercise

While the paper strengthens the case for exercise, there is still much that needs to be learned. Though the connection between methylation and aging is clear, the connection between methylation and muscle function is less clear. Murach is not yet prepared to say that the reversal of methylation with exercise is causative for improved muscle health. "That's not what the study was set up to do," he explained. However, he intends to pursue future studies to determine if "changes in methylation result in altered muscle function."

"If so, what are the consequences of this?" he continued. "Do changes on these very specific methylation sites have an actual phenotype that emerges from that? Is it what's causing aging or is it just associated with it? Is it just something that happens in concert with a variety of other things that are happening during the aging process? So that's what we don't know."

https://www.sciencedaily.com/releases/2022/01/220121124840.htm